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Many cellular processes require a polarization axis which generally initially emerges as an inhomogeneous distribution of molecular markers in the cell. We present a simple analytical model of a general mechanism of cell polarization taking…

Cell Behavior · Quantitative Biology 2009-10-21 Rhoda J. Hawkins , Olivier Benichou , Matthieu Piel , Raphael Voituriez

The spreading of infectious diseases with and without immunization of individuals can be modeled by stochastic processes that exhibit a transition between an active phase of epidemic spreading and an absorbing phase, where the disease dies…

Statistical Mechanics · Physics 2009-11-10 Stephan M. Dammer , Haye Hinrichsen

We develop a phase-field model for evaporation from a porous medium by explicitly considering a vapor component together with the liquid and gas phases in the system. The phase-field model consists of the conservation of mass (for phases…

Analysis of PDEs · Mathematics 2024-07-26 Tufan Ghosh , Carina Bringedal , Christian Rohde , Rainer Helmig

In this paper, we bring together our efforts in identifying and understanding nonequilibrium phase segregation driven by active processes in the living cell, with special focus on the segregation of cell membrane components driven by active…

Soft Condensed Matter · Physics 2022-05-04 Ajay Bansal , Amit Das , Madan Rao

The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

Phase transitions to absorbing states are among the simplest examples of critical phenomena out of equilibrium. The characteristic feature of these models is the presence of a fluctuationless configuration which the dynamics cannot leave,…

Imbibition plays a central role in diverse energy, environmental, and industrial processes. In many cases, the medium has multiple parallel strata of different permeabilities; however, how this stratification impacts imbibition is poorly…

We present a novel computational modeling framework to numerically investigate fluid-structure interaction in viscous fluids using the phase field embedding method. Each rigid body or elastic structure immersed in the incompressible viscous…

Fluid Dynamics · Physics 2021-09-16 Qi Hong , Qi Wang

This work deals with numerical simulation of water freezing and thawing in a complex three-dimensional geometry of a porous medium. The porous structure is represented by a virtual container filled with glass beads. Phase transition…

Computational Physics · Physics 2024-07-23 Pavel Strachota

We introduce a model for a population on a lattice with diffusion and birth/death according to 2A->3A and A->0 for a particle A. We find that the model displays a phase transition from an active to an absorbing state which is continuous in…

Statistical Mechanics · Physics 2015-06-25 Alastair Windus , Henrik Jeldtoft Jensen

We consider the interaction between a poroelastic structure, described using the Biot model in primal form, and a free-flowing fluid, modelled with the time-dependent incompressible Stokes equations. We propose a diffuse interface model in…

Numerical Analysis · Mathematics 2024-07-09 Francis R. A. Aznaran , Martina Bukač , Boris Muha , Abner J. Salgado

Given a $generic$ two-dimensional conformal field theory (CFT), we propose an analytically solvable setup to study the Floquet dynamics of the CFT, i.e., the dynamics of a CFT subject to a periodic driving. A complete phase diagram in the…

Strongly Correlated Electrons · Physics 2018-05-23 Xueda Wen , Jie-Qiang Wu

Microphase separation of membrane components is thought to play an important role in many physiological processes, from cell signaling to endocytosis and cellular trafficking. Here, we study how variations in the membrane composition can be…

Subcellular Processes · Quantitative Biology 2015-05-20 Pierre Sens , Matthew S. Turner

We study a simplified model of monoclonal antibodies confined in a patchy random porous medium. Antibodies are represented as Y-shaped particles composed of seven tangential hard spheres with attractive patches on the terminal beads, while…

Soft Condensed Matter · Physics 2026-03-31 Yu. V. Kalyuzhnyi , T. Patsahan

We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including hematocrit, the deformability of the cells and the Reynolds number. A detailed mesoscopic hydrodynamic…

Biological Physics · Physics 2016-04-20 Wieland Marth , Axel Voigt

A thermodynamically consistent phase-field model is introduced for simulating multicellular deformation, and aggregation under flow conditions. In particular, a Lennard-Jones type potential is proposed under the phase-field framework for…

Numerical Analysis · Mathematics 2022-05-17 Lingyue Shen , Ping Lin , Zhiliang Xu , Shixin Xu

The phase-field method is used as a basis to develop a strictly mass conserving, yet simple, model for simulation of two-phase flow. The model is aimed to be applied for the study of structure evolution in metallic foams. In this regard,…

Computational Physics · Physics 2020-07-14 Samad Vakili , Ingo Steinbach , Fathollah Varnik

We simulate the electrical response of multiple disjoint biological 3D cells undergoing an electropermeabilization process. Instead of solving the boundary value problem in the unbounded volume, we reduce it to a system of boundary…

Computational Engineering, Finance, and Science · Computer Science 2024-09-04 Isabel A. Martínez Ávila , Carlos Jerez-Hanckes , Irina Pettersson

We introduce a new phase-field model which allows for simulation of incoherent solid/solid transformations. Contrary to previous models which impose coherency at the interface, the zero shear-stress condition characteristic of incoherent…

Materials Science · Physics 2007-05-23 Jerome Paret

Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix via mechanochemical pathways. The clustering of specific lipids and lipid-anchored…

Biological Physics · Physics 2022-08-05 Tapas Singha , Anirban Polley , Mustansir Barma