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Precision oncology aims to prescribe the optimal cancer treatment to the right patients, maximizing therapeutic benefits. However, identifying patient subgroups that may benefit more from experimental cancer treatments based on randomized…

Methodology · Statistics 2026-01-06 Xingyu Li , Qing Liu , Tony Jiang , Hong Amy Xia , Peng Wei , Brian P. Hobbs

We address the problem of finding influential training samples for a particular case of tree ensemble-based models, e.g., Random Forest (RF) or Gradient Boosted Decision Trees (GBDT). A natural way of formalizing this problem is studying…

Machine Learning · Computer Science 2018-03-14 Boris Sharchilev , Yury Ustinovsky , Pavel Serdyukov , Maarten de Rijke

Tree-structured models are a powerful alternative to parametric regression models if non-linear effects and interactions are present in the data. Yet, classical tree-structured models might not be appropriate if data comes in clusters of…

Methodology · Statistics 2025-01-23 Nikolai Spuck , Matthias Schmid , Moritz Berger

Treatment effects in a wide range of economic, environmental, and epidemiological applications often vary across space, and understanding the heterogeneity of causal effects across space and outcome quantiles is a critical challenge in…

Methodology · Statistics 2025-09-03 Yan Gong , Reetam Majumder , Brian J. Reich , Raphaël Huser

We introduce a novel interpretable tree based algorithm for prediction in a regression setting. Our motivation is to estimate the unknown regression function from a functional decomposition perspective in which the functional components…

Machine Learning · Statistics 2023-08-04 Munir Hiabu , Enno Mammen , Joseph T. Meyer

Multinomial processing tree (MPT) models are tools for disentangling the contributions of latent cognitive processes in a given experimental paradigm. The present note analyzes MPT models subject to order constraints on subsets of its…

Applications · Statistics 2014-11-11 Karl Christoph Klauer , Henrik Singmann , David Kellen

A compositional tree refers to a tree structure on a set of random variables where each random variable is a node and composition occurs at each non-leaf node of the tree. As a generalization of compositional data, compositional trees…

Methodology · Statistics 2021-04-20 Bingkai Wang , Brian S. Caffo , Xi Luo , Chin-Fu Liu , Andreia V. Faria , Michael I. Miller , Yi Zhao

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

A random forest prediction can be computed by the scalar product of the labels of the training examples and a set of weights that are determined by the leafs of the forest into which the test object falls; each prediction can hence be…

Machine Learning · Computer Science 2023-11-27 Henrik Boström

Estimating heterogeneous treatment effects is critical in domains such as personalized medicine, resource allocation, and policy evaluation. A central challenge lies in identifying subpopulations that respond differently to interventions,…

Machine Learning · Statistics 2025-09-18 Zilong Wang , Turgay Ayer , Shihao Yang

Tree-based machine learning models such as random forests, decision trees, and gradient boosted trees are the most popular non-linear predictive models used in practice today, yet comparatively little attention has been paid to explaining…

Random forests have proven to be reliable predictive algorithms in many application areas. Not much is known, however, about the statistical properties of random forests. Several authors have established conditions under which their…

Statistics Theory · Mathematics 2016-05-05 Stefan Wager

Random forests are powerful non-parametric regression method but are severely limited in their usage in the presence of randomly censored observations, and naively applied can exhibit poor predictive performance due to the incurred biases.…

Machine Learning · Statistics 2019-02-12 Alexander Hanbo Li , Jelena Bradic

When a strict subset of covariates are given, we propose conditional quantile treatment effect to capture the heterogeneity of treatment effects via the quantile sheet that is the function of the given covariates and quantile. We focus on…

Statistics Theory · Mathematics 2020-09-23 Niwen Zhou , Xu Guo , Lixing Zhu

In ordinary quantile regression, quantiles of different order are estimated one at a time. An alternative approach, which is referred to as quantile regression coefficients modeling (QRCM), is to model quantile regression coefficients as…

Methodology · Statistics 2020-06-02 Paolo Frumento , Matteo Bottai , Iván Fernández-Val

The most fundamental problem in statistical causality is determining causal relationships from limited data. Probability trees, which combine prior causal structures with Bayesian updates, have been suggested as a possible solution. In this…

Machine Learning · Computer Science 2022-05-19 Tue Herlau

Machine learning methods for estimating treatment effect heterogeneity promise greater flexibility than existing methods that test a few pre-specified hypotheses. However, one problem these methods can have is that it can be challenging to…

Econometrics · Economics 2024-08-05 Patrick Rehill

We develop a finite-sample, design-based theory for random forests in which each tree is a randomized conditional predictor acting on fixed covariates and the forest is their Monte Carlo average. An exact variance identity separates Monte…

Machine Learning · Statistics 2026-03-03 Nathaniel S. O'Connell

Out-Of-Distribution (OOD) generalization is an essential topic in machine learning. However, recent research is only focusing on the corresponding methods for neural networks. This paper introduces a novel and effective solution for OOD…

Machine Learning · Computer Science 2024-01-19 Yufan Liao , Qi Wu , Xing Yan

We consider conducting inference on the output of the Classification and Regression Tree (CART) [Breiman et al., 1984] algorithm. A naive approach to inference that does not account for the fact that the tree was estimated from the data…

Methodology · Statistics 2022-10-19 Anna C. Neufeld , Lucy L. Gao , Daniela M. Witten