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The embedding of Biomedical Knowledge Graphs (BKGs) generates robust representations, valuable for a variety of artificial intelligence applications, including predicting drug combinations and reasoning disease-drug relationships.…

Databases · Computer Science 2023-10-17 Zhiguang Fan , Yuedong Yang , Mingyuan Xu , Hongming Chen

Graph contrastive learning (GCL) has emerged as an effective tool for learning unsupervised representations of graphs. The key idea is to maximize the agreement between two augmented views of each graph via data augmentation. Existing GCL…

Machine Learning · Computer Science 2022-09-16 Xin Zhang , Qiaoyu Tan , Xiao Huang , Bo Li

Drug-target binding affinity prediction plays an important role in the early stages of drug discovery, which can infer the strength of interactions between new drugs and new targets. However, the performance of previous computational models…

Machine Learning · Computer Science 2023-07-19 Xinxing Yang , Genke Yang , Jian Chu

Recent work has shown the potential of graph neural networks to efficiently predict material properties, enabling high-throughput screening of materials. Training these models, however, often requires large quantities of labelled data,…

Machine Learning · Computer Science 2022-11-28 Teddy Koker , Keegan Quigley , Will Spaeth , Nathan C. Frey , Lin Li

Graph contrastive learning (GCL) has emerged as a pivotal technique in the domain of graph representation learning. A crucial aspect of effective GCL is the caliber of generated positive and negative samples, which is intrinsically dictated…

Machine Learning · Computer Science 2024-02-19 Xinjian Zhao , Liang Zhang , Yang Liu , Ruocheng Guo , Xiangyu Zhao

Accurate molecular property prediction requires integrating complementary information from molecular structure and chemical semantics. In this work, we propose LGM-CL, a local-global multimodal contrastive learning framework that jointly…

Machine Learning · Computer Science 2026-02-02 Xiayu Liu , Zhengyi Lu , Yunhong Liao , Chan Fan , Hou-biao Li

Graph Contrastive Learning (GCL) has recently drawn much research interest for learning generalizable node representations in a self-supervised manner. In general, the contrastive learning process in GCL is performed on top of the…

Machine Learning · Computer Science 2022-12-06 Kaize Ding , Yancheng Wang , Yingzhen Yang , Huan Liu

Graph contrastive learning (GCL), learning the node representation by contrasting two augmented graphs in a self-supervised way, has attracted considerable attention. GCL is usually believed to learn the invariant representation. However,…

Machine Learning · Computer Science 2024-03-08 Yanhu Mo , Xiao Wang , Shaohua Fan , Chuan Shi

Recent advancements in Graph Contrastive Learning (GCL) have demonstrated remarkable effectiveness in improving graph representations. However, relying on predefined augmentations (e.g., node dropping, edge perturbation, attribute masking)…

Machine Learning · Computer Science 2025-02-27 Khaled Mohammed Saifuddin , Shihao Ji , Esra Akbas

Contrastive learning has emerged as a powerful tool for graph representation learning. However, most contrastive learning methods learn features of graphs with fixed coarse-grained scale, which might underestimate either local or global…

Machine Learning · Computer Science 2022-10-24 Jun Wang , Weixun Li , Changyu Hou , Xin Tang , Yixuan Qiao , Rui Fang , Pengyong Li , Peng Gao , Guotong Xie

We propose $\textbf{MGCL}$, a model-driven graph contrastive learning (GCL) framework that leverages graphons (probabilistic generative models for graphs) to guide contrastive learning by accounting for the data's underlying generative…

Machine Learning · Computer Science 2025-06-09 Ali Azizpour , Nicolas Zilberstein , Santiago Segarra

Graph contrastive learning has emerged as a powerful technique for learning graph representations that are robust and discriminative. However, traditional approaches often neglect the critical role of subgraph structures, particularly the…

Machine Learning · Computer Science 2025-03-14 Tianhao Peng , Xuhong Li , Haitao Yuan , Yuchen Li , Haoyi Xiong

Molecular representation learning is vital for various downstream applications, including the analysis and prediction of molecular properties and side effects. While Graph Neural Networks (GNNs) have been a popular framework for modeling…

Machine Learning · Computer Science 2025-02-18 Pengcheng Jiang , Cao Xiao , Tianfan Fu , Parminder Bhatia , Taha Kass-Hout , Jimeng Sun , Jiawei Han

Graph Contrastive Learning (GCL) has emerged as a powerful paradigm for training Graph Neural Networks (GNNs) in the absence of task-specific labels. However, its scalability on large-scale graphs is hindered by the intensive message…

Machine Learning · Computer Science 2025-11-12 Xiang Chen , Kun Yue , Wenjie Liu , Zhenyu Zhang , Liang Duan

Incorporating Knowledge Graphs (KG) into recommeder system has attracted considerable attention. Recently, the technical trend of Knowledge-aware Recommendation (KGR) is to develop end-to-end models based on graph neural networks (GNNs).…

Information Retrieval · Computer Science 2022-08-23 Ding Zou , Wei Wei , Ziyang Wang , Xian-Ling Mao , Feida Zhu , Rui Fang , Dangyang Chen

Molecular representation learning (MRL) is a key step to build the connection between machine learning and chemical science. In particular, it encodes molecules as numerical vectors preserving the molecular structures and features, on top…

Quantitative Methods · Quantitative Biology 2023-11-30 Zhichun Guo , Kehan Guo , Bozhao Nan , Yijun Tian , Roshni G. Iyer , Yihong Ma , Olaf Wiest , Xiangliang Zhang , Wei Wang , Chuxu Zhang , Nitesh V. Chawla

Graph contrastive learning (CL) methods learn node representations in a self-supervised manner by maximizing the similarity between the augmented node representations obtained via a GNN-based encoder. However, CL methods perform poorly on…

Machine Learning · Computer Science 2024-06-12 Wenhan Yang , Baharan Mirzasoleiman

The versatility of multimodal deep learning holds tremendous promise for advancing scientific research and practical applications. As this field continues to evolve, the collective power of cross-modal analysis promises to drive…

Machine Learning · Computer Science 2025-05-15 Yifei Wang , Yunrui Li , Lin Liu , Pengyu Hong , Hao Xu

We present a collaborative learning method called Mutual Contrastive Learning (MCL) for general visual representation learning. The core idea of MCL is to perform mutual interaction and transfer of contrastive distributions among a cohort…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Chuanguang Yang , Zhulin An , Linhang Cai , Yongjun Xu

Contrastive learning has been widely applied to graph representation learning, where the view generators play a vital role in generating effective contrastive samples. Most of the existing contrastive learning methods employ pre-defined…

Machine Learning · Computer Science 2022-01-04 Yihang Yin , Qingzhong Wang , Siyu Huang , Haoyi Xiong , Xiang Zhang