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Background: In settings where proof-of-principle trials have succeeded but the effectiveness of different forms of implementation remains uncertain, trials that not only generate information about intervention effects but also provide…

Quantitative Methods · Quantitative Biology 2017-05-16 Guy Harling , Rui Wang , Jukka-Pekka Onnela , Victor De Gruttola

Health-related data is noisy and stochastic in implying the true physiological states of patients, limiting information contained in single-moment observations for sequential clinical decision making. We model patient-clinician interactions…

Artificial Intelligence · Computer Science 2019-05-21 Luchen Li , Matthieu Komorowski , Aldo A. Faisal

In healthcare, there is much interest in estimating policies, or mappings from covariates to treatment decisions. Recently, there is also interest in constraining these estimated policies to the standard of care, which generated the…

Methodology · Statistics 2026-02-17 Samuel J. Weisenthal , Sally W. Thurston , Ashkan Ertefaie

Causal effect estimation in networked systems is central to data-driven decision making. In such settings, interventions on one unit can spill over to others, and in complex physical or social systems, the interaction pathways driving these…

Machine Learning · Statistics 2025-11-27 Sadegh Shirani , Mohsen Bayati

Motivated by COVID-19 vaccine allocation, where vulnerable subpopulations are simultaneously more impacted in terms of health and more disadvantaged in terms of access to the vaccine, we formalize and study the problem of resource…

Artificial Intelligence · Computer Science 2024-02-02 Kenya Andrews , Mesrob Ohannessian , Tanya Berger-Wolf

We analyze an optimal control version of a simple SIRS epidemiology model. The policy maker can adopt policies to diminish the contact rate between infected and susceptible individuals, at a specific economic cost. The arrival of a vaccine…

Populations and Evolution · Quantitative Biology 2020-06-09 Evangelos Magirou

Cluster randomization trials commonly employ multiple endpoints. When a single summary of treatment effects across endpoints is of primary interest, global hypothesis testing/effect estimation methods represent a common analysis strategy.…

Methodology · Statistics 2025-05-19 E. Davies Smith , V. Jairath , G. Zou

Pre-exposure prophylaxis (PrEP) is an effective intervention for preventing HIV transmission, but high cost and uneven uptake raise challenges for resource allocation. While spillover effects, wherein PrEP use in one group reduces…

Dynamical Systems · Mathematics 2026-02-06 Chiara Piazzola , Salman Safdar , Alex Viguerie , Abba B. Gumel

The distribution of treatment effects (DTE) is often of interest in the context of welfare policy evaluation. In this paper, I consider partial identification of the DTE under known marginal distributions and support restrictions on the…

Methodology · Statistics 2014-10-23 Ju Hyun Kim

Allocating scarce resources among agents to maximize global utility is, in general, computationally challenging. We focus on problems where resources enable agents to execute actions in stochastic environments, modeled as Markov decision…

Multiagent Systems · Computer Science 2011-10-13 D. A. Dolgov , E. H. Durfee

Using only retrospective data, we study the problem of predicting treatment effects for the same treatment/policy implemented in a different location or time period. We propose a distributionally robust estimator that minimizes the…

Econometrics · Economics 2026-04-29 Ruonan Xu , Xiye Yang

Efficient contact tracing and isolation is an effective strategy to control epidemics. It was used effectively during the Ebola epidemic and successfully implemented in several parts of the world during the ongoing COVID-19 pandemic. An…

Computers and Society · Computer Science 2022-01-17 George Li , Arash Haddadan , Ann Li , Madhav Marathe , Aravind Srinivasan , Anil Vullikanti , Zeyu Zhao

Evidence from observational studies has become increasingly important for supporting healthcare policy making via cost-effectiveness (CE) analyses. Similar as in comparative effectiveness studies, health economic evaluations that consider…

Randomized experiments on social networks pose statistical challenges, due to the possibility of interference between units. We propose new methods for estimating attributable treatment effects in such settings. The methods do not require…

Methodology · Statistics 2015-10-13 David S. Choi

We aim to design a fairness-aware allocation approach to maximize the geographical diversity and avoid unfairness in the sense of demographic disparity. During the development of this work, the COVID-19 pandemic is still spreading in the…

Optimization and Control · Mathematics 2026-05-12 Hadis Anahideh , Lulu Kang , Nazanin Nezami

In this paper, we introduce an algorithm designed to solve a Multilevel MOnoObjective Linear Programming Problem (ML(MO)OLPP). Our approach is a refined adaptation of Sinha and Sinha's linear programming method, incorporating the…

Optimization and Control · Mathematics 2025-03-17 Mustapha Kaci

Metapopulation epidemic models describe epidemic dynamics in networks of spatially distant patches connected with pathways for migration of individuals. In the present study, we deal with a susceptible-infected-recovered (SIR)…

Physics and Society · Physics 2019-08-22 Akari Matsuki , Gouhei Tanaka

In auction and matching markets, estimating the welfare effects of demand-side treatments is challenging because of spillovers through the mechanism. We develop a quasi-experimental approach that avoids parametric assumptions typically…

Econometrics · Economics 2026-03-03 Evan Munro

This paper provides partial identification results for the marginal treatment effect ($MTE$) when the binary treatment variable is potentially misreported and the instrumental variable is discrete. Identification results are derived under…

Econometrics · Economics 2023-04-04 Santiago Acerenza

Most methods in reinforcement learning use a Policy Gradient (PG) approach to learn a parametric stochastic policy that maps states to actions. The standard approach is to implement such a mapping via a neural network (NN) whose parameters…

Machine Learning · Computer Science 2024-05-29 Sergio Rozada , Antonio G. Marques