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Predictive modeling with electronic health record (EHR) data is anticipated to drive personalized medicine and improve healthcare quality. Constructing predictive statistical models typically requires extraction of curated predictor…

Named entity disambiguation (NED), which involves mapping textual mentions to structured entities, is particularly challenging in the medical domain due to the presence of rare entities. Existing approaches are limited by the presence of…

Computation and Language · Computer Science 2021-10-18 Maya Varma , Laurel Orr , Sen Wu , Megan Leszczynski , Xiao Ling , Christopher Ré

Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative…

Machine Learning · Statistics 2019-02-12 Zihao Zhu , Changchang Yin , Buyue Qian , Yu Cheng , Jishang Wei , Fei Wang

Heterogeneous information networks (HINs) are ubiquitous in real-world applications. Due to the heterogeneity in HINs, the typed edges may not fully align with each other. In order to capture the semantic subtlety, we propose the concept of…

Social and Information Networks · Computer Science 2018-03-07 Yu Shi , Huan Gui , Qi Zhu , Lance Kaplan , Jiawei Han

Despite extensive standardization, diagnostic interviews for mental health disorders encompass substantial subjective judgment. Previous studies have demonstrated that EEG-based neural measures can function as reliable objective correlates…

Machine Learning · Computer Science 2020-11-19 Garrett Honke , Irina Higgins , Nina Thigpen , Vladimir Miskovic , Katie Link , Sunny Duan , Pramod Gupta , Julia Klawohn , Greg Hajcak

Electronic Health Records (EHR) offer rich real-world data for personalized medicine, providing insights into disease progression, treatment responses, and patient outcomes. However, their sparsity, heterogeneity, and high dimensionality…

Methodology · Statistics 2025-05-28 Linshanshan Wang , Mengyan Li , Zongqi Xia , Molei Liu , Tianxi Cai

Multimodal representation learning has demonstrated remarkable potential in enabling models to process and integrate diverse data modalities, such as text and images, for improved understanding and performance. While the medical domain can…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Shuvendu Roy , Franklin Ogidi , Ali Etemad , Elham Dolatabadi , Arash Afkanpour

In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine,…

Machine Learning · Computer Science 2026-05-05 Hongxi Mao , Wei Zhou , Mengting Jia , Tao Fang , Huan Gao , Bin Zhang , Shangyang Li

Case-based Reasoning (CBR) on high-dimensional and heterogeneous data is a trending yet challenging and computationally expensive task in the real world. A promising approach is to obtain low-dimensional hash codes representing cases and…

Information Retrieval · Computer Science 2022-06-30 Qi Zhang , Liang Hu , Chongyang Shi , Ke Liu , Longbing Cao

Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its…

Computation and Language · Computer Science 2019-06-05 Bonggun Shin , Julien Hogan , Andrew B. Adams , Raymond J. Lynch , Rachel E. Patzer , Jinho D. Choi

Multimodal Large Language Models (MLLMs) have shown transformative potential in medical applications, yet their performance is hindered by conventional data curation strategies that rely on coarse-grained partitioning by modality or…

Computation and Language · Computer Science 2026-04-29 Jianghang Lin , Haihua Yang , Deli Yu , Kai Wu , Kai Ye , Jinghao Lin , Zihan Wang , Yuhang Wu , Liujuan Cao

Fully Homomorphic Encryption (FHE) allows for computation directly on encrypted data and enables privacy-preserving neural inference in the cloud. Prior work has focused on models with dense inputs (e.g., CNNs), with less attention given to…

Cryptography and Security · Computer Science 2026-02-23 Karthik Garimella , Austin Ebel , Gabrielle De Micheli , Brandon Reagen

Medication recommendation is a crucial task for assisting physicians in making timely decisions from longitudinal patient medical records. However, real-world EHR data present significant challenges due to the presence of rarely observed…

Artificial Intelligence · Computer Science 2025-08-15 Yan Ting Chok , Soyon Park , Seungheun Baek , Hajung Kim , Junhyun Lee , Jaewoo Kang

The wide implementation of electronic health record (EHR) systems facilitates the collection of large-scale health data from real clinical settings. Despite the significant increase in adoption of EHR systems, this data remains largely…

Quantitative Methods · Quantitative Biology 2018-10-26 Jinghe Zhang , Kamran Kowsari , James H. Harrison , Jennifer M. Lobo , Laura E. Barnes

Electronic Health Records (EHR) contain valuable clinical information for predicting patient outcomes and guiding healthcare decisions. However, effectively modeling Electronic Health Records (EHRs) requires addressing data heterogeneity…

Machine Learning · Computer Science 2025-07-22 Junhan Yu , Zhunyi Feng , Junwei Lu , Tianxi Cai , Doudou Zhou

Electronic health records (EHRs) are invaluable for clinical research, yet privacy concerns severely restrict data sharing. Synthetic data generation offers a promising solution, but EHRs present unique challenges: they contain both…

Machine Learning · Computer Science 2026-03-26 Shaonan Liu , Yuichiro Iwashita , Soichiro Nakako , Masakazu Iwamura , Koichi Kise

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

Machine Learning · Computer Science 2021-03-29 Weicheng Zhu , Narges Razavian

Recently, deep clustering methods have gained momentum because of the high representational power of deep neural networks (DNNs) such as autoencoder. The key idea is that representation learning and clustering can reinforce each other: Good…

Machine Learning · Computer Science 2021-10-01 Wengang Guo , Kaiyan Lin , Wei Ye

Deep learning-based predictive models, leveraging Electronic Health Records (EHR), are receiving increasing attention in healthcare. An effective representation of a patient's EHR should hierarchically encompass both the temporal…

Machine Learning · Computer Science 2024-05-08 Jiayuan Chen , Changchang Yin , Yuanlong Wang , Ping Zhang