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Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured…

Machine Learning · Computer Science 2025-02-25 Bishal Thapaliya , Esra Akbas , Jiayu Chen , Raam Sapkota , Bhaskar Ray , Pranav Suresh , Vince Calhoun , Jingyu Liu

In recent years, neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach toward developing integrated, multivariate brain models that can predict categories of mental events. However, large…

Applications · Statistics 2022-09-19 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

We investigate whether and how we can improve the cost efficiency of neuroimaging studies with well-tailored fMRI tasks. The comparative study is conducted using a novel network science-driven Bayesian connectome-based predictive method,…

Applications · Statistics 2024-11-05 Xinzhi Zhang , Leslie A Hulvershorn , Todd Constable , Yize Zhao , Selena Wang

Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

Neurons and Cognition · Quantitative Biology 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Cognitive fatigue, which transitions from focused attention to inexact responses, can cause catastrophic failures in high-stakes environments, yet current black-box assessment techniques ignore the brain's non-Markovian and time-varying…

Human-Computer Interaction · Computer Science 2026-05-05 Zeinabsadat Saghi , Daria Riabukhina , Olubukola Akinbami , Paul Bogdan , Souti Chattopadhyay

In recent years, Bayesian statistics methods in neuroscience have been showing important advances. In particular, detection of brain signals for studying the complexity of the brain is an active area of research. Functional magnetic…

Methodology · Statistics 2017-06-06 Jairo Alberto Fuquene Patiño , Brenda Betancourt , João B. M. Pereira

A major tenet in theoretical neuroscience is that cognitive and behavioral processes are ultimately implemented in terms of the neural system dynamics. Accordingly, a major aim for the analysis of neurophysiological measurements should lie…

Machine Learning · Computer Science 2020-07-01 Georgia Koppe , Hazem Toutounji , Peter Kirsch , Stefanie Lis , Daniel Durstewitz

We present a data-driven framework to characterize large-scale brain dynamical states directly from correlation matrices at the single-subject level. By treating correlation thresholding as a percolation-like probe of connectivity, the…

The application of deep learning (DL) models to neuroimaging data poses several challenges, due to the high dimensionality, low sample size and complex temporo-spatial dependency structure of these datasets. Even further, DL models act as…

Machine Learning · Computer Science 2019-04-08 Armin W. Thomas , Hauke R. Heekeren , Klaus-Robert Müller , Wojciech Samek

Alzheimer's disease (AD) is a neurodegenerative disorder marked by memory loss and cognitive decline, making early detection vital for timely intervention. However, early diagnosis is challenging due to the heterogeneous presentation of…

Neurons and Cognition · Quantitative Biology 2025-09-24 Ali Khazaee , Abdolreza Mohammadi , Ruairi O'Reilly

Non-invasive methods to measure brain activity are important to understand cognitive processes in the human brain. A prominent example is functional magnetic resonance imaging (fMRI), which is a noisy measurement of a delayed signal that…

Neurons and Cognition · Quantitative Biology 2020-08-17 Hans-Christian Ruiz-Euler , Jose R. Ferreira Marques , Hilbert J. Kappen

The technology of functional Magnetic Resonance Imaging (fMRI) based on Blood Oxygen Level Dependent (BOLD) signal has been widely used in clinical treatments and brain function researches. The BOLD signal has to be preprocessed before…

Neurons and Cognition · Quantitative Biology 2017-12-29 Yunxiang Ge , Yu Pan , Weibei Dou

Recent advances in multimodal large language models (LLMs) have enabled unified reasoning across images, audio, and video, but extending such capability to brain imaging remains largely unexplored. Bridging this gap is essential to link…

Computation and Language · Computer Science 2026-05-15 Yuxiang Wei , Yanteng Zhang , Xi Xiao , Chengxuan Qian , Tianyang Wang , Vince D. Calhoun

A Multiregression Dynamic Model (MDM) is a class of multivariate time series that represents various dynamic causal processes in a graphical way. One of the advantages of this class is that, in contrast to many other Dynamic Bayesian…

Methodology · Statistics 2015-05-27 Lilia Costa , Jim Smith , Thomas Nichols , James Cussens , Eugene P. Duff , Tamar R. Makin

Decision making can be a complex process requiring the integration of several attributes of choice options. Understanding the neural processes underlying (uncertain) investment decisions is an important topic in neuroeconomics. We analyzed…

Applications · Statistics 2025-01-08 Piotr Majer , Peter N. C. Mohr , Hauke R. Heekeren , Wolfgang K. Härdle

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

Tissues and Organs · Quantitative Biology 2026-04-17 Qianyu Chen , Shujian Yu

In this technical note, we address an unresolved challenge in neuroimaging statistics: how to determine which of several datasets is the best for inferring neuronal responses. Comparisons of this kind are important for experimenters when…

Equation discovery provides a grey-box approach to system identification by uncovering governing dynamics directly from observed data. However, a persistent challenge lies in ensuring that identified models generalise across operating…

Machine Learning · Computer Science 2025-10-01 S C Bee , N Dervilis , K Worden , L A Bull

Functional Magnetic Resonance Image (fMRI) is commonly employed to study human brain activity, since it offers insight into the relationship between functional fluctuations and human behavior. To enhance analysis and comprehension of brain…

Artificial Intelligence · Computer Science 2025-02-04 Song Wang , Zhenyu Lei , Zhen Tan , Jiaqi Ding , Xinyu Zhao , Yushun Dong , Guorong Wu , Tianlong Chen , Chen Chen , Aiying Zhang , Jundong Li