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With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, we need a revolutionary sequencing method for the…

Biological Physics · Physics 2008-01-03 Michael Zwolak , Massimiliano Di Ventra

The ability to rapidly manufacture building blocks with specific binding interactions is a key aspect of programmable assembly. Recent developments in DNA nanotechnology and colloidal particle synthesis have significantly advanced our…

Soft Condensed Matter · Physics 2024-03-06 Chrisy Xiyu Du , Hanyu Alice Zhang , Tanner Pearson , Jakin Ng , Paul McEuen , Itai Cohen , Michael P. Brenner

We investigate diffusion-limited reactions between a diffusing particle and a target site on a semiflexible polymer, a key factor determining the kinetics of DNA-protein binding and polymerization of cytoskeletal filaments. Our theory…

Soft Condensed Matter · Physics 2010-12-08 Yann von Hansen , Roland R. Netz , Michael Hinczewski

The nanoscale interaction between single emitters and plasmonic structures is traditionally studied by relying on near-perfect, deterministic, nanoscale-control. This approach is ultra-low throughput thus rendering systematic studies…

Chemical Physics · Physics 2019-04-29 Lisa Saemisch , Matz Liebel , Niek van Hulst

Tethered particle experiments use light microscopy to measure the position of a micrometer-sized bead tethered to a microscope slide via a ~micrometer length polymer, in order to infer the behavior of the invisible polymer. Currently, this…

Biological Physics · Physics 2009-11-13 John F. Beausang , Chiara Zurla , Carlo Manzo , David Dunlap , Laura Finzi , Philip C. Nelson

A key objective in DNA-based material science is understanding and precisely controlling the mechanical properties of DNA hydrogels. We perform microrheology measurements using diffusing-wave spectroscopy (DWS) to investigate the…

Experiments have reached a monumental capacity for designing and synthesizing microscopic particles for self-assembly, making it possible to precisely control particle concentrations, shapes, and interactions. However, more physical insight…

Soft Condensed Matter · Physics 2026-02-19 Maximilian C. Hübl , Thomas E. Videbæk , Daichi Hayakawa , W. Benjamin Rogers , Carl P. Goodrich

In this review we focus on the idea of establishing connections between the mechanical properties of DNAligand complexes and the physical chemistry of DNA-ligand interactions. This type of connection is interesting because it opens the…

Biological Physics · Physics 2015-04-20 M. S. Rocha

The unconstrained genomic DNA of bacteria forms a coil, which volume exceeds 1000 times the volume of the cell. Since prokaryotes lack a membrane-bound nucleus, in sharp contrast with eukaryotes, the DNA may consequently be expected to…

Biomolecules · Quantitative Biology 2015-09-09 Marc Joyeux

The optics of correlated disordered media is a fascinating research topic emerging at the interface between the physics of waves in complex media and nanophotonics. Inspired by photonic structures in nature and enabled by advances in…

Electromagnetic interaction between a sub-wavelength particle (the `probe') and a material surface (the `sample') is studied theoretically. The interaction is shown to be governed by a series of resonances corresponding to surface polariton…

Mesoscale and Nanoscale Physics · Physics 2016-02-11 B. -Y. Jiang , L. M. Zhang , A. H. Castro Neto , D. N. Basov , M. M. Fogler

The complexity of condensed matter arises from emergent behaviors that cannot be understood by analyzing individual constituents in isolation. While traditional condensed-matter approaches-developed primarily for ideal crystalline…

Materials Science · Physics 2025-09-30 Elisabetta Nocerino

Plasmonic nanoparticles (NPs) integrated within thermoresponsive polymeric microgels provide a versatile platform for the realization of stimuli-responsive optical materials, where the microgel volume phase transition enables dynamic…

Self-assemblies, structured via nanoparticles, show promise as materials for advanced applications, like photonic devices, electrochemical energy storage units and catalysis support. Despite observing diverse morphologies, a comprehensive…

The three-dimensional organization of chromatin is thought to play an important role in controlling gene expression. Specificity in expression is achieved through the interaction of transcription factors and other nuclear proteins with…

Biological Physics · Physics 2025-07-22 Mason N. Rouches , Benjamin B. Machta

Motivated by the theoretical observation that isotropic chirality can exist even in completely random systems, we design a dielectric metamaterial consisting of a random colloid of meta-atoms, which exhibits unprecedentedly high isotropic…

Optics · Physics 2020-10-09 Viktar Asadchy , Cheng Guo , Ihar Faniayeu , Shanhui Fan

Heller et. Al. (Science 311, 508 (2006)) demonstrated the first DNA-CN optical sensor by wrapping a piece of double-stranded DNA around the surface of single-walled carbon nanotubes (CN). This new type of optical device can be placed inside…

Mesoscale and Nanoscale Physics · Physics 2012-09-25 Anh D. Phan , Dustin A. Tracy , N. A. Viet

Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic…

Our visual perception of our surroundings is ultimately limited by the diffraction limit, which stipulates that optical information smaller than roughly half the illumination wavelength is not retrievable. Over the past decades, many…

With the help of one-dimensional random Potts-like model we study the origins of fine structure observed on differential melting profiles of double-stranded DNA. We assess the effects of sequence arrangement on DNA melting curves through…

Soft Condensed Matter · Physics 2024-04-11 Arevik V. Asatryan , Albert S. Benight , Artem V. Badasyan