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A common problem in machine learning is determining if a variable significantly contributes to a model's prediction performance. This problem is aggravated for datasets, such as gene expression datasets, that suffer the worst case of…

Methodology · Statistics 2023-10-13 Yue Wu , Ted Spaide , Kenji Nakamichi , Russell Van Gelder , Aaron Lee

High-dimensional measurements are often correlated which motivates their approximation by factor models. This holds also true when features are engineered via low-dimensional interactions or kernel tricks. This often results in over…

Applications · Statistics 2025-09-03 Xiaonan Zhu , Bingyan Wang , Jianqing Fan

The majority of existing post-hoc explanation approaches for machine learning models produce independent, per-variable feature attribution scores, ignoring a critical inherent characteristics of homogeneously structured data, such as visual…

Machine Learning · Computer Science 2023-02-14 Vadim Borisov , Gjergji Kasneci

Multiple sequence alignment (MSA) data play a crucial role in the study of protein mutations, with contact prediction being a notable application. Existing methods are often model-based or algorithmic and typically do not incorporate…

Methodology · Statistics 2026-01-23 Fan Yang , Zhao Ren , Wen Zhou , Kejue Jia , Robert Jernigan

Explainable artificial intelligence promises to yield insights into relevant features, thereby enabling humans to examine and scrutinize machine learning models or even facilitating scientific discovery. Considering the widespread technique…

Machine Learning · Computer Science 2026-03-30 Jörg Martin , Stefan Haufe

Clinical machine learning applications are often plagued with confounders that are clinically irrelevant, but can still artificially boost the predictive performance of the algorithms. Confounding is especially problematic in mobile health…

Applications · Statistics 2018-11-29 Elias Chaibub Neto

We consider the following multi-component sparse PCA problem: given a set of data points, we seek to extract a small number of sparse components with disjoint supports that jointly capture the maximum possible variance. These components can…

Machine learning transparency calls for interpretable explanations of how inputs relate to predictions. Feature attribution is a way to analyze the impact of features on predictions. Feature interactions are the contextual dependence…

Machine Learning · Statistics 2020-06-22 Michael Tsang , Sirisha Rambhatla , Yan Liu

This paper presents an automated approach for interpretable feature recommendation for solving signal data analytics problems. The method has been tested by performing experiments on datasets in the domain of prognostics where…

Machine Learning · Statistics 2017-11-07 Snehasis Banerjee , Tanushyam Chattopadhyay , Ayan Mukherjee

Principal component analysis (PCA) is a widespread technique for data analysis that relies on the covariance-correlation matrix of the analyzed data. However to properly work with high-dimensional data, PCA poses severe mathematical…

Quantitative Methods · Quantitative Biology 2018-10-18 Luigi Leonardo Palese

SHAP is a popular method for measuring variable importance in machine learning models. In this paper, we study the algorithm used to estimate SHAP scores and outline its connection to the functional ANOVA decomposition. We use this…

Methodology · Statistics 2022-11-14 Andrew Herren , P. Richard Hahn

Interpretable machine learning has become a very active area of research due to the rising popularity of machine learning algorithms and their inherently challenging interpretability. Most work in this area has been focused on the…

Machine Learning · Statistics 2023-11-09 Quay Au , Julia Herbinger , Clemens Stachl , Bernd Bischl , Giuseppe Casalicchio

Interpretability is an important area of research for safe deployment of machine learning systems. One particular type of interpretability method attributes model decisions to input features. Despite active development, quantitative…

Machine Learning · Computer Science 2019-11-06 Mengjiao Yang , Been Kim

Recognising and locating image patches or sets of image features is an important task underlying much work in computer vision. Traditionally this has been accomplished using template matching. However, template matching is notoriously…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 M. W. Spratling

Feature selection has been proven a powerful preprocessing step for high-dimensional data analysis. However, most state-of-the-art methods tend to overlook the structural correlation information between pairwise samples, which may…

Machine Learning · Computer Science 2019-07-02 Lu Bai , Lixin Cui , Yue Wang , Philip S. Yu , Edwin R. Hancock

Interpretability studies often involve tracing the flow of information through machine learning models to identify specific model components that perform relevant computations for tasks of interest. Prior work quantifies the importance of a…

Machine Learning · Computer Science 2024-09-17 Maximilian Li , Lucas Janson

It is common to conduct causal inference in matched observational studies by proceeding as though treatment assignments within matched sets are assigned uniformly at random and using this distribution as the basis for inference. This…

Methodology · Statistics 2023-11-14 Samuel D. Pimentel , Yaxuan Huang

The rapid advancement and widespread adoption of machine learning-driven technologies have underscored the practical and ethical need for creating interpretable artificial intelligence systems. Feature importance, a method that assigns…

Machine Learning · Computer Science 2023-12-07 Nimrod Harel , Uri Obolski , Ran Gilad-Bachrach

This paper proposes sparse and easy-to-interpret proximate factors to approximate statistical latent factors. Latent factors in a large-dimensional factor model can be estimated by principal component analysis (PCA), but are usually hard to…

Methodology · Statistics 2020-08-04 Markus Pelger , Ruoxuan Xiong

Permutation tests are among the simplest and most widely used statistical tools. Their p-values can be computed by a straightforward sampling of permutations. However, this way of computing p-values is often so slow that it is replaced by…

Computation · Statistics 2018-07-27 Jean-Marie Droz