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Biomedical knowledge graphs permit an integrative computational approach to reasoning about biological systems. The nature of biological data leads to a graph structure that differs from those typically encountered in benchmarking datasets.…

Machine Learning · Computer Science 2021-03-19 Yushan Liu , Marcel Hildebrandt , Mitchell Joblin , Martin Ringsquandl , Rime Raissouni , Volker Tresp

The graph structure of biomedical data differs from those in typical knowledge graph benchmark tasks. A particular property of biomedical data is the presence of long-range dependencies, which can be captured by patterns described as…

Machine Learning · Computer Science 2020-07-13 Yushan Liu , Marcel Hildebrandt , Mitchell Joblin , Martin Ringsquandl , Volker Tresp

Recent work on recommender systems has considered external knowledge graphs as valuable sources of information, not only to produce better recommendations but also to provide explanations of why the recommended items were chosen. Pure…

Information Retrieval · Computer Science 2020-07-28 Yikun Xian , Zuohui Fu , Qiaoying Huang , S. Muthukrishnan , Yongfeng Zhang

Recent advances in personalized recommendation have sparked great interest in the exploitation of rich structured information provided by knowledge graphs. Unlike most existing approaches that only focus on leveraging knowledge graphs for…

Information Retrieval · Computer Science 2019-06-13 Yikun Xian , Zuohui Fu , S. Muthukrishnan , Gerard de Melo , Yongfeng Zhang

Discovering new medicines is the hallmark of human endeavor to live a better and longer life. Yet the pace of discovery has slowed down as we need to venture into more wildly unexplored biomedical space to find one that matches today's high…

Artificial Intelligence · Computer Science 2022-02-16 Tri Minh Nguyen , Thin Nguyen , Truyen Tran

Neurosymbolic AI is an increasingly active area of research that combines symbolic reasoning methods with deep learning to leverage their complementary benefits. As knowledge graphs are becoming a popular way to represent heterogeneous and…

Artificial Intelligence · Computer Science 2025-01-13 Lauren Nicole DeLong , Ramon Fernández Mir , Jacques D. Fleuriot

Knowledge graph reasoning is the fundamental component to support machine learning applications such as information extraction, information retrieval, and recommendation. Since knowledge graphs can be viewed as the discrete symbolic…

Artificial Intelligence · Computer Science 2021-04-01 Jing Zhang , Bo Chen , Lingxi Zhang , Xirui Ke , Haipeng Ding

Knowledge graphs are powerful tools for representing and organising complex biomedical data. Several knowledge graph embedding algorithms have been proposed to learn from and complete knowledge graphs. However, a recent study demonstrates…

Biomedical datasets are often modeled as knowledge graphs (KGs) because they capture the multi-relational, heterogeneous, and dynamic natures of biomedical systems. KG completion (KGC), can, therefore, help researchers make predictions to…

Artificial Intelligence · Computer Science 2023-07-18 Lauren Nicole DeLong , Ramon Fernández Mir , Zonglin Ji , Fiona Niamh Coulter Smith , Jacques D. Fleuriot

Knowledge graphs (KGs) are powerful tools for modelling complex, multi-relational data and supporting hypothesis generation, particularly in applications like drug repurposing. However, for predictive methods to gain acceptance as credible…

Artificial Intelligence · Computer Science 2026-02-06 Susana Nunes , Samy Badreddine , Catia Pesquita

There has been growing attention on fairness considerations recently, especially in the context of intelligent decision making systems. Explainable recommendation systems, in particular, may suffer from both explanation bias and performance…

Information Retrieval · Computer Science 2020-06-30 Zuohui Fu , Yikun Xian , Ruoyuan Gao , Jieyu Zhao , Qiaoying Huang , Yingqiang Ge , Shuyuan Xu , Shijie Geng , Chirag Shah , Yongfeng Zhang , Gerard de Melo

Motivation: Biological data and knowledge bases increasingly rely on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. In the past years, feature learning methods that are…

Quantitative Methods · Quantitative Biology 2017-05-01 Mona Alshahrani , Mohammed Asif Khan , Omar Maddouri , Akira R Kinjo , Núria Queralt-Rosinach , Robert Hoehndorf

Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases.…

Artificial Intelligence · Computer Science 2022-04-29 Niclas Heilig , Jan Kirchhoff , Florian Stumpe , Joan Plepi , Lucie Flek , Heiko Paulheim

Neurosymbolic artificial intelligence is a growing field of research aiming to combine neural network learning capabilities with the reasoning abilities of symbolic systems. Informed multi-label classification is a sub-field of…

Artificial Intelligence · Computer Science 2025-01-24 Arthur Ledaguenel , Céline Hudelot , Mostepha Khouadjia

Recommender Systems have been widely used to help users in finding what they are looking for thus tackling the information overload problem. After several years of research and industrial findings looking after better algorithms to improve…

Information Retrieval · Computer Science 2018-07-18 Vito Bellini , Angelo Schiavone , Tommaso Di Noia , Azzurra Ragone , Eugenio Di Sciascio

Recent years have witnessed a rapid growth of recommender systems, providing suggestions in numerous applications with potentially high social impact, such as health or justice. Meanwhile, in Europe, the upcoming AI Act mentions…

Artificial Intelligence · Computer Science 2024-07-18 Simon Delarue , Astrid Bertrand , Tiphaine Viard

Large language models have achieved near-expert performance in structured reasoning domains like mathematics and programming, yet their ability to perform compositional multi-hop reasoning in specialized scientific fields remains limited.…

Artificial Intelligence · Computer Science 2026-03-09 Yuval Kansal , Niraj K. Jha

We introduced a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational…

Quantitative Methods · Quantitative Biology 2014-06-17 Ruggero Gramatica , T. Di Matteo , Stefano Giorgetti , Massimo Barbiani , Dorian Bevec , Tomaso Aste

Drug repurposing is more relevant than ever due to drug development's rising costs and the need to respond to emerging diseases quickly. Knowledge graph embedding enables drug repurposing using heterogeneous data sources combined with…

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

Computation and Language · Computer Science 2023-04-05 Maolin Luo , Xiang Zhang
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