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Retrosynthesis, which aims to identify viable synthetic pathways for target molecules by decomposing them into simpler precursors, is often treated as a search problem. However, its complexity arises from multi-branched tree-structured…

Artificial Intelligence · Computer Science 2025-11-25 Chengyang Tian , Yuhang Chang , Yangpeng Zhang , Yang Liu

A coding of functions that allows a genetic algorithm to minimize functionals without analytic trial functions is presented and implemented for solving numerically some instances of variational problems from physics.

Computational Physics · Physics 2007-05-23 Carlos D. Toledo

Most of the problems in genetic algorithms are very complex and demand a large amount of resources that current technology can not offer. Our purpose was to develop a Java-JINI distributed library that implements Genetic Algorithms with…

Neural and Evolutionary Computing · Computer Science 2016-05-24 Marco AR Erra , Pedro MM Mitra , Agostinho C Rosa

By analogy with Monte Carlo algorithms, we propose new strategies for design and redesign of small molecule libraries in high-throughput experimentation, or combinatorial chemistry. Several Monte Carlo methods are examined, including…

Statistical Mechanics · Physics 2007-05-23 Ligang Chen , Michael W. Deem

In the context of evolutionary quantum computing in the literal meaning, a quantum crossover operation has not been introduced so far. Here, we introduce a novel quantum genetic algorithm which has a quantum crossover procedure performing…

Neural and Evolutionary Computing · Computer Science 2014-02-05 Akira SaiToh , Robabeh Rahimi , Mikio Nakahara

Autonomous materials discovery with desired properties is one of the ultimate goals for materials science, and the current studies have been focusing mostly on high-throughput screening based on density functional theory calculations and…

Genetic Algorithms are introduced as a search method for finding string vacua with viable phenomenological properties. It is shown, by testing them against a class of Free Fermionic models, that they are orders of magnitude more efficient…

High Energy Physics - Theory · Physics 2015-06-19 Steven Abel , John Rizos

We investigate the ability of a genetic algorithm to design cellular automata that perform computations. The computational strategies of the resulting cellular automata can be understood using a framework in which ``particles'' embedded in…

adap-org · Physics 2015-06-30 James P. Crutchfield , Melanie Mitchell , Rajarshi Das

This work was inspired by author experiences with a telescope scheduling. Author long time goal is to develop and further extend software for an autonomous observatory. The software shall provide users with all the facilities they need to…

Artificial Intelligence · Computer Science 2010-02-02 Petr Kubanek

Syntax-guided synthesis is a paradigm in program synthesis in which the search space of candidate solutions is constrained by a syntactic template in the form of a grammar. These syntactic constraints serve two purposes: constraining the…

Software Engineering · Computer Science 2023-06-06 Yixuan Li , Federico Mora , Elizabeth Polgreen , Sanjit A. Seshia

Molecular discovery, when formulated as an optimization problem, presents significant computational challenges because optimization objectives can be non-differentiable. Evolutionary Algorithms (EAs), often used to optimize black-box…

We present a genetic algorithm which is distributed in two novel ways: along genotype and temporal axes. Our algorithm first distributes, for every member of the population, a subset of the genotype to each network node, rather than a…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Minkyu Kim , Varun Aggarwal , Una-May O'Reilly , Muriel Medard

We present a non-parametric technique to infer the projected-mass distribution of a gravitational lens system with multiple strong-lensed images. The technique involves a dynamic grid in the lens plane on which the mass distribution of the…

Astrophysics · Physics 2009-11-11 J. Liesenborgs , S. De Rijcke , H. Dejonghe

Over the last decade, wireless networks have experienced an impressive growth and now play a main role in many telecommunications systems. As a consequence, scarce radio resources, such as frequencies, became congested and the need for…

Optimization and Control · Mathematics 2017-04-19 Fabio D'Andreagiovanni

Structure-based drug design (SBDD) aims to discover drug candidates by finding molecules (ligands) that bind tightly to a disease-related protein (targets), which is the primary approach to computer-aided drug discovery. Recently, applying…

Quantitative Methods · Quantitative Biology 2022-12-01 Tianfan Fu , Wenhao Gao , Connor W. Coley , Jimeng Sun

Finding a globally optimal Bayesian Network using exhaustive search is a problem with super-exponential complexity, which severely restricts the number of variables that it can work for. We implement a dynamic programming based algorithm…

Artificial Intelligence · Computer Science 2022-07-19 Nand Sharma , Joshua Millstein

The optimization of dynamic problems is both widespread and difficult. When conducting dynamic optimization, a balance between reinitialization and computational expense has to be found. There are multiple approaches to this. In parallel…

Neural and Evolutionary Computing · Computer Science 2014-01-21 Ronald Hochreiter , Christoph Waldhauser

Thin-film solar cells are predominately designed similar to a stacked structure. Optimizing the layer thicknesses in this stack structure is crucial to extract the best efficiency of the solar cell. The commonplace method used in…

Neural and Evolutionary Computing · Computer Science 2020-04-08 Premkumar Vincent , Gwenaelle Cunha Sergio , Jaewon Jang , In Man Kang , Jaehoon Park , Hyeok Kim , Minho Lee , Jin-Hyuk Bae

A quantum algorithm for general combinatorial search that uses the underlying structure of the search space to increase the probability of finding a solution is presented. This algorithm shows how coherent quantum systems can be matched to…

Quantum Physics · Physics 2009-10-30 Tad Hogg

Intelligent routing in networks has opened up many challenges in modelling and methods, over the past decade. Many techniques do exist for routing on such an environment where path determination was carried out by advertisement, position…

Networking and Internet Architecture · Computer Science 2014-08-07 T. R. Gopalakrishnan Nair , Kavitha Sooda
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