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Photothermal-Induced Resonance (PTIR) is increasingly used in the measurement of infrared absorption spectra of sub-micrometer objects. The technique measures IR absorption spectra by relying on the photothermal effect induced by a rapid…

Chemical Physics · Physics 2019-11-28 Luca Quaroni

Photothermal-Induced Resonance (PTIR) spectroscopy and imaging with infrared light has seen increasing application in molecular spectroscopy of biological samples. The appeal of the technique lies in its capability to provide information…

Quantitative Methods · Quantitative Biology 2019-11-19 Luca Quaroni

IR spectroscopy has been widely used for chemical identification and quantitative analysis of reactions occurring in a specific time and space domains by measuring an average signal of the entire system1. Achieving IR measurements with…

Fourier transform infrared nanospectroscopy (nano-FTIR) is a novel, increasingly adopted characterization method that leverages decades of established knowledge in infrared spectroscopy at the nanoscale. It opens up new possibilities in the…

Optics · Physics 2026-05-21 Gergely Nemeth , Ferenc Borondics

Atomic Force Microscopy - Infrared (AFM-IR) has emerged as a useful technique for measuring absorption spectra with spatial resolution better than the optical diffraction limit. The technique relies on the movement of a probe for atomic…

Applied Physics · Physics 2024-01-17 Luca Quaroni

We use photothermal induced resonance (PTIR) imaging and spectroscopy, in resonant and non-resonant mode, to study the cytoplasmic membrane and surface of intact cells. Non-resonant PTIR images apparently provide rich details of the cell…

Applied Physics · Physics 2021-01-27 Luca Quaroni

Researchers from a broad spectrum of scientific and engineering disciplines are increasingly using near-field infrared spectroscopic techniques to characterize materials nondestructively and with nanoscale spatial resolution. However,…

Optics · Physics 2023-03-21 Jonathan M. Larson , Hans A. Bechtel , Robert Kostecki

IR spectroscopy such as Fourier transform infrared spectroscopy (FTIR) are widely used for the investigation of structure and the quantitative determination of substances in the fields of chemistry, physics, biology, medicine, and…

We demonstrate instrumentation and methods to enable fluorescence-detected photothermal infrared (F-PTIR) microscopy, then demonstrate the utility of F-PTIR to characterize the composition within phase-separated domains of model amorphous…

Understanding light-matter interaction at the nanoscale requires probing the optical properties of matter at the individual nano-absorber level. To this end, we have developed a nanomechanical photothermal sensing platform that can be used…

Optics · Physics 2024-06-07 Kostas Kanellopulos , Robert G. West , Silvan Schmid

Accurate direct measurements of far-field thermal infrared emission become increasingly important because conventional methods, relying on indirect assessments, such as reflectance/transmittance, are inaccurate or even unfeasible to…

Instrumentation and Detectors · Physics 2023-03-14 Xiu Liu , Hakan Salihoglu , Xiao Luo , Hyeong Seok Yun , Lin Jing , Bowen Yu , Sheng Shen

We report on infrared (IR) spectro-microscopy of the electronic excitations in nanometer-thick accumulation layers in FET devices based on poly(3-hexylthiophene). IR data allows us to explore the charge injection landscape and uncovers the…

Soft Condensed Matter · Physics 2015-06-25 Z. Q. Li , G. M. Wang , N. Sai , D. Moses , M. C. Martin , M. Di Ventra , A. J. Heeger , D. N. Basov

In nanomechanical photothermal absorption spectroscopy and microscopy, the measured substance becomes a part of the detection system itself, inducing a nanomechanical resonance frequency shift upon thermal relaxation. Suspended,…

Instrumentation and Detectors · Physics 2023-06-30 Robert G. West , Kostas Kanellopulos , Silvan Schmid

Fourier-transform infrared spectroscopy (FTIR) has matured into a versatile technique with relevance for environmental monitoring, pharmaceutical research, and food safety applications. However, compared to other spectroscopic methods, it…

Instrumentation and Detectors · Physics 2024-09-04 Jakub Mnich , Johannes Kunsch , Matthias Budden , Thomas Gebert , Marco Schossig , Jarosław Sotor , Łukasz A. Sterczewski

Photothermal spectroscopy and microscopy provides a route to measure the spectral and spatial properties of individual nanoscopic absorbers, independent from scattering, extinction, and emission. The approach relies upon use of two light…

Optics · Physics 2021-04-12 Harrison J. Goldwyn , Stephan Link , David J. Masiello

Fourier-transform infrared spectroscopy (FTIR) is a powerful analytical method for not only the chemical identification of solid, liquid, and gas species, but also the quantification of their concentration. However, the chemical…

Fourier-transform infrared spectroscopy (FTIR) is an indispensable analytical method that allows label-free identification of substances via fundamental molecular vibrations. However, the sensitivity of FTIR is often limited by the low…

Anisotropic intensity distributions on nanostructured surfaces and polarization-sensitive spectra have been observed in a number of nanoscale infrared spectroscopic imaging methods, including nano-FTIR [Bakir et al., Molecules, 2020, 25,…

Tip enhanced IR spectra and imaging have been widely used in cutting-edge studies for the in-depth understanding of the composition, structure and function of interfaces at the nanoscale. However, molecular monolayer sensitivity has only…

Infrared (IR) spectroscopy, a well established tool for chemical analysis of diverse materials, has significant potential in biomedical applications. While the spatial resolution of traditional IR spectroscopy is limited by the wavelength…

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