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Recent rapid increase in the generation of clinical data and rapid development of computational science make us able to extract new insights from massive datasets in healthcare industry. Oncological clinical notes are creating rich…

Artificial Intelligence · Computer Science 2018-09-24 Marjan Najafabadipour , Juan Manuel Tuñas , Alejandro Rodríguez-González , Ernestina Menasalvas

Explaining the predictions of AI models is paramount in safety-critical applications, such as in legal or medical domains. One form of explanation for a prediction is an extractive rationale, i.e., a subset of features of an instance that…

Computation and Language · Computer Science 2020-12-21 Lei Sha , Oana-Maria Camburu , Thomas Lukasiewicz

Clinical trials are critical for drug development. Constructing the appropriate eligibility criteria (i.e., the inclusion/exclusion criteria for patient recruitment) is essential for the trial's success. Proper design of clinical trial…

Computation and Language · Computer Science 2023-10-10 Zifeng Wang , Cao Xiao , Jimeng Sun

Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods…

Machine Learning · Computer Science 2026-03-27 Yongda Fan , John Wu , Andrea Fitzpatrick , Naveen Baskaran , Jimeng Sun , Adam Cross

Outcome prediction from clinical text can prevent doctors from overlooking possible risks and help hospitals to plan capacities. We simulate patients at admission time, when decision support can be especially valuable, and contribute a…

Computation and Language · Computer Science 2021-02-09 Betty van Aken , Jens-Michalis Papaioannou , Manuel Mayrdorfer , Klemens Budde , Felix A. Gers , Alexander Löser

Background: In the information extraction and natural language processing domain, accessible datasets are crucial to reproduce and compare results. Publicly available implementations and tools can serve as benchmark and facilitate the…

Clinical natural language processing (NLP) models have shown promise for supporting hospital discharge planning by leveraging narrative clinical documentation. However, note-based models are particularly vulnerable to temporal and lexical…

Computation and Language · Computer Science 2026-02-20 Ha Na Cho , Sairam Sutari , Alexander Lopez , Hansen Bow , Kai Zheng

With the increasing availability of structured and unstructured data and the swift progress of analytical techniques, Artificial Intelligence (AI) is bringing a revolution to the healthcare industry. With the increasingly indispensable role…

Machine Learning · Computer Science 2020-11-09 Devam Dave , Het Naik , Smiti Singhal , Pankesh Patel

Current approaches to explaining the decisions of deep learning systems for medical tasks have focused on visualising the elements that have contributed to each decision. We argue that such approaches are not enough to "open the black box"…

Artificial Intelligence · Computer Science 2018-06-04 William Gale , Luke Oakden-Rayner , Gustavo Carneiro , Andrew P Bradley , Lyle J Palmer

Neural networks (NNs) have been successfully applied to solve a variety of application problems involving classification and function approximation. Although backpropagation NNs generally predict better than decision trees do for pattern…

Neural and Evolutionary Computing · Computer Science 2010-09-28 S. M. Kamruzzaman

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

In the rapidly evolving field of Explainable Natural Language Processing (NLP), textual explanations, i.e., human-like rationales, are pivotal for explaining model predictions and enriching datasets with interpretable labels. Traditional…

Computation and Language · Computer Science 2025-11-12 Mahdi Dhaini , Juraj Vladika , Ege Erdogan , Zineb Attaoui , Gjergji Kasneci

Neural networks are becoming a popular tool for solving many real-world problems such as object recognition and machine translation, thanks to its exceptional performance as an end-to-end solution. However, neural networks are complex…

Machine Learning · Computer Science 2020-09-29 Guoliang Dong , Jingyi Wang , Jun Sun , Yang Zhang , Xinyu Wang , Ting Dai , Jin Song Dong , Xingen Wang

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

The wide-spread adoption of representation learning technologies in clinical decision making strongly emphasizes the need for characterizing model reliability and enabling rigorous introspection of model behavior. While the former need is…

Machine Learning · Computer Science 2020-05-01 Jayaraman J. Thiagarajan , Prasanna Sattigeri , Deepta Rajan , Bindya Venkatesh

Electronic health records (EHR) contain large volumes of unstructured text, requiring the application of Information Extraction (IE) technologies to enable clinical analysis. We present the open-source Medical Concept Annotation Toolkit…

Transparency in AI healthcare decision-making is crucial. By incorporating rationales to explain reason for each predicted label, users could understand Large Language Models (LLMs)'s reasoning to make better decision. In this work, we…

Computation and Language · Computer Science 2025-08-25 Khai-Nguyen Nguyen , Khai Le-Duc , Bach Phan Tat , Duy Le , Long Vo-Dang , Truong-Son Hy

Computationally explicit hypotheses of brain function derived from machine learning (ML)-based models have recently revolutionized neuroscience. Despite the unprecedented ability of these artificial neural networks (ANNs) to capture…

Neurons and Cognition · Quantitative Biology 2023-12-12 Kohitij Kar , Simon Kornblith , Evelina Fedorenko

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

Computation and Language · Computer Science 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin