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Prediction of critical temperature $(T_c)$ of a superconductor remains a significant challenge in condensed matter physics. While the BCS theory explains superconductivity in conventional superconductors, there is no framework to predict…

Superconductivity · Physics 2026-01-08 Suhas Adiga , Umesh V. Waghmare

We present a method to accurately predict the Helmholtz harmonic free energies of molecular crystals in high-throughput settings. This is achieved by devising a computationally efficient framework that employs a Gaussian Process Regression…

Materials Science · Physics 2021-06-17 Marcin Krynski , Mariana Rossi

Topological materials present unconventional electronic properties that make them attractive for both basic science and next-generation technological applications. The majority of currently known topological materials have been discovered…

Materials Science · Physics 2023-02-14 Andrew Ma , Yang Zhang , Thomas Christensen , Hoi Chun Po , Li Jing , Liang Fu , Marin Soljačić

The computational discovery and design of new crystalline materials, particularly metal-organic frameworks (MOFs), heavily relies on high-quality, computation-ready structural data. However, recent studies have revealed significant error…

Chemical Physics · Physics 2025-10-29 Guobin Zhao , Pengyu Zhao , Yongchul G. Chung

De novo crystal generation, a central task in materials discovery, aims to generate crystals that are simultaneously valid, stable, unique, and novel. Existing methods mainly rely on black-box stochastic sampling, providing limited control…

Despite an artificial intelligence-assisted modeling of disordered crystals is a widely used and well-tried method of new materials design, the issues of its robustness, reliability, and stability are still not resolved and even not…

Computational Physics · Physics 2024-11-08 Fedor S. Avilov , Roman A. Eremin , Semen A. Budennyy , Innokentiy S. Humonen

End-to-end prediction of high-order crystal tensor properties from atomic structures remains challenging: while spherical-harmonic equivariant models are expressive, their Clebsch-Gordan tensor products incur substantial compute and memory…

Machine Learning · Computer Science 2026-02-05 Dian Jin , Yancheng Yuan , Xiaoming Tao

Combinatorial and guided screening of materials space with density-functional theory and related approaches has provided a wealth of hypothetical inorganic materials, which are increasingly tabulated in open databases. The OPTIMADE API is a…

The emergence of deep learning has brought the long-standing goal of comprehensively understanding and exploring crystalline materials closer to reality. Yet, universal exploration across all elements remains hindered by the combinatorial…

Materials Science · Physics 2025-11-18 Fengyu Xie , Ruoyu Wang , Taoyuze Lv , Yuxiang Gao , Hongyu Wu , Zhicheng Zhong

Discovering materials with new structural chemistry is key to achieving transformative functionality. Generative artificial intelligence offers a scalable route to propose candidate crystal structures. We introduce a reliable low-cost proxy…

Prediction of protein structures using computational approaches has been explored for over two decades, paving a way for more focused research and development of algorithms in comparative modelling, ab intio modelling and structure…

Quantitative Methods · Quantitative Biology 2020-05-19 Surbhi Dhingra , Ramanathan Sowdhamini , Frédéric Cadet , Bernard Offmann

Due to the subtle balance of intermolecular interactions that govern structure-property relations, predicting the stability of crystal structures formed from molecular building blocks is a highly non-trivial scientific problem. A…

Chemical Physics · Physics 2022-12-26 Rose K. Cersonsky , Maria Pakhnova , Edgar A. Engel , Michele Ceriotti

Machine learning (ML) is becoming increasingly popular for predicting material properties to accelerate materials discovery. Because material properties are strongly affected by its crystal structure, a key issue is converting the crystal…

Materials Science · Physics 2023-10-12 Hirofumi Tsuruta , Yukari Katsura , Masaya Kumagai

Atomic structure analysis of crystalline materials is a paramount endeavor in both chemical and material sciences. This sophisticated technique necessitates not only a solid foundation in crystallography but also a profound comprehension of…

Machine Learning · Computer Science 2026-04-27 Kaipeng Zheng , Weiran Huang , Wanli Ouyang , Han-Sen Zhong , Yuqiang Li

Nanoporous materials hold promise for diverse sustainable applications, yet their vast chemical space poses challenges for efficient design. Machine learning offers a compelling pathway to accelerate the exploration, but existing models…

Materials Science · Physics 2025-09-24 Zhenhao Zhou , Salman Bin Kashif , Jin-Hu Dou , Chris Wolverton , Kaihang Shi , Tao Deng , Zhenpeng Yao

Historically, materials discovery has been driven by a laborious trial-and-error process. The growth of materials databases and emerging informatics approaches finally offer the opportunity to transform this practice into data- and…

Materials Science · Physics 2017-06-28 Olexandr Isayev , Corey Oses , Cormac Toher , Eric Gossett , Stefano Curtarolo , Alexander Tropsha

Recent advances in machine learning techniques have made it possible to use high-throughput screening to identify novel materials with specific properties. However, the large number of potential candidates produced by these techniques can…

The rapid adoption of machine learning (ML) in domain sciences necessitates best practices and standardized benchmarking for performance evaluation. We present Matbench Discovery, an evaluation framework for ML energy models, applied as…

The identification of materials with exceptional properties is an essential objective to enable technological progress. We propose the application of \textit{Quality-Diversity} algorithms to the field of crystal structure prediction. The…

Materials Science · Physics 2024-03-07 Marta Wolinska , Aron Walsh , Antoine Cully

The main target of retrosynthesis is to recursively decompose desired molecules into available building blocks. Existing template-based retrosynthesis methods follow a template selection stereotype and suffer from limited training…

Chemical Physics · Physics 2022-12-26 Chaochao Yan , Peilin Zhao , Chan Lu , Yang Yu , Junzhou Huang