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Multiplexed imaging data are revolutionizing our understanding of the composition and organization of tissues and tumors. A critical aspect of such tissue profiling is quantifying the spatial relationship relationships among cells at…

Quantitative Methods · Quantitative Biology 2024-05-06 Ajit J. Nirmal , Peter K. Sorger

Recently, machine learning methods have gained significant traction in scientific computing, particularly for solving Partial Differential Equations (PDEs). However, methods based on deep neural networks (DNNs) often lack convergence…

Artificial Intelligence · Computer Science 2025-06-16 Li Liu , Heng Yong

This paper describes several improvements to a new method for signal decomposition that we recently formulated under the name of Differentiable Dictionary Search (DDS). The fundamental idea of DDS is to exploit a class of powerful deep…

Audio and Speech Processing · Electrical Eng. & Systems 2022-11-29 Lukáš Samuel Marták , Rainer Kelz , Gerhard Widmer

Similarity search finds objects that are similar to a given query object based on a similarity metric. As the amount and variety of data continue to grow, similarity search in metric spaces has gained significant attention. Metric spaces…

Databases · Computer Science 2024-10-08 Yifan Zhu , Chengyang Luo , Tang Qian , Lu Chen , Yunjun Gao , Baihua Zheng

Feature selection is essential for high-dimensional biomedical data, enabling stronger predictive performance, reduced computational cost, and improved interpretability in precision medicine applications. Existing approaches face notable…

Machine Learning · Computer Science 2026-01-07 Xiaoyan Sun , Qingyu Meng , Yalu Wen

Understanding complex phenomena often requires analyzing high-dimensional data to uncover emergent properties that arise from multifactorial interactions. Here, we present EMUSES (Emerging-properties Mapping Using Spatial Embedding…

Emerging Technologies · Computer Science 2024-06-21 Chris Foulon , Marcela Ovando-Tellez , Lia Talozzi , Maurizio Corbetta , Anna Matsulevits , Michel Thiebaut de Schotten

Deep Frequency Modulation Interferometry (DFMI) is an emerging laser interferometry technique for high-precision metrology, offering picometer-level displacement measurements and the potential for absolute length determination with…

Instrumentation and Detectors · Physics 2025-11-21 Miguel Dovale-Álvarez

Progressive dimensionality reduction algorithms allow for visually investigating intermediate results, especially for large data sets. While different algorithms exist that progressively increase the number of data points, we propose an…

Graphics · Computer Science 2024-10-28 Marina Evers , David Hägele , Sören Döring , Daniel Weiskopf

Aims: The interactive software package iCosmo, designed to perform cosmological calculations is described. Methods: iCosmo is a software package to perform interactive cosmological calculations for the low redshift universe. Computing…

Astrophysics · Physics 2015-05-13 Alexandre Refregier , Adam Amara , Thomas Kitching , Anais Rassat

Database-search algorithms, that deduce peptides from Mass Spectrometry (MS) data, have tried to improve the computational efficiency to accomplish larger, and more complex systems biology studies. Existing serial, and high-performance…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-02-08 Muhammad Haseeb , Fahad Saeed

We present an end-to-end differentiable molecular simulation framework (DIMOS) for molecular dynamics and Monte Carlo simulations. DIMOS easily integrates machine-learning-based interatomic potentials and implements classical force fields…

We propose new methodologies in multi-dimensional unfolding in dense environments, and show that incorporating auxiliary observables can significantly improve performance. Our approach builds on the ML-based OmniFold algorithm, which we…

High Energy Physics - Phenomenology · Physics 2025-07-10 Alexandre Falcão , Adam Takacs

Machine learning methods are used to discover complex nonlinear relationships in biological and medical data. However, sophisticated learning models are computationally unfeasible for data with millions of features. Here we introduce the…

DADApy is a python software package for analysing and characterising high-dimensional data manifolds. It provides methods for estimating the intrinsic dimension and the probability density, for performing density-based clustering and for…

Mass spectrometry is the dominant technology in the field of proteomics, enabling high-throughput analysis of the protein content of complex biological samples. Due to the complexity of the instrumentation and resulting data, sophisticated…

Denoising Diffusion Probabilistic Models (DDPM) are powerful state-of-the-art methods used to generate synthetic data from high-dimensional data distributions and are widely used for image, audio, and video generation as well as many more…

Machine Learning · Statistics 2025-04-25 Iskander Azangulov , George Deligiannidis , Judith Rousseau

Infrared-visible object detection aims to achieve robust even full-day object detection by fusing the complementary information of infrared and visible images. However, highly dynamically variable complementary characteristics and commonly…

Computer Vision and Pattern Recognition · Computer Science 2024-03-08 Junjie Guo , Chenqiang Gao , Fangcen Liu , Deyu Meng , Xinbo Gao

Deep learning methods have played a more and more important role in hyperspectral image classification. However, the general deep learning methods mainly take advantage of the information of sample itself or the pairwise information between…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Zhiqiang Gong , Weidong Hu , Xiaoyong Du , Ping Zhong , Panhe Hu

Depth information is useful for many applications. Active depth sensors are appealing because they obtain dense and accurate depth maps. However, due to issues that range from power constraints to multi-sensor interference, these sensors…

Image and Video Processing · Electrical Eng. & Systems 2020-02-04 James Noraky , Vivienne Sze

Mass spectrometry imaging (MSI) as an analytical tool for bio-molecular and bio-medical research targets, accurate compound localization and identification. In terms of dedicated instrumentation, this translates into the demand for more…

Instrumentation and Detectors · Physics 2013-05-24 Julia H. Jungmann , Ron M. A. Heeren