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We consider a state-constrained optimal control problem of a system of two non-local partial-differential equations, which is an extension of the one introduced in a previous work in mathematical oncology. The aim is to minimize the tumor…

Optimization and Control · Mathematics 2018-01-18 Antoine Olivier , Camille Pouchol

We introduce a policy model coupled with the susceptible-infected-recovered (SIR) epidemic model to study interactions between policy-making and the dynamics of epidemics. We consider both single-region policies, as well as game-theoretic…

Optimization and Control · Mathematics 2024-08-06 Xia Li , Andrea L. Bertozzi , P. Jeffrey Brantingham , Yevgeniy Vorobeychik

Optimal Control (OC) is the process of determining control and state trajectories for a dynamic system, over a period of time, in order to optimize a given performance index. With the increasing of variables and complexity, OC problems can…

Optimization and Control · Mathematics 2014-09-02 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

Pandemics involve the high transmission of a disease that impacts global and local health and economic patterns. The impact of a pandemic can be minimized by enforcing certain restrictions on a community. However, while minimizing infection…

Artificial Intelligence · Computer Science 2024-02-13 Ishir Rao

This article describes a new, efficient way of finding control and state trajectories in optimal control problems by reformulation as a system of differential-algebraic equations (DAEs). The optimal control and state vectors can be obtained…

Systems and Control · Electrical Eng. & Systems 2025-06-13 Prakitr Srisuma , George Barbastathis , Richard D. Braatz

Therapeutic strategies to correct an excessive immune response to pathogenic infection is investigated as an optimal control problem. The control problem is formulated around a four dimensional mathematical model describing the inflammatory…

Optimization and Control · Mathematics 2017-04-20 Ouassim Bara , Seddik Djouadi , Judy Day , Suzanne Lenhart

Nowadays, epidemic models provide an appropriate tool for describing the propagation of biological viruses in human or animal populations, or rumours and other kinds of information in social networks and malware in both computer and ad hoc…

Optimization and Control · Mathematics 2020-07-21 Vladislav Taynitskiy , Elena Gubar , Denis Fedyanin , Ilya Petrov , Quanyan Zhu

In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion…

Optimization and Control · Mathematics 2021-04-21 Harald Garcke , Kei Fong Lam , Andrea Signori

In this paper, we explore the interplay between Predictive Control and closed-loop optimality, spanning from Model Predictive Control to Data-Driven Predictive Control. Predictive Control in general relies on some form of prediction scheme…

Optimization and Control · Mathematics 2024-05-29 Akhil S Anand , Shambhuraj Sawant , Dirk Reinhardt , Sebastien Gros

The development of connected and automated vehicles is the key to improving urban mobility safety and efficiency. This paper focuses on cooperative vehicle management at a signal-free intersection with consideration of vehicle modeling…

Optimization and Control · Mathematics 2024-10-28 Xiao Pan , Boli Chen , Li Dai , Stelios Timotheou , Simos A. Evangelou

State-of-the-art probabilistic model checkers perform verification on explicit-state Markov models defined in a high-level programming formalism like the PRISM modeling language. Typically, the low-level models resulting from such…

Logic in Computer Science · Computer Science 2021-11-15 Tobias Winkler , Johannes Lehmann , Joost-Pieter Katoen

"Model-free control" and the corresponding "intelligent" PID controllers (iPIDs), which already had many successful concrete applications, are presented here for the first time in an unified manner, where the new advances are taken into…

Optimization and Control · Mathematics 2013-11-21 Michel Fliess , Cédric Join

Optimal control of interdependent epidemics spreading over complex networks is a critical issue. We first establish a framework to capture the coupling between two epidemics, and then analyze the system's equilibrium states by categorizing…

Systems and Control · Computer Science 2017-10-19 Juntao Chen , Rui Zhang , Quanyan Zhu

Epidemic models are useful tools in the fight against infectious diseases, as they allow policy makers to test and compare various strategies to limit disease transmission while mitigating collateral damage on the economy. Epidemic models…

Populations and Evolution · Quantitative Biology 2021-08-18 Joseph D. Peterson , Ronojoy Adhikari

This paper introduces a continuous-time constrained nonlinear control scheme which implements a model predictive control strategy as a continuous-time dynamic system. The approach is based on the idea that the solution of the optimal…

Systems and Control · Computer Science 2017-09-20 Marco M. Nicotra , Dominic Liao-McPherson , Ilya V. Kolmanovsky

We design and analyze a multi-level game-theoretic model of hierarchical policy interventions for epidemic control, such as those in response to the COVID-19 pandemic. Our model captures the potentially mismatched priorities among a…

Computer Science and Game Theory · Computer Science 2022-08-05 Feiran Jia , Aditya Mate , Zun Li , Shahin Jabbari , Mithun Chakraborty , Milind Tambe , Michael Wellman , Yevgeniy Vorobeychik

Model-free learning-based control methods have seen great success recently. However, such methods typically suffer from poor sample complexity and limited convergence guarantees. This is in sharp contrast to classical model-based control,…

Optimization and Control · Mathematics 2020-06-16 Guannan Qu , Chenkai Yu , Steven Low , Adam Wierman

In this paper, we address the issue of model specification in probabilistic latent variable models (PLVMs) using an infinite-horizon optimal control approach. Traditional PLVMs rely on joint distributions to model complex data, but…

Systems and Control · Electrical Eng. & Systems 2025-07-29 Zhichao Chen , Hao Wang , Licheng Pan , Yiran Ma , Yunfei Teng , Jiaze Ma , Le Yao , Zhiqiang Ge , Zhihuan Song

We propose a neural network approach for solving high-dimensional optimal control problems. In particular, we focus on multi-agent control problems with obstacle and collision avoidance. These problems immediately become high-dimensional,…

Optimization and Control · Mathematics 2022-05-05 Derek Onken , Levon Nurbekyan , Xingjian Li , Samy Wu Fung , Stanley Osher , Lars Ruthotto

The adoption of containment measures to reduce the amplitude of the epidemic peak is a key aspect in tackling the rapid spread of an epidemic. Classical compartmental models must be modified and studied to correctly describe the effects of…

Populations and Evolution · Quantitative Biology 2021-05-18 G. Albi , L. Pareschi , M. Zanella