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Melanoma brain metastases (MBM) are common and spatially heterogeneous lesions, complicating cohort-level analyses due to anatomical variability and differing MRI protocols. We propose a fully differentiable, deep-learning-based deformable…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Nanna E. Wielenberg , Ilinca Popp , Oliver Blanck , Lucas Zander , Jan C. Peeken , Stephanie E. Combs , Anca-Ligia Grosu , Dimos Baltas , Tobias Fechter

Diffeomorphic image registration is a commonly used method to deform one image to resemble another. While warping a single image to another is useful, it can be advantageous to warp multiple images simultaneously, such as in tracking the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Sean Rendell , Jinming Duan

Clinical decision making from magnetic resonance imaging (MRI) combines complementary information from multiple MRI sequences (defined as 'modalities'). MRI image registration aims to geometrically 'pair' diagnoses from different…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Chengjia Wang , Giorgos Papanastasiou

We propose a registration algorithm for 2D CT/MRI medical images with a new unsupervised end-to-end strategy using convolutional neural networks. The contributions of our algorithm are threefold: (1) We transplant traditional image…

Computer Vision and Pattern Recognition · Computer Science 2018-01-23 Siyuan Shan , Wen Yan , Xiaoqing Guo , Eric I-Chao Chang , Yubo Fan , Yan Xu

Image registration is a critical component in the applications of various medical image analyses. In recent years, there has been a tremendous surge in the development of deep learning (DL)-based medical image registration models. This…

Image and Video Processing · Electrical Eng. & Systems 2022-04-26 Subrato Bharati , M. Rubaiyat Hossain Mondal , Prajoy Podder , V. B. Surya Prasath

Most existing deep learning-based registration methods are trained on single-type images to address same-domain tasks.However, cross-domain deformable registration remains challenging.We argue that the tailor-made matching criteria in…

Computer Vision and Pattern Recognition · Computer Science 2024-06-19 Zhuoyuan Wang , Haiqiao Wang , Yi Wang

Accurately registering breast MR images from different time points enables the alignment of anatomical structures and tracking of tumor progression, supporting more effective breast cancer detection, diagnosis, and treatment planning.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-01 Yaqian Chen , Hanxue Gu , Haoyu Dong , Qihang Li , Yuwen Chen , Nicholas Konz , Lin Li , Maciej A. Mazurowski

Image registration is used in many medical image analysis applications, such as tracking the motion of tissue in cardiac images, where cardiac kinematics can be an indicator of tissue health. Registration is a challenging problem for deep…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Benjamin Graham

Registration of histological and mass spectrometry imaging (MSI) allows for more precise identification of structural changes and chemical interactions in tissue. With histology and MSI having entirely different image formation processes…

Image and Video Processing · Electrical Eng. & Systems 2025-06-09 Kimberley M. Bird , Xujiong Ye , Alan M. Race , James M. Brown

Registration is an essential tool in image analysis. Deep learning based alternatives have recently become popular, achieving competitive performance at a faster speed. However, many contemporary techniques are limited to volumetric…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Balder Croquet , Daan Christiaens , Seth M. Weinberg , Michael Bronstein , Dirk Vandermeulen , Peter Claes

We introduce HyperMorph, a framework that facilitates efficient hyperparameter tuning in learning-based deformable image registration. Classical registration algorithms perform an iterative pair-wise optimization to compute a deformation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Andrew Hoopes , Malte Hoffmann , Douglas N. Greve , Bruce Fischl , John Guttag , Adrian V. Dalca

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

We propose a deformable registration algorithm based on unsupervised learning of a low-dimensional probabilistic parameterization of deformations. We model registration in a probabilistic and generative fashion, by applying a conditional…

Computer Vision and Pattern Recognition · Computer Science 2018-07-23 Julian Krebs , Tommaso Mansi , Boris Mailhé , Nicholas Ayache , Hervé Delingette

Deformable image registration aims to precisely align medical images from different modalities or times. Traditional deep learning methods, while effective, often lack interpretability, real-time observability and adjustment capacity during…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Yongtai Zhuo , Yiqing Shen

Image registration is essential for medical image applications where alignment of voxels across multiple images is needed for qualitative or quantitative analysis. With recent advancements in deep neural networks and parallel computing,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Yi Zhang , Yidong Zhao , Hui Xue , Peter Kellman , Stefan Klein , Qian Tao

Image registration plays an important role in comparing images. It is particularly important in analyzing medical images like CT, MRI, PET, etc. to quantify different biological samples, to monitor disease progression and to fuse different…

Computer Vision and Pattern Recognition · Computer Science 2018-10-22 Abdullah Nazib , Clinton Fookes , Dimitri Perrin

Deep neural networks are increasingly used for pair-wise image registration. We propose to extend current learning-based image registration to allow simultaneous registration of multiple images. To achieve this, we build upon the pair-wise…

Image and Video Processing · Electrical Eng. & Systems 2020-10-02 Tycho F. A. van der Ouderaa , Ivana Išgum , Wouter B. Veldhuis , Bob D. de Vos

Most of the deep learning based medical image registration algorithms focus on brain image registration tasks.Compared with brain registration, the chest CT registration has larger deformation, more complex background and region over-lap.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Cheng Wang , Qiyu Gao , Fandong Zhang , Shu Zhang , Yizhou Yu

Medical image registration is a critical component of clinical imaging workflows, enabling accurate longitudinal assessment, multi-modal data fusion, and image-guided interventions. Intensity-based approaches often struggle with…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Eytan Kats , Mattias P. Heinrich

In this paper, we summarize the methods and experimental results we proposed for Task 2 in the learn2reg 2024 Challenge. This task focuses on unsupervised registration of anatomical structures in brain MRI images between different patients.…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Yuxi Zhang , Xiang Chen , Jiazheng Wang , Min Liu , Yaonan Wang , Dongdong Liu , Renjiu Hu , Hang Zhang