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The ability to predict the future trajectory of a patient is a key step toward the development of therapeutics for complex diseases such as Alzheimer's disease (AD). However, most machine learning approaches developed for prediction of…

In diagnosing challenging conditions such as Alzheimer's disease (AD), imaging is an important reference. Non-imaging patient data such as patient information, genetic data, medication information, cognitive and memory tests also play a…

Machine Learning · Computer Science 2023-06-01 Yingjie Feng , Jun Wang , Xianfeng Gu , Xiaoyin Xu , Min Zhang

Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that…

Machine Learning · Statistics 2017-08-16 Lev E. Givon , Laura J. Mariano , David O'Dowd , John M. Irvine , Abraham R. Schneider

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

Recent studies on modelling the progression of Alzheimer's disease use a single modality for their predictions while ignoring the time dimension. However, the nature of patient data is heterogeneous and time dependent which requires models…

Computers and Society · Computer Science 2021-10-19 Sofia Lahrichi , Maryem Rhanoui , Mounia Mikram , Bouchra El Asri

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care to delay further progression. This paper presents the development of a state-of-the-art Conformer based speech recognition system built on the…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Tianzi Wang , Jiajun Deng , Mengzhe Geng , Zi Ye , Shoukang Hu , Yi Wang , Mingyu Cui , Zengrui Jin , Xunying Liu , Helen Meng

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Soyabul Islam Lincoln , Mirza Mohd Shahriar Maswood

Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Kilian Hett , Vinh-Thong Ta , Jose Vicente Manjon , Pierrick Coupé

Machine learning has shown promise for automatic detection of Alzheimer's disease (AD) through speech; however, efforts are hampered by a scarcity of data, especially in languages other than English. We propose a method to learn a…

Computation and Language · Computer Science 2019-06-04 Bai Li , Yi-Te Hsu , Frank Rudzicz

Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise…

Computation and Language · Computer Science 2025-12-25 Zhongren Dong , Haotian Guo , Weixiang Xu , Huan Zhao , Zixing Zhang

Despite progress in deep learning for Alzheimer's disease (AD) diagnostics, models trained on structural magnetic resonance imaging (sMRI) often do not perform well when applied to new cohorts due to domain shifts from varying scanners,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Zobia Batool , Diala Lteif , Vijaya B. Kolachalama , Huseyin Ozkan , Erchan Aptoula

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders worldwide. As it progresses, it leads to the deterioration of cognitive functions. Since AD is irreversible, early diagnosis is crucial for managing its…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mahdieh Behjat Khatooni , Mohsen Soryani

The early diagnosis of Alzheimer's Disease (AD) through non invasive methods remains a significant healthcare challenge. We present NeuroXVocal, a novel dual-component system that not only classifies but also explains potential AD cases…

Dementia and especially Alzheimer's disease (AD) are the most common causes of cognitive decline in elderly people. A spread of the above mentioned mental health problems in aging societies is causing a significant medical and economic…

Neurons and Cognition · Quantitative Biology 2018-12-03 Tomasz M. Rutkowski , Qibin Zhao , Masao S. Abe , Mihoko Otake

Automatic Speech Recognition (ASR) plays an important role in speech-based automatic detection of Alzheimer's disease (AD). However, recognition errors could propagate downstream, potentially impacting the detection decisions. Recent…

Computation and Language · Computer Science 2024-12-10 Jiawen Kang , Junan Li , Jinchao Li , Xixin Wu , Helen Meng

Automated speech analysis is a thriving approach to detect early markers of Alzheimer's disease (AD). Yet, recording conditions in most AD datasets are heterogeneous, with patients and controls often evaluated in different acoustic…

Alzheimer's disease is a progressive neurodegenerative disorder in which mild cognitive impairment (MCI) marks a critical transition between aging and dementia. Neuroimaging modalities, such as structural MRI, provide biomarkers of this…

Machine Learning · Computer Science 2026-03-02 Vrushank Ahire , Yogesh Kumar , Anouck Girard , M. A. Ganaie

With people living longer than ever, the number of cases with dementia such as Alzheimer's disease increases steadily. It affects more than 46 million people worldwide, and it is estimated that in 2050 more than 100 million will be…

Multimedia · Computer Science 2021-01-20 Mariona Caros , Maite Garolera , Petia Radeva , Xavier Giro-i-Nieto

Alzheimer's disease (AD) leads to progressive cognitive decline, making early detection crucial for effective intervention. While deep learning models have shown high accuracy in AD diagnosis, their lack of interpretability limits clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Yasmine Mustafa , Mohamed Elmahallawy , Tie Luo

Alzheimer's disease and Frontotemporal dementia are common types of neurodegenerative disorders that present overlapping clinical symptoms, making their differential diagnosis very challenging. Numerous efforts have been done for the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé
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