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Cerebral aneurysms are pathological dilations of intracranial arteries that can rupture with devastating consequences, including subarachnoid hemorrhage, stroke, and death. Accumulating evidence indicates that local hemodynamic forces play…
Knowledge of the mechanical properties of the aorta is essential as important concerns regarding the treatment of aortic pathologies, such as atherosclerosis, aneurysms and dissections, are fundamentally mechanobiological. A comprehensive…
Abdominal aortic aneurysms (AAA) pose a significant clinical risk due to their potential for rupture, which is often asymptomatic but can be fatal. Although maximum diameter is commonly used for risk assessment, diameter alone is…
Intrasaccular flow disruptors treat cerebral aneurysms by diverting the blood flow from the aneurysm sac. Residual flow into the sac after the intervention is a failure that could be due to the use of an undersized device, or to vascular…
Diverse processes rely on the viscous flow of polymer solutions through porous media. In many cases, the macroscopic flow resistance abruptly increases above a threshold flow rate in a porous medium---but not in bulk solution. The reason…
Thoracic aortic aneurysms (TAAs) arise from diverse mechanical and mechanobiological disruptions to the aortic wall that increase the risk of dissection or rupture. Evidence links TAA development to dysfunctions in the aortic…
In impermeable media, a hydraulic fracture can continue to expand even without additional fluid injection if its volume exceeds the limiting volume of a hydrostatically loaded radial fracture. This limit depends on the mechanical properties…
Abdominal aortic aneurysms (AAAs) are progressive focal dilatations of the abdominal aorta. AAAs may rupture, with a survival rate of only 20\%. Current clinical guidelines recommend elective surgical repair when the maximum AAA diameter…
An abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that, if not treated, tends to grow and may rupture. A significant unmet need in the assessment of AAA disease, for the diagnosis, prognosis and follow-up, is the…
Amorphous solids lack long-range order. Therefore identifying structural defects -- akin to dislocations in crystalline solids -- that carry plastic flow in these systems remains a daunting challenge. By comparing many different structural…
We investigate the linear instability of flows that are stable according to Rayleigh's criterion for rotating fluids. Using Taylor-Couette flow as a primary test case, we develop large Reynolds number matched asymptotic expansion theories.…
Mechanical heart valve replacement is the preferred alternative in younger patients with severe symptomatic aortic valve disease. However, thrombus and pannus formations are common complications associated with bileaflet mechanical heart…
Viscoelastic fluids exhibit elastic instabilities in simple shear flow and flow through curved streamlines. Surprisingly, we found in a porous medium such fluids show strikingly different hydrodynamic instabilities depicted by very large…
Arterial aneurysm (Fig.1) is a bulb-shape local expansion of human arteries, the rupture of which is a leading cause of morbidity and mortality in US. Therefore, the prediction of arterial aneurysm rupture is of great significance for…
Abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is typically an asymptomatic condition that if left untreated can expand to the point of rupture. Mechanically-speaking, rupture…
We present an original approach for predicting the static recrystallization texture development during annealing of deformed crystalline materials. The microstructure is considered as a population of subgrains and grains whose sizes and…
Microscale turbulent flow in porous media is conducive to the development of flow instabilities due to strong vortical and shearing flow occurring within the pore space. When the flow instabilities around individual solid obstacles interact…
The rupture of an abdominal aortic aneurysm (AAA) is associated with a high mortality. When an AAA ruptures, 50% of the patients die before reaching the hospital. Of the patients that are able to reach the operating room, only 50% have it…
Experiments have shown that flow in compliant microchannels can become unstable at a much lower Reynolds number than the corresponding flow in a rigid conduit. Therefore, it has been suggested that the wall's elastic compliance can be…
A search in Scopus within "Article title, Abstract, Keywords" unveils 2,444 documents focused on the biomechanics of Abdominal Aortic Aneurysm (AAA), mostly on AAA wall stress. Only 24 documents investigated AAA kinematics, an important…