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The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms…

Deep learning analyses have offered sensitivity leaps in detection of cognitive states from functional MRI (fMRI) measurements across the brain. Yet, as deep models perform hierarchical nonlinear transformations on their input, interpreting…

Signal Processing · Electrical Eng. & Systems 2023-07-20 Hasan Atakan Bedel , Tolga Çukur

Diffusion-weighted imaging (DWI) is a powerful non-invasive tool which is widely used in clinical routine. Mostly, apparent diffusion coefficient maps are acquired, which cannot be directly related to cellular structure. More recently it…

Diffusion tensor imaging (DTI) is a novel modality of magnetic resonance imaging that allows noninvasive mapping of the brain's white matter. A particular map derived from DTI measurements is a map of water principal diffusion directions,…

Applications · Statistics 2008-12-18 Armin Schwartzman , Robert F. Dougherty , Jonathan E. Taylor

We demonstrate the experimental determination of the diffusion propagator using magnetic resonance (MR) techniques. To this end, a recently introduced method was implemented on a benchtop MR scanner and incorporated into profiling and…

Materials Science · Physics 2021-07-01 Alfredo Miguel Ordinola Santisteban , Evren Özarslan

Purpose: Diffusion Magnetic Resonance Imaging (dMRI) is confounded by its long acquisition duration, thereby thwarting the detection of rapid microstructural changes, especially when diffusivity variations are accompanied by rapid changes…

Medical Physics · Physics 2019-03-21 Andrada Ianuş , Noam Shemesh

Performing magnetic resonance imaging (MRI) reconstruction from under-sampled k-space data can accelerate the procedure to acquire MRI scans and reduce patients' discomfort. The reconstruction problem is usually formulated as a denoising…

Image and Video Processing · Electrical Eng. & Systems 2023-12-11 Tianqi Xiang , Wenjun Yue , Yiqun Lin , Jiewen Yang , Zhenkun Wang , Xiaomeng Li

Objective: Most deep neural network-based diffusion tensor imaging methods require the diffusion gradients' number and directions in the data to be reconstructed to match those in the training data. This work aims to develop and evaluate a…

Image and Video Processing · Electrical Eng. & Systems 2023-12-22 Zejun Wu , Jiechao Wang , Zunquan Chen , Qinqin Yang , Zhen Xing , Dairong Cao , Jianfeng Bao , Taishan Kang , Jianzhong Lin , Shuhui Cai , Zhong Chen , Congbo Cai

Magnetic Resonance Imaging (MRI) plays a crucial role in brain disease diagnosis, but it is not always feasible for certain patients due to physical or clinical constraints. Recent studies attempt to synthesize MRI from Computed Tomography…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Junming Liu , Yifei Sun , Weihua Cheng , Yujin Kang , Yirong Chen , Ding Wang , Guosun Zeng

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

Magnetic Resonance Imaging (MRI) has become one of the most important tools to screen humans in medicine, virtually every modern hospital is equipped with an NMR tomograph. The potential of NMR in 3D imaging tasks is by far greater, but…

Soft Condensed Matter · Physics 2018-09-14 Ralf Stannarius

Magnetic resonance imaging technique known as DWI (diffusion-weighted imaging) allows measurement of water diffusivity on a pixel basis for evaluating pathology throughout the body and is now routinely incorporated into many body MRI…

Medical Physics · Physics 2016-11-28 Andrea Barucci , Roberto Carpi , Marco Esposito , Maristella Olmastroni , Giovanna Zatelli

Diffusion tensor imaging (DTI) is a widely used method for studying brain white matter development and degeneration. However, standard DTI estimation methods depend on a large number of high-quality measurements. This would require long…

Image and Video Processing · Electrical Eng. & Systems 2022-11-16 Davood Karimi , Ali Gholipour

Magnetic Resonance (MR) image reconstruction from under-sampled acquisition promises faster scanning time. To this end, current State-of-The-Art (SoTA) approaches leverage deep neural networks and supervised training to learn a recovery…

Image and Video Processing · Electrical Eng. & Systems 2022-03-14 Cheng Peng , Pengfei Guo , S. Kevin Zhou , Vishal Patel , Rama Chellappa

Magnetic Resonance Imaging (MRI) is a powerful, non-invasive diagnostic tool; however, its clinical applicability is constrained by prolonged acquisition times. Whilst present deep learning-based approaches have demonstrated potential in…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Anurag Malyala , Zhenlin Zhang , Chengyan Wang , Chen Qin

Diffusion Magnetic Resonance Imaging (dMRI) plays a crucial role in the noninvasive investigation of tissue microstructural properties and structural connectivity in the \textit{in vivo} human brain. However, to effectively capture the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-04 Jing Yang , Jian Cheng , Cheng Li , Wenxin Fan , Juan Zou , Ruoyou Wu , Shanshan Wang

High-resolution (HR) MRI scans obtained from research-grade medical centers provide precise information about imaged tissues. However, routine clinical MRI scans are typically in low-resolution (LR) and vary greatly in contrast and spatial…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Jueqi Wang , Jacob Levman , Walter Hugo Lopez Pinaya , Petru-Daniel Tudosiu , M. Jorge Cardoso , Razvan Marinescu

Quantifying muscle tissue properties is crucial for understanding pathophysiological changes occurring in skeletal muscle (SM). In particular, T2 relaxation and diffusion MRI (dMRI) are promising techniques. However, typical methods measure…

Diffusion MRI (dMRI) provides a distinctive means to probe the microstructural architecture of living tissue, facilitating applications such as brain connectivity analysis, modeling across multiple conditions, and the estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Jongyeon Yoon , Elyssa M. McMaster , Michael E. Kim , Gaurav Rudravaram , Kurt G. Schilling , Bennett A. Landman , Daniel Moyer

MRI provides a unique non-invasive window into the brain, yet is limited to millimeter resolution, orders of magnitude coarser than cell dimensions. Here we show that diffusion MRI is sensitive to the micrometer-scale variations in axon…

Medical Physics · Physics 2020-07-10 Hong-Hsi Lee , Antonios Papaioannou , Sung-Lyoung Kim , Dmitry S. Novikov , Els Fieremans
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