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The capability of reliably detecting out-of-distribution samples is one of the key factors in deploying a good classifier, as the test distribution always does not match with the training distribution in most real-world applications. In…

Machine Learning · Computer Science 2021-04-05 Dongha Lee , Sehun Yu , Hwanjo Yu

Reliable quantification of epistemic and aleatoric uncertainty is of crucial importance in applications where models are trained in one environment but applied to multiple different environments, often seen in real-world applications for…

Machine Learning · Computer Science 2023-11-02 Simon Dirmeier , Ye Hong , Yanan Xin , Fernando Perez-Cruz

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Today, deep learning is increasingly applied in security-critical situations such as autonomous driving and medical diagnosis. Despite its success, the behavior and robustness of deep networks are not fully understood yet, posing a…

Machine Learning · Computer Science 2023-03-27 Sven Elflein

The ability to detect Out-of-Distribution (OOD) data is important in safety-critical applications of deep learning. The aim is to separate In-Distribution (ID) data drawn from the training distribution from OOD data using a measure of…

Machine Learning · Computer Science 2022-09-21 Guoxuan Xia , Christos-Savvas Bouganis

The growing reliance on Artificial Intelligence (AI) in critical domains such as healthcare demands robust mechanisms to ensure the trustworthiness of these systems, especially when faced with unexpected or anomalous inputs. This paper…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Max Gutbrod , David Rauber , Danilo Weber Nunes , Christoph Palm

There is an increasingly apparent need for validating the classifications made by deep learning systems in safety-critical applications like autonomous vehicle systems. A number of recent papers have proposed methods for detecting anomalous…

Machine Learning · Computer Science 2018-12-10 Taylor Denouden , Rick Salay , Krzysztof Czarnecki , Vahdat Abdelzad , Buu Phan , Sachin Vernekar

It is crucial to detect when an instance lies downright too far from the training samples for the machine learning model to be trusted, a challenge known as out-of-distribution (OOD) detection. For neural networks, one approach to this task…

More than 10.7% of people aged 65 and older are affected by Alzheimer's disease. Early diagnosis and treatment are crucial as most Alzheimer's patients are unaware of having it until the effects become detrimental. AI has been known to use…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Audrey Paleczny , Shubham Parab , Maxwell Zhang

Deep learning (DL)-based systems can exhibit unexpected behavior when exposed to out-of-distribution (OOD) scenarios, posing serious risks in safety-critical domains such as malware detection and autonomous driving. This underscores the…

Software Engineering · Computer Science 2026-04-28 Jingyu Zhang , Fan Wang , Jacky Keung , Yihan Liao , Yan Xiao , Lei Ma

For machine learning systems to be reliable, we must understand their performance in unseen, out-of-distribution environments. In this paper, we empirically show that out-of-distribution performance is strongly correlated with…

When presented with Out-of-Distribution (OOD) examples, deep neural networks yield confident, incorrect predictions. Detecting OOD examples is challenging, and the potential risks are high. In this paper, we propose to detect OOD examples…

Machine Learning · Computer Science 2020-01-10 Chandramouli Shama Sastry , Sageev Oore

As input data distributions evolve, the predictive performance of machine learning models tends to deteriorate. In practice, new input data tend to come without target labels. Then, state-of-the-art techniques model input data distributions…

Machine Learning · Computer Science 2023-09-08 Carlos Mougan , Klaus Broelemann , David Masip , Gjergji Kasneci , Thanassis Thiropanis , Steffen Staab

Out-of-Distribution (OoD) detection aims to justify whether a given sample is from the training distribution of the classifier-under-protection, i.e., In-Distribution (InD), or from OoD. Diffusion Models (DMs) are recently utilized in OoD…

Computer Vision and Pattern Recognition · Computer Science 2024-11-20 Kun Fang , Qinghua Tao , Zuopeng Yang , Xiaolin Huang , Jie Yang

Recent years have witnessed significant progress in the development of machine learning models across a wide range of fields, fueled by increased computational resources, large-scale datasets, and the rise of deep learning architectures.…

To deploy and operate deep neural models in production, the quality of their predictions, which might be contaminated benignly or manipulated maliciously by input distributional deviations, must be monitored and assessed. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2023-06-09 Guy Bar-Shalom , Yonatan Geifman , Ran El-Yaniv

Medical Image Analysis (MedIA) has become indispensable in modern healthcare, enhancing clinical diagnostics and personalized treatment. Despite the remarkable advancements supported by deep learning (DL) technologies, their practical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Zixian Su , Jingwei Guo , Xi Yang , Qiufeng Wang , Frans Coenen , Amir Hussain , Kaizhu Huang

Deep neural network, despite its remarkable capability of discriminating targeted in-distribution samples, shows poor performance on detecting anomalous out-of-distribution data. To address this defect, state-of-the-art solutions choose to…

Computer Vision and Pattern Recognition · Computer Science 2022-08-30 Boxi Wu , Jie Jiang , Haidong Ren , Zifan Du , Wenxiao Wang , Zhifeng Li , Deng Cai , Xiaofei He , Binbin Lin , Wei Liu

Deep learning-based models are developed to automatically detect if a retina image is `referable' in diabetic retinopathy (DR) screening. However, their classification accuracy degrades as the input images distributionally shift from their…

Computer Vision and Pattern Recognition · Computer Science 2021-07-27 Jay Nandy , Wynne Hsu , Mong Li Lee

Models trained with deep learning often fail to signal when inputs fall outside their training data manifold, leading to unreliable predictions under distribution shift. Prior work suggests that effective out-of-distribution (OOD) detection…

Machine Learning · Computer Science 2026-05-08 Brett Barkley , Preston Culbertson , David Fridovich-Keil