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Mathematical models can provide quantitative insight into immunoreceptor signaling, but require parameterization and uncertainty quantification before making reliable predictions. We review currently available methods and software tools to…

Quantitative Methods · Quantitative Biology 2019-06-28 Eshan D. Mitra , William S. Hlavacek

Parameter inference and uncertainty quantification are important steps when relating mathematical models to real-world observations, and when estimating uncertainty in model predictions. However, methods for doing this can be…

Quantitative Methods · Quantitative Biology 2025-08-27 Michael J. Plank , Matthew J. Simpson

Statistical inference more often than not involves models which are non-linear in the parameters thus leading to non-Gaussian posteriors. Many computational and analytical tools exist that can deal with non-Gaussian distributions, and…

General Relativity and Quantum Cosmology · Physics 2021-01-20 Eileen Giesel , Robert Reischke , Björn Malte Schäfer , Dominic Chia

In the application of Bayesian methods to metrology, pre-data probabilities play a critical role in the estimation of the model uncertainty. Following the observation that distributions form Riemann's manifolds, methods of differential…

Methodology · Statistics 2015-12-17 Giovanni Mana , Carlo Palmisano

In this dissertation, an abstract formalism extending information geometry is introduced. This framework encompasses a broad range of modelling problems, including possible applications in machine learning and in the information theoretical…

Mathematical Physics · Physics 2015-01-06 Ben Anthonis

Interpreting data with mathematical models is an important aspect of real-world industrial and applied mathematical modeling. Often we are interested to understand the extent to which a particular set of data informs and constrains model…

Methodology · Statistics 2025-03-06 Matthew J Simpson , Ruth E Baker

Research on the use of information geometry (IG) in modern physics has witnessed significant advances recently. In this review article, we report on the utilization of IG methods to define measures of complexity in both classical and,…

Statistical Mechanics · Physics 2018-04-10 D. Felice , C. Cafaro , S. Mancini

Parameter estimation based on uncertain data represented as belief structures is one of the latest problems in the Dempster-Shafer theory. In this paper, a novel method is proposed for the parameter estimation in the case where belief…

Artificial Intelligence · Computer Science 2014-02-18 Xinyang Deng , Yong Hu , Felix Chan , Sankaran Mahadevan , Yong Deng

Using the mathematical framework of information geometry, we introduce a novel method which allows one to efficiently determine the exact shape of simultaneous confidence regions for non-linearly parametrised models. Furthermore, we show…

Methodology · Statistics 2022-11-08 Rafael Arutjunjan , Bjoern Malte Schaefer , Clemens Kreutz

Due to lack of scientific understanding, some mechanisms may be missing in mathematical modeling of complex phenomena in science and engineering. These mathematical models thus contain some uncertainties such as uncertain parameters. One…

Probability · Mathematics 2012-04-05 Jinqiao Duan , Ting Gao , Guowei He

Information geometry is a study of applying differential geometry methods to challenging statistical problems, such as uncertainty quantification. In this work, we use information geometry to study how measurement uncertainties in…

Nuclear Theory · Physics 2025-09-15 M. Imbrišak , A. E. Lovell , M. R. Mumpower

Information geometry is a study of statistical manifolds, that is, spaces of probability distributions from a geometric perspective. Its classical information-theoretic applications relate to statistical concepts such as Fisher information,…

Information Theory · Computer Science 2023-10-09 Kumar Vijay Mishra , M. Ashok Kumar , Ting-Kam Leonard Wong

In this paper, we consider the problem of quantifying parametric uncertainty in classical empirical interatomic potentials (IPs) using both Bayesian (Markov Chain Monte Carlo) and frequentist (profile likelihood) methods. We interface these…

Exploiting the geometric nature of statistical divergences, we devise a way to define associated induced uncertainty measures for discrete and finite probability distributions. We also report new uncertainty measures and discuss their…

Quantum Physics · Physics 2021-06-29 Gautam Sharma , Sk Sazim

In machine learning, accurately predicting the probability that a specific input is correct is crucial for risk management. This process, known as uncertainty (or confidence) estimation, is particularly important in mission-critical…

Machine Learning · Computer Science 2023-01-12 Gabriella Chouraqui , Liron Cohen , Gil Einziger , Liel Leman

Motivated by the presence of deep connections among dynamical equations, experimental data, physical systems, and statistical modeling, we report on a series of findings uncovered by the Authors and collaborators during the last decade…

Data Analysis, Statistics and Probability · Physics 2018-08-22 Sean Alan Ali , Carlo Cafaro , Steven Gassner , Adom Giffin

A crucial step in fitting a regression model to data is determining the model's structure, i.e., the subset of explanatory variables to be included. However, the uncertainty in this step is often overlooked due to a lack of satisfactory…

Methodology · Statistics 2025-11-13 Ryan Martin , Naomi Singer , Jonathan Williams

It is known that statistical model selection as well as identification of dynamical equations from available data are both very challenging tasks. Physical systems behave according to their underlying dynamical equations which, in turn, can…

Mathematical Physics · Physics 2017-10-11 Sean Alan Ali , Carlo Cafaro

Using the generalized entropies which depend on two parameters we propose a set of quantitative characteristics derived from the Information Geometry based on these entropies. Our aim, at this stage, is modest, as we are first constructing…

Mathematical Physics · Physics 2018-02-14 Demetris P. K. Ghikas , Fotios Oikonomou

Wasserstein geometry and information geometry are two important structures introduced in a manifold of probability distributions. The former is defined by using the transportation cost between two distributions, so it reflects the metric…

Statistics Theory · Mathematics 2020-03-13 Shun-ichi Amari
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