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Building deep reinforcement learning (RL) agents that find a good policy with few samples has proven notoriously challenging. To achieve sample efficiency, recent work has explored updating neural networks with large numbers of gradient…

Machine Learning · Computer Science 2025-04-04 Claas A Voelcker , Marcel Hussing , Eric Eaton , Amir-massoud Farahmand , Igor Gilitschenski

Dynamic Treatment Regimes (DTRs) provide a systematic framework for optimizing sequential decision-making in chronic disease management, where therapies must adapt to patients' evolving clinical profiles. Inverse probability weighting (IPW)…

Methodology · Statistics 2026-03-26 Chloe Si , David A. Stephens , Erica E. M. Moodie

In recent years, a variety of tasks have been accomplished by deep reinforcement learning (DRL). However, when applying DRL to tasks in a real-world environment, designing an appropriate reward is difficult. Rewards obtained via actual…

Machine Learning · Computer Science 2023-10-04 Kanata Suzuki , Tetsuya Ogata

We propose a general formulation for continuous treatment recommendation problems in settings with clinical survival data, which we call the Deep Survival Dose Response Function (DeepSDRF). That is, we consider the problem of learning the…

Machine Learning · Statistics 2023-09-27 Jie Zhu , Blanca Gallego

Self-distillation (SD) is the process of retraining a student on a mixture of ground-truth labels and the teacher's own predictions using the same architecture and training data. Although SD has been empirically shown to often improve…

Statistics Theory · Mathematics 2026-02-20 Hien Dang , Pratik Patil , Alessandro Rinaldo

In recommender systems, users always choose the favorite items to rate, which leads to data missing not at random and poses a great challenge for unbiased evaluation and learning of prediction models. Currently, the doubly robust (DR)…

Machine Learning · Computer Science 2023-08-25 Haoxuan Li , Chunyuan Zheng , Peng Wu

We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy…

Machine Learning · Statistics 2018-12-06 Ruidi Chen , Ioannis Paschalidis

Lesion appearance is a crucial clue for medical providers to distinguish referable diabetic retinopathy (rDR) from non-referable DR. Most existing large-scale DR datasets contain only image-level labels rather than pixel-based annotations.…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Wenhui Zhu , Peijie Qiu , Natasha Lepore , Oana M. Dumitrascu , Yalin Wang

Distributionally robust reinforcement learning (DR-RL) has recently gained significant attention as a principled approach that addresses discrepancies between training and testing environments. To balance robustness, conservatism, and…

Machine Learning · Computer Science 2026-04-29 Zhenghao Li , Shengbo Wang , Nian Si

To acquire a new skill, humans learn better and faster if a tutor, based on their current knowledge level, informs them of how much attention they should pay to particular content or practice problems. Similarly, a machine learning model…

Machine Learning · Computer Science 2021-06-18 Xinyi Wang , Hieu Pham , Paul Michel , Antonios Anastasopoulos , Jaime Carbonell , Graham Neubig

Deep neural networks have been shown to achieve state-of-the-art performance in several machine learning tasks. Stochastic Gradient Descent (SGD) is the preferred optimization algorithm for training these networks and asynchronous SGD…

Machine Learning · Computer Science 2016-04-06 Wei Zhang , Suyog Gupta , Xiangru Lian , Ji Liu

Reinforcement learning (RL) has become an effective way to improve prompt alignment and perceptual quality in diffusion and flow-matching generators. A critical step for applying online RL to flow matching is turning the deterministic…

Machine Learning · Computer Science 2026-05-25 Jade Zou , Tao Huang , Weijie Kong , Junzhe Li , Yue Wu , Qi Tian , Jiangfeng Xiong , Jianwei Zhang , Liefeng Bo , Zhao Zhong

Irregularly sampled time series (ISTS) data has irregular temporal intervals between observations and different sampling rates between sequences. ISTS commonly appears in healthcare, economics, and geoscience. Especially in the medical…

Machine Learning · Computer Science 2020-10-27 Chenxi Sun , Shenda Hong , Moxian Song , Hongyan Li

Deep convolutional neural networks (CNNs) have recently achieved great success for single image super-resolution (SISR) task due to their powerful feature representation capabilities. The most recent deep learning based SISR methods focus…

Image and Video Processing · Electrical Eng. & Systems 2020-09-11 Rao Muhammad Umer , Gian Luca Foresti , Christian Micheloni

A dynamic treatment regimen (DTR) is a pre-specified sequence of decision rules which maps baseline or time-varying measurements on an individual to a recommended intervention or set of interventions. Sequential multiple assignment…

Methodology · Statistics 2019-10-23 Brook Luers , Min Qian , Inbal Nahum-Shani , Connie Kasari , Daniel Almirall

Reinforcement learning with verifiable rewards (RLVR) has become a standard paradigm for post-training large language models. While Group Relative Policy Optimization (GRPO) is widely adopted, its coarse credit assignment uniformly…

Machine Learning · Computer Science 2026-04-03 Gengsheng Li , Tianyu Yang , Junfeng Fang , Mingyang Song , Mao Zheng , Haiyun Guo , Dan Zhang , Jinqiao Wang , Tat-Seng Chua

Deep reinforcement learning approaches have shown impressive results in a variety of different domains, however, more complex heterogeneous architectures such as world models require the different neural components to be trained separately…

Neural and Evolutionary Computing · Computer Science 2021-02-24 Sebastian Risi , Kenneth O. Stanley

Causal effect estimation for dynamic treatment regimes (DTRs) contributes to sequential decision making. However, censoring and time-dependent confounding under DTRs are challenging as the amount of observational data declines over time due…

Machine Learning · Statistics 2021-09-27 Adi Lin , Jie Lu , Junyu Xuan , Fujin Zhu , Guangquan Zhang

Miscalibration in deep learning refers to there is a discrepancy between the predicted confidence and performance. This problem usually arises due to the overfitting problem, which is characterized by learning everything presented in the…

Machine Learning · Computer Science 2024-07-16 Zongbo Han , Yifeng Yang , Changqing Zhang , Linjun Zhang , Joey Tianyi Zhou , Qinghua Hu

Standard deep neural networks (DNNs) are commonly trained in an end-to-end fashion for specific tasks such as object recognition, face identification, or character recognition, among many examples. This specificity often leads to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Raphaël Achddou , J. Matias di Martino , Guillermo Sapiro