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We show that a quantum phase transition from ergodic to many-body localized (MBL) phases can be induced via periodic pulsed manipulation of spin systems. Such a transition is enabled by the interplay between weak disorder and slow heating…

Disordered Systems and Neural Networks · Physics 2018-03-28 Soonwon Choi , Dmitry A. Abanin , Mikhail D. Lukin

Binding free energies are a key element in understanding and predicting the strength of protein--drug interactions. While classical free energy simulations yield good results for many purely organic ligands, drugs including transition metal…

We present a fully analytical description of a many body localization (MBL) transition in a microscopically defined model. Its Hamiltonian is the sum of one- and two-body operators, where both contributions obey a maximum-entropy principle…

Strongly Correlated Electrons · Physics 2021-01-13 Felipe Monteiro , Tobias Micklitz , Masaki Tezuka , Alexander Altland

Computational quantum mechanics based molecular and materials design campaigns consume increasingly more high-performance compute resources, making improved job scheduling efficiency desirable in order to reduce carbon footprint or wasteful…

Chemical Physics · Physics 2020-06-15 Stefan Heinen , Max Schwilk , Guido Falk von Rudorff , O. Anatole von Lilienfeld

Polymer reference interaction site model (PRISM) theory, a descendent of Ornstein-Zernike liquid state theory, is a powerful tool to predict the structure and thermodynamics of equilibrium polymer systems, but its accuracy and applicability…

Soft Condensed Matter · Physics 2025-11-19 Zhihao Feng , Christian T. Randolph , Tyler B. Martin , Thomas E. Gartner

All simulation approaches eventually face limits in computational scalability when applied to large spatiotemporal domains. This challenge becomes especially apparent in molecular-level particle simulations, where high spatial and temporal…

Computational Physics · Physics 2025-10-23 Matthias Busch , Gregor Häfner , Jiayu Xie , Marius Tacke , Marcus Müller , Christian J. Cyron , Roland C. Aydin

Large-scale Monte Carlo simulations of a phase-separating colloid-polymer mixture are performed and compared to recent experiments. The approach is based on effective interaction potentials in which the central monomers of self-avoiding…

Soft Condensed Matter · Physics 2007-05-23 R. L. C. Vink , A. Jusufi , J. Dzubiella , C. N. Likos

Machine learning (ML) architectures such as convolutional neural networks (CNNs) have garnered considerable recent attention in the study of quantum many-body systems. However, advanced ML approaches such as transfer learning have seldom…

Statistical Mechanics · Physics 2020-03-10 Zewang Zhang , Shuo Yang , Yi-hang Wu , Chenxi Liu , Yimin Han , Ching Hua Lee , Zheng Sun , Guangjie Li , Xiao Zhang

We review methods that allow one to detect and characterise quantum correlations in many-body systems, with a special focus on approaches which are scalable. Namely, those applicable to systems with many degrees of freedom, without…

Quantum Physics · Physics 2023-09-28 Irénée Frérot , Matteo Fadel , Maciej Lewenstein

Artificial Intelligence (AI) and Machine Learning (ML) are weaving their way into the fabric of society, where they are playing a crucial role in numerous facets of our lives. As we witness the increased deployment of AI and ML in various…

Emerging Technologies · Computer Science 2022-12-23 Sasitharan Balasubramaniam , Samitha Somathilaka , Sehee Sun , Adrian Ratwatte , Massimiliano Pierobon

Understanding the complex behavior of molecular systems is fundamental to fields such as physics, materials science, and biology. Molecular dynamics (MD) simulations are crucial tools for studying atomic-level dynamics. This work focuses on…

Computational Engineering, Finance, and Science · Computer Science 2025-07-16 David Martin , Samuel James Newcome , Markus Mühlhäußer , Manish Kumar Mishra , Fabio Alexander Gratl , Hans-Joachim Bungartz

Dense suspensions of solid particles in viscous liquid are ubiquitous in both industry and nature, and there is a clear need for efficient numerical routines to simulate their rheology and microstructure. Particles of micron size present a…

Soft Condensed Matter · Physics 2023-07-27 Xuan Li , John R. Royer , Christopher Ness

Accurate modeling of the solvent environment for biological molecules is crucial for computational biology and drug design. A popular approach to achieve long simulation time scales for large system sizes is to incorporate the effect of the…

Computational Physics · Physics 2021-08-27 Yaoyi Chen , Andreas Krämer , Nicholas E. Charron , Brooke E. Husic , Cecilia Clementi , Frank Noé

Recent years have witnessed the fast development of machine learning potentials (MLPs) and their widespread applications in chemistry, physics, and material science. By fitting discrete ab initio data faithfully to continuous and…

Chemical Physics · Physics 2025-05-13 Junfan Xia , Yaolong Zhang , Bin Jiang

The complexity of the interactions between the constituent granular and liquid phases of a suspension requires an adequate treatment of the constituents themselves. A promising way for numerical simulations of such systems is given by…

Soft Condensed Matter · Physics 2015-09-09 A. Leonardi , F. K. Wittel , M. Mendoza , H. J. Herrmann

Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

Machine learning (ML) can be used to construct surrogate models for the fast prediction of a property of interest. ML can thus be applied to chemical projects, where the usual experimentation or calculation techniques can take hours or days…

Suspensions of swimming particles exhibit complex collective behaviors driven by hydrodynamic interactions, showing persistent large-scale flows and long-range correlations. While heavily studied, it remains unclear how such structures…

Soft Condensed Matter · Physics 2025-05-27 Bryce Palmer , Scott Weady , Michael O'Brien , Blakesley Burkhart , Michael J. Shelley

The convergence of statistical learning and molecular physics is transforming our approach to modeling biomolecular systems. Physics-informed machine learning (PIML) offers a systematic framework that integrates data-driven inference with…

Biomolecules · Quantitative Biology 2025-11-11 Aaryesh Deshpande

Rational design of compounds with specific properties requires conceptual understanding and fast evaluation of molecular properties throughout chemical compound space (CCS) -- the huge set of all potentially stable molecules. Recent…

Chemical Physics · Physics 2019-12-02 O. Anatole von Lilienfeld , Klaus-Robert Müller , Alexandre Tkatchenko