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We present new analytical and numerical results for the elliptic-parabolic system of partial differential equations proposed by Hu and Cai, which models the formation of biological transport networks. The model describes the pressure field…

Analysis of PDEs · Mathematics 2015-10-14 Jan Haskovec , Peter Markowich , Benoit Perthame , Matthias Schlottbom

We compare the solutions of two systems of partial differential equations (PDE), seen as two different interpretations of the same model that describes formation of complex biological networks. Both approaches take into account the time…

Numerical Analysis · Mathematics 2023-07-20 Clarissa Astuto , Daniele Boffi , Jan Haskovec , Peter Markowich , Giovanni Russo

Motivated by recent physics papers describing rules for natural network formation, we study an elliptic-parabolic system of partial differential equations proposed by Hu and Cai. The model describes the pressure field thanks to Darcy's type…

Analysis of PDEs · Mathematics 2014-05-09 Jan Haskovec , Peter Markowich , Benoit Perthame

We study self-regulating processes modeling biological transportation networks. Firstly, we write the formal $L^2$-gradient flow for the symmetric tensor valued diffusivity $D$ of a broad class of entropy dissipations associated with a…

Analysis of PDEs · Mathematics 2024-03-14 Jan Haskovec , Peter Markowich , Simone Portaro

Starting with sets of disorganized observations of spatially varying and temporally evolving systems, obtained at different (also disorganized) sets of parameters, we demonstrate the data-driven derivation of parameter dependent,…

Dynamical Systems · Mathematics 2022-04-27 David W. Sroczynski , Felix P. Kemeth , Ronald R. Coifman , Ioannis G. Kevrekidis

In recent years, the study of biological transportation networks has attracted significant interest, focusing on their self-regulating, demand-driven nature. This paper examines a mathematical model for these networks, featuring nonlinear…

Analysis of PDEs · Mathematics 2024-08-29 Clarissa Astuto , Peter Markowich , Simone Portaro , Giovanni Russo

The Transformer architecture has revolutionized artificial intelligence, yet a principled theoretical understanding of its internal mechanisms remains elusive. This paper introduces a novel analytical framework that reconceptualizes the…

Machine Learning · Computer Science 2025-09-30 Yukun Zhang , Xueqing Zhou

We introduce a mesoscopic model for natural network formation processes, acting as a bridge between the discrete and continuous network approach proposed by Hu and Cai. The models are based on a common approach where the dynamics of the…

Analysis of PDEs · Mathematics 2018-06-07 Martin Burger , Jan Haskovec , Peter Markowich , Helene Ranetbauer

We are concerned with a system of partial differential equations describing internal flows of homogeneous incompressible fluids of Bingham type in which the value of activation (the so-called yield) stress depends on the internal pore…

Analysis of PDEs · Mathematics 2019-06-11 Anna Abbatiello , Tomáš Los , Josef Málek , Ondřej Souček

A finite element discretization is developed for the Cai-Hu model, describing the formation of biological networks. The model consists of a non linear elliptic equation for the pressure $p$ and a non linear reaction-diffusion equation for…

Numerical Analysis · Mathematics 2025-03-28 Clarissa Astuto , Daniele Boffi , Fabio Credali

Recent research has used deep learning to develop partial differential equation (PDE) models in science and engineering. The functional form of the PDE is determined by a neural network, and the neural network parameters are calibrated to…

Machine Learning · Computer Science 2023-10-17 Justin Sirignano , Jonathan MacArt , Konstantinos Spiliopoulos

This work presents a physics-conditioned latent diffusion model tailored for dynamical downscaling of atmospheric data, with a focus on reconstructing high-resolution 2-m temperature fields. Building upon a pre-existing diffusion…

Machine Learning · Computer Science 2025-10-29 Paul Rosu , Muchang Bahng , Erick Jiang , Rico Zhu , Vahid Tarokh

We propose a mesoscopic modeling framework for optimal transportation networks with biological applications. The network is described in terms of a joint probability measure on the phase space of tensor-valued conductivity and position in…

Analysis of PDEs · Mathematics 2024-01-23 Jan Haskovec , Peter Markowich , Simone Portaro

In this article we propose and investigate a hierarchy of mathematical models based on partial differential equations (PDE) and ordinary differential equations (ODE) for the simulation of the biophysical phenomena occurring in the…

Numerical Analysis · Mathematics 2016-01-20 Emanuela Abbate , Matteo Porro , Thierry Nieus , Riccardo Sacco

In this work, we consider a certain multilayered (thick layer) wave--(thin layer) wave--heat (fluid) interactive PDE system. Such coupled PDE systems have been used in the literature to describe the blood transport process in mammalian…

Analysis of PDEs · Mathematics 2022-01-13 George Avalos , Pelin G. Geredeli , Boris Muha

This paper presents a mathematical analysis of an elliptic partial differential equation (PDE) designed to compute the geometric thickness of a given shape. The PDE-based formulation provides a direct and systematic approach to evaluate…

Analysis of PDEs · Mathematics 2025-11-18 Atsushi Nakayasu , Takayuki Yamada

The structure of a network has a major effect on dynamical processes on that network. Many studies of the interplay between network structure and dynamics have focused on models of phenomena such as disease spread, opinion formation and…

Dynamical Systems · Mathematics 2025-10-21 Lucas Böttcher , Mason A. Porter

We derive from particle-level dynamics a constitutive model describing the rheology of two-dimensional dense soft suspensions below the jamming transition, in a regime where hydrodynamic interactions between particles are screened. Based on…

Soft Condensed Matter · Physics 2026-01-08 N. Cuny , E. Bertin , R. Mari

We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…

Analysis of PDEs · Mathematics 2021-09-23 Pavel Krejci , Elisabetta Rocca , Juergen Sprekels

In this paper we investigate regularity properties of weak solutions to a PDE system that arises in the study of biological transport networks. The system consists of a possibly singular elliptic equation for the scalar pressure of the…

Analysis of PDEs · Mathematics 2018-01-03 Jian-Guo Liu , Xiangsheng Xu
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