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Lead optimization in drug discovery requires efficiently navigating vast chemical space through iterative cycles to enhance molecular properties while preserving structural similarity to the original lead compound. Despite recent advances,…

Machine Learning · Computer Science 2025-09-29 Ziqing Wang , Yibo Wen , William Pattie , Xiao Luo , Weimin Wu , Jerry Yao-Chieh Hu , Abhishek Pandey , Han Liu , Kaize Ding

Chest X-Ray (CXR) is a widely used clinical imaging modality and has a pivotal role in the diagnosis and prognosis of various lung and heart related conditions. Conventional automated clinical diagnostic tool design strategies relying on…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Abhijeet Parida , Daniel Capellan-Martin , Sara Atito , Muhammad Awais , Maria J. Ledesma-Carbayo , Marius G. Linguraru , Syed Muhammad Anwar

Real-world categorization is severely hampered by class imbalance because traditional ensembles favor majority classes, which lowers minority performance and overall F1-score. We provide a unique ensemble technique for imbalanced problems…

Computation and Language · Computer Science 2026-04-14 Mohamed Ehab , Ali Hamdi , Khaled Shaban

This paper considers a novel application of deep AUC maximization (DAM) for multi-instance learning (MIL), in which a single class label is assigned to a bag of instances (e.g., multiple 2D slices of a CT scan for a patient). We address a…

Machine Learning · Computer Science 2023-06-07 Dixian Zhu , Bokun Wang , Zhi Chen , Yaxing Wang , Milan Sonka , Xiaodong Wu , Tianbao Yang

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Zhekai Zhou , Guibo Luo , Mingzhi Chen , Zhenyu Weng , Yuesheng Zhu

In this paper, we propose a zoom-out-and-in network for generating object proposals. A key observation is that it is difficult to classify anchors of different sizes with the same set of features. Anchors of different sizes should be placed…

Computer Vision and Pattern Recognition · Computer Science 2018-06-11 Hongyang Li , Yu Liu , Wanli Ouyang , Xiaogang Wang

Decision making algorithms are used in a multitude of different applications. Conventional approaches for designing decision algorithms employ principled and simplified modelling, based on which one can determine decisions via tractable…

Signal Processing · Electrical Eng. & Systems 2022-06-23 Nir Shlezinger , Yonina C. Eldar , Stephen P. Boyd

Real-world applications involve various discrete optimization problems. Designing a specialized optimizer for each of these problems is challenging, typically requiring significant domain knowledge and human efforts. Hence, developing…

Neural and Evolutionary Computing · Computer Science 2024-05-30 Shengcai Liu , Zhiyuan Wang , Yew-Soon Ong , Xin Yao , Ke Tang

This study presents a novel multi-output classification (MOC) framework designed for domain adaptation in fault diagnosis, addressing challenges posed by partially labeled (PL) target domain dataset and coexisting faults in rotating…

Machine Learning · Computer Science 2025-04-16 Wonjun Yi , Yong-Hwa Park

In this paper, we have proposed a novel algorithm for identifying the modulation scheme of an unknown incoming signal in order to mitigate the interference with primary user in Cognitive Radio systems, which is facilitated by using…

Signal Processing · Electrical Eng. & Systems 2018-06-21 K. Pavan Kumar Reddy , K. Lakhan Shiva , K. Abhilash , Y. Yoganandam

Many real-world classification tasks require predicting multiple labels per instance, necessitating the optimization of complex evaluation metrics such as the $F$-measure and Jaccard index. While the Empirical Utility Maximization (EUM)…

Machine Learning · Computer Science 2026-05-28 Mehryar Mohri , Yutao Zhong

This study investigates the applicability of 3D dose predictions from a model trained on one modality to a cross-modality automated planning workflow. Additionally, we explore the impact of integrating a multi-criteria optimizer on adapting…

Medical Physics · Physics 2024-02-26 Gregory Szalkowski , Xuanang Xu , Shiva Das , Pew-Thian Yap , Jun Lian

Magnetic resonance (MR) imaging offers a wide variety of imaging techniques. A large amount of data is created per examination which needs to be checked for sufficient quality in order to derive a meaningful diagnosis. This is a manual…

Polycystic Ovary Syndrome (PCOS) is a widespread disorder in women of reproductive age, characterized by a hormonal imbalance, irregular periods, and multiple ovarian cysts. Infertility, metabolic syndrome, and cardiovascular risks are…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Shayan Abrar , Samura Rahman , Ishrat Jahan Momo , Mahjabin Tasnim Samiha , B. M. Shahria Alam , Mohammad Tahmid Noor , Nishat Tasnim Niloy

Multi-modal learning is typically performed with network architectures containing modality-specific layers and shared layers, utilizing co-registered images of different modalities. We propose a novel learning scheme for unpaired…

Computer Vision and Pattern Recognition · Computer Science 2020-01-10 Qi Dou , Quande Liu , Pheng Ann Heng , Ben Glocker

Out-of-distribution (OOD) detection aims to detect testing samples far away from the in-distribution (ID) training data, which is crucial for the safe deployment of machine learning models in the real world. Distance-based OOD detection…

Machine Learning · Computer Science 2024-02-06 Haodong Lu , Dong Gong , Shuo Wang , Jason Xue , Lina Yao , Kristen Moore

One of the most noticeable trends in healthcare over the last years is the continuous growth of data volume produced and its heterogeneity. In the medical imaging field, the evolution of digital systems is supported by the PACS concept and…

Software Engineering · Computer Science 2021-01-05 Rui Lebre , Eduardo Pinho , Jorge Miguel Silva , Carlos Costa

Accurate breast lesion risk estimation can significantly reduce unnecessary biopsies and help doctors decide optimal treatment plans. Most existing computer-aided systems rely solely on mammogram features to classify breast lesions. While…

Image and Video Processing · Electrical Eng. & Systems 2021-08-24 Hung Q. Vo , Pengyu Yuan , Tiancheng He , Stephen T. C. Wong , Hien V. Nguyen

Machine learning in medical imaging during clinical routine is impaired by changes in scanner protocols, hardware, or policies resulting in a heterogeneous set of acquisition settings. When training a deep learning model on an initial…

Computer Vision and Pattern Recognition · Computer Science 2022-03-16 Matthias Perkonigg , Johannes Hofmanninger , Christian Herold , Helmut Prosch , Georg Langs

Segment Anything Model (SAM), a prompt-driven foundation model for natural image segmentation, has demonstrated impressive zero-shot performance. However, SAM does not work when directly applied to medical image segmentation, since SAM…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Bin Xie , Hao Tang , Bin Duan , Dawen Cai , Yan Yan , Gady Agam