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Dynamic Causal Modelling (DCM) is the predominant method for inferring effective connectivity from neuroimaging data. In the 15 years since its introduction, the neural models and statistical routines in DCM have developed in parallel,…

Quantitative Methods · Quantitative Biology 2019-07-15 Peter Zeidman , Amirhossein Jafarian , Nadège Corbin , Mohamed L. Seghier , Adeel Razi , Cathy J. Price , Karl J. Friston

The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…

Many fMRI analyses examine functional connectivity, or statistical dependencies among remote brain regions. Yet popular methods for studying whole-brain functional connectivity often yield results that are difficult to interpret. Factor…

Methodology · Statistics 2024-09-24 Kyle Stanley , Nicole Lazar , Matthew Reimherr

Functional connectivity quantifies the statistical dependencies between the activity of brain regions, measured using neuroimaging data such as functional MRI BOLD time series. The network representation of functional connectivity, called a…

Neurons and Cognition · Quantitative Biology 2020-11-23 Benjamin Chiêm , Kausar Abbas , Enrico Amico , Duy Anh Duong-Tran , Frédéric Crevecoeur , Joaquín Goñi

Brain networks are typically represented by adjacency matrices, where each node corresponds to a brain region. In traditional brain network analysis, nodes are assumed to be matched across individuals, but the methods used for node matching…

Methodology · Statistics 2025-03-21 Martin Cole , Yang Xiang , Will Consagra , Anuj Srivastava , Xing Qiu , Zhengwu Zhang

Analysis of brain connectivity is important for understanding how information is processed by the brain. We propose a novel Bayesian vector autoregression (VAR) hierarchical model for analyzing brain connectivity in a resting-state fMRI…

Applications · Statistics 2021-12-09 Bertil Wegmann , Anders Lundquist , Anders Eklund , Mattias Villani

In recent years, new and important perspectives were introduced in the field of neuroimaging with the emergence of the connectionist approach. In this new context, it is important to know not only which brain areas are activated by a…

Neurons and Cognition · Quantitative Biology 2019-04-17 Jean Faber , Priscila C. Antoneli , Guillem Via , Noemi S. Araújo , Daniel J. L. L. Pinheiro , Esper Cavalheiro

There are two fundamental problems in applying deep learning/machine learning methods to disease classification tasks, one is the insufficient number and poor quality of training samples; another one is how to effectively fuse multiple…

Machine Learning · Computer Science 2023-07-25 Menglin Kong , Shaojie Zhao , Juan Cheng , Xingquan Li , Ri Su , Muzhou Hou , Cong Cao

Brain activation and connectivity analyses in task-based functional magnetic resonance imaging (fMRI) experiments with multiple subjects are currently at the forefront of data-driven neuroscience. In such experiments, interest often lies in…

Applications · Statistics 2019-04-02 Daniel Spencer , Rajarshi Guhaniyogi , Raquel Prado

Functional connectivity refers to the temporal statistical relationship between spatially distinct brain regions and is usually inferred from the time series coherence/correlation in brain activity between regions of interest. In human…

Machine Learning · Statistics 2015-03-02 Shaurabh Nandy , Richard M. Golden

In recent years, graph neural networks (GNNs) have been widely applied in the analysis of brain fMRI, yet defining the connectivity between ROIs remains a challenge in noisy fMRI data. Among all approaches, Functional Connectome (FC) is the…

Machine Learning · Computer Science 2025-04-09 Jiyao Wang , Nicha C. Dvornek , Peiyu Duan , Lawrence H. Staib , Pamela Ventola , James S. Duncan

Fuzzy Cognitive Maps (FCMs) are considered a soft computing technique combining elements of fuzzy logic and recurrent neural networks. They found multiple application in such domains as modeling of system behavior, prediction of time…

Machine Learning · Computer Science 2021-03-16 Piotr Szwed

Brain connectivity analysis is crucial for understanding brain structure and neurological function, shedding light on the mechanisms of mental illness. To study the association between individual brain connectivity networks and the clinical…

Functional Magnetic Resonance Imaging (fMRI) is an imaging technique widely used to study human brain activity. fMRI signals in areas across the brain transiently synchronise and desynchronise their activity in a highly structured manner,…

Machine Learning · Computer Science 2025-08-12 Yiran Huang , Amirhossein Nouranizadeh , Christine Ahrends , Mengjia Xu

It has become increasingly popular to study the brain as a network due to the realization that functionality cannot be explained exclusively by independent activation of specialized regions. Instead, across a large spectrum of behaviors,…

Neurons and Cognition · Quantitative Biology 2014-07-22 Petko Bogdanov , Nazli Dereli , Danielle S. Bassett , Scott T. Grafton , Ambuj K. Singh

Functional brain connectivity, as revealed through distant correlations in the signals measured by functional Magnetic Resonance Imaging (fMRI), is a promising source of biomarkers of brain pathologies. However, establishing and using…

Accounting for inter-individual variability in brain function is key to precision medicine. Here, by considering functional inter-individual variability as meaningful data rather than noise, we introduce VarCoNet, an enhanced…

Neural and Evolutionary Computing · Computer Science 2025-10-06 Charalampos Lamprou , Aamna Alshehhi , Leontios J. Hadjileontiadis , Mohamed L. Seghier

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

An unprecedented amount of existing functional Magnetic Resonance Imaging (fMRI) data provides a new opportunity to understand the relationship between functional fluctuation and human cognition/behavior using a data-driven approach. To…

Machine Learning · Computer Science 2024-09-18 Jiaqi Ding , Tingting Dan , Ziquan Wei , Hyuna Cho , Paul J. Laurienti , Won Hwa Kim , Guorong Wu

Motivated by image-on-scalar regression with data aggregated across multiple sites, we consider a setting in which multiple independent studies each collect multiple dependent vector outcomes, with potential mean model parameter homogeneity…

Methodology · Statistics 2022-10-06 Emily C. Hector
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