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Virtual screening aims to efficiently identify active ligands from massive chemical libraries for a given target pocket. Recent CLIP-style models such as DrugCLIP enable scalable virtual screening by embedding pockets and ligands into a…

Machine Learning · Computer Science 2026-02-18 Anjie Qiao , Zhen Wang , Yaliang Li , Jiahua Rao , Yuedong Yang

The clinical adoption of artificial intelligence (AI) in medical imaging requires models that are both diagnostically accurate and interpretable to clinicians. While current multimodal biomedical foundation models prioritize performance,…

Adopting contrastive image-text pretrained models like CLIP towards video classification has gained attention due to its cost-effectiveness and competitive performance. However, recent works in this area face a trade-off. Finetuning the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Syed Talal Wasim , Muzammal Naseer , Salman Khan , Fahad Shahbaz Khan , Mubarak Shah

We examine the effects of contrastive visual semantic pretraining by comparing the geometry and semantic properties of contextualized English language representations formed by GPT-2 and CLIP, a zero-shot multimodal image classifier which…

Computation and Language · Computer Science 2022-03-16 Robert Wolfe , Aylin Caliskan

Numerous methods have been proposed to adapt a pre-trained foundational CLIP model for few-shot classification. As CLIP is trained on a large corpus, it generalises well through adaptation to few-shot classification. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2024-09-18 Alexey Kravets , Vinay Namboodiri

Probes are small networks that predict properties of underlying data from embeddings, and they provide a targeted, effective way to illuminate the information contained in embeddings. While analysis through the use of probes has become…

Vision-language models such as CLIP have shown great impact on diverse downstream tasks for zero-shot or label-free predictions. However, when it comes to low-level vision such as image restoration their performance deteriorates…

Computer Vision and Pattern Recognition · Computer Science 2024-02-29 Ziwei Luo , Fredrik K. Gustafsson , Zheng Zhao , Jens Sjölund , Thomas B. Schön

While Contrastive Language-Image Pretraining (CLIP) excels at zero-shot tasks by aligning image and text embeddings, its performance in few-shot classification is hindered by a critical limitation: intra-modal misalignment. This issue,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Christoph Timmermann , Hyunse Lee , Woojin Lee

Weakly supervised semantic segmentation (WSSS) with image-level labels is a challenging task. Mainstream approaches follow a multi-stage framework and suffer from high training costs. In this paper, we explore the potential of Contrastive…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yuqi Lin , Minghao Chen , Wenxiao Wang , Boxi Wu , Ke Li , Binbin Lin , Haifeng Liu , Xiaofei He

Existing semantic segmentation approaches are often limited by costly pixel-wise annotations and predefined classes. In this work, we present CLIP-S$^4$ that leverages self-supervised pixel representation learning and vision-language models…

Computer Vision and Pattern Recognition · Computer Science 2023-05-03 Wenbin He , Suphanut Jamonnak , Liang Gou , Liu Ren

Contrastive Language-Image Pre-Training (CLIP) is highly instrumental in machine learning applications within a large variety of domains. We investigate the geometry of this embedding, which is still not well understood. We examine the raw…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Meir Yossef Levi , Guy Gilboa

Multimodal fusion breaks through the boundaries between diverse modalities and has already achieved notable performances. However, in many specialized fields, it is struggling to obtain sufficient alignment data for training, which…

Machine Learning · Computer Science 2024-09-24 Zijia Song , Zelin Zang , Yelin Wang , Guozheng Yang , Kaicheng yu , Wanyu Chen , Miaoyu Wang , Stan Z. Li

Vision-language models such as CLIP have boosted the performance of open-vocabulary object detection, where the detector is trained on base categories but required to detect novel categories. Existing methods leverage CLIP's strong…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Cheng Shi , Sibei Yang

As a general-purpose vision-language pretraining model, CLIP demonstrates strong generalization ability in image-text alignment tasks and has been widely adopted in downstream applications such as image classification and image-text…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Kuanrong Liu , Siyuan Liang , Cheng Qian , Ming Zhang , Xiaochun Cao

Recent studies have shown that CLIP model's adversarial robustness in zero-shot classification tasks can be enhanced by adversarially fine-tuning its image encoder with adversarial examples (AEs), which are generated by minimizing the…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Jiacheng Zhang , Jinhao Li , Hanxun Huang , Sarah M. Erfani , Benjamin I. P. Rubinstein , Feng Liu

Pre-trained vision-language models, e.g., CLIP, have been successfully applied to zero-shot semantic segmentation. Existing CLIP-based approaches primarily utilize visual features from the last layer to align with text embeddings, while…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Yunheng Li , ZhongYu Li , Quansheng Zeng , Qibin Hou , Ming-Ming Cheng

Large-scale Pre-Training Vision-Language Model such as CLIP has demonstrated outstanding performance in zero-shot classification, e.g. achieving 76.3% top-1 accuracy on ImageNet without seeing any example, which leads to potential benefits…

Computer Vision and Pattern Recognition · Computer Science 2023-12-15 Xuefeng Hu , Ke Zhang , Lu Xia , Albert Chen , Jiajia Luo , Yuyin Sun , Ken Wang , Nan Qiao , Xiao Zeng , Min Sun , Cheng-Hao Kuo , Ram Nevatia

This paper presents a novel training-free framework for open-vocabulary image segmentation and object recognition (OVSR), which leverages EfficientNetB0, a convolutional neural network, for unsupervised segmentation and CLIP, a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Ying Dai , Wei Yu Chen

While large language-image pre-trained models like CLIP offer powerful generic features for image clustering, existing methods typically freeze the encoder. This creates a fundamental mismatch between the model's task-agnostic…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Zihan Li , Wei Sun , Jing Hu , Jianhua Yin , Jianlong Wu , Liqiang Nie

This paper introduces a powerful encoder that transfers CLIP`s capabilities to event-based data, enhancing its utility and expanding its applicability across diverse domains. While large-scale datasets have significantly advanced…

Computer Vision and Pattern Recognition · Computer Science 2025-05-09 Sungheon Jeong , Hanning Chen , Sanggeon Yun , Suhyeon Cho , Wenjun Huang , Xiangjian Liu , Mohsen Imani