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The notion of testing for equivalence of two treatments is widely used in clinical trials, pharmaceutical experiments,bioequivalence and quality control. It is essentially approached within the intersection-union (IU) principle. According…

Applications · Statistics 2018-02-07 R. Arboretti , E. Carrozzo , F. Pesarin , L. Salmaso

Simultaneous tests of superiority and non-inferiority hypotheses on multiple endpoints are often performed in clinical trials to demonstrate that a new treatment is superior over a control on at least one endpoint and non-inferior on the…

Methodology · Statistics 2023-10-02 Wenfeng Chen , Naiqing Zhao , Guoyou Qin , Jie Chen

Today, generalized linear mixed models are broadly used in many fields. However, the development of tools for performing simultaneous inference has been largely neglected in this domain. A framework for joint inference is indispensable to…

Applications · Statistics 2021-07-12 Katarzyna Reluga , María-José Lombardía , Stefan Sperlich

Over the past decades, linear mixed models have attracted considerable attention in various fields of applied statistics. They are popular whenever clustered, hierarchical or longitudinal data are investigated. Nonetheless, statistical…

Methodology · Statistics 2021-09-20 Katarzyna Reluga , María José Lombardía , Stefan Andreas Sperlich

This paper proposes a novel test for simultaneous jumps in a bivariate It\^o semimartingale when observation times are asynchronous and irregular. Inference is built on a realized correlation coefficient for the jumps of the two processes…

Statistics Theory · Mathematics 2016-06-24 Ole Martin , Mathias Vetter

The analysis of low dimensional factorial designs with possible interactions is a relevant issue. Instead of the common pre-tests for interaction, a simultaneous inference procedure of the primary factor at the respective level of the…

Methodology · Statistics 2022-04-19 Ludwig A. Hothorn

To identify statistically significant conclusions, it is proposed to simultaneously test hypotheses and alternatives. It is shown that, under the condition of free combination of hypotheses and alternatives, the closure method leads to…

Methodology · Statistics 2025-09-15 P. A. Koldanov , A. P. Koldanov

We develop conservative tests for the mean of a bounded population under stratified sampling and apply them to risk-limiting post-election audits. The tests are ``anytime valid'' under sequential sampling, allowing optional stopping in each…

Methodology · Statistics 2026-03-17 Jacob V. Spertus , Mayuri Sridhar , Philip B. Stark

Testing intersections of null-hypotheses is an integral part of closed testing procedures for assessing multiple null-hypotheses under family-wise type 1 error control. Popular intersection tests such as the minimum p-value test are based…

Methodology · Statistics 2025-11-11 Christian Bressen Pipper , Andreas Nordland , Klaus Kähler Holst

The problem of simultaneously testing the marginal distributions of sequentially monitored, independent data streams is considered. The decisions for the various testing problems can be made at different times, using data from all streams,…

Methodology · Statistics 2023-04-21 Yiming Xing , Georgios Fellouris

Simultaneous inference allows for the exploration of data while deciding on criteria for proclaiming discoveries. It was recently proved that all admissible post-hoc inference methods for true discoveries must employ closed testing. In this…

Statistics Theory · Mathematics 2022-03-24 Jinjin Tian , Xu Chen , Eugene Katsevich , Jelle Goeman , Aaditya Ramdas

Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow…

Applications · Statistics 2008-12-18 Bradley Efron

Selective inference is the problem of giving valid answers to statistical questions chosen in a data-driven manner. A standard solution to selective inference is simultaneous inference, which delivers valid answers to the set of all…

Methodology · Statistics 2024-05-03 Tijana Zrnic , William Fithian

The difference-in-differences (DID) research design is a key identification strategy which allows researchers to estimate causal effects under the parallel trends assumption. While the parallel trends assumption is counterfactual and cannot…

Methodology · Statistics 2026-05-12 Jonas M. Mikhaeil , Christopher Harshaw

Uniform interpolation is a strengthening of interpolation that holds for certain propositional logics. The starting point of this chapter is a theorem of A. Pitts, which shows that uniform interpolation holds for intuitionistic…

Logic · Mathematics 2026-02-11 Sam van Gool

We analyze the problem of comparing unitary transformations. The task is to decide, with minimal resources and maximal reliability, whether two given unitary transformations are identical or different. It is possible to make such…

Quantum Physics · Physics 2009-11-07 Erika Andersson , Igor Jex , Stephen M. Barnett

Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies…

Methodology · Statistics 2021-07-14 Hisashi Noma , Kengo Nagashima , Toshi A. Furukawa

We believe that we can exploit the benefits of combinatorial interaction testing (CIT) on many "non-traditional" combinatorial spaces using many "non-traditional" coverage criteria. However, this requires truly flexible CIT approaches. To…

Software Engineering · Computer Science 2016-02-23 Hanefi Mercan , Cemal Yilmaz

In reliability-based design, the estimation of the failure probability is a crucial objective. However, focusing only on the occurrence of the failure event may be insufficient to entirely characterize the reliability of the considered…

Statistics Theory · Mathematics 2020-10-08 Pierre Derennes , Jerome Morio , Florian Simatos

Under the null hypothesis, the marginal probability of the positive response is symmetric at any specified correlated coefficient, and the discordance probability is also symmetric to the positive response probability. The marginal…

Methodology · Statistics 2022-11-11 Guanghui Huang
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