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Recent advances in deep learning have led to breakthroughs in the development of automated skin disease classification. As we observe an increasing interest in these models in the dermatology space, it is crucial to address aspects such as…

Computer Vision and Pattern Recognition · Computer Science 2021-06-03 Hannah Kim , Girmaw Abebe Tadesse , Celia Cintas , Skyler Speakman , Kush Varshney

Machine Learning (ML) models have gained popularity in medical imaging analysis given their expert level performance in many medical domains. To enhance the trustworthiness, acceptance, and regulatory compliance of medical imaging models…

Human-Computer Interaction · Computer Science 2025-06-06 Mischa Dombrowski , Andrea Prenner , Bernhard Kainz

In computational histopathology algorithms now outperform humans on a range of tasks, but to date none are employed for automated diagnoses in the clinic. Before algorithms can be involved in such high-stakes decisions they need to "know…

Computer Vision and Pattern Recognition · Computer Science 2022-10-19 Lea Goetz

We consider robustness to distribution shifts in the context of diagnostic models in healthcare, where the prediction target $Y$, e.g., the presence of a disease, is causally upstream of the observations $X$, e.g., a biomarker. Distribution…

Machine learning models deployed on medical imaging tasks must be equipped with out-of-distribution detection capabilities in order to avoid erroneous predictions. It is unsure whether out-of-distribution detection models reliant on deep…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Sebastian G. Popescu , David J. Sharp , James H. Cole , Konstantinos Kamnitsas , Ben Glocker

The automatic detection of skin diseases via dermoscopic images can improve the efficiency in diagnosis and help doctors make more accurate judgments. However, conventional skin disease recognition systems may produce high confidence for…

Computer Vision and Pattern Recognition · Computer Science 2023-01-19 Zhongzheng Huang , Tao Wang , Yuanzheng Cai , Lingyu Liang

Detection of Out-of-Distribution (OOD) samples in real time is a crucial safety check for deployment of machine learning models in the medical field. Despite a growing number of uncertainty quantification techniques, there is a lack of…

Machine Learning · Computer Science 2022-05-09 Karina Zadorozhny , Patrick Thoral , Paul Elbers , Giovanni Cinà

Deep neural networks often suffer from overconfidence which can be partly remedied by improved out-of-distribution detection. For this purpose, we propose a novel approach that allows for the generation of out-of-distribution datasets based…

Machine Learning · Computer Science 2021-05-10 Felix Möller , Diego Botache , Denis Huseljic , Florian Heidecker , Maarten Bieshaar , Bernhard Sick

Distributional shift, or the mismatch between training and deployment data, is a significant obstacle to the usage of machine learning in high-stakes industrial applications, such as autonomous driving and medicine. This creates a need to…

The recent achievements of Deep Learning rely on the test data being similar in distribution to the training data. In an ideal case, Deep Learning models would achieve Out-of-Distribution (OoD) Generalization, i.e. reliably make predictions…

Image and Video Processing · Electrical Eng. & Systems 2021-09-07 Antoine Sanner , Camila Gonzalez , Anirban Mukhopadhyay

Deep neural networks have shown promising results in disease detection and classification using medical image data. However, they still suffer from the challenges of handling real-world scenarios especially reliably detecting…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Muhammad Zaida , Shafaqat Ali , Mohsen Ali , Sarfaraz Hussein , Asma Saadia , Waqas Sultani

The use of neural networks has been very successful in a wide variety of applications. However, it has recently been observed that it is difficult to generalize the performance of neural networks under the condition of distributional shift.…

Computational Finance · Quantitative Finance 2022-09-20 Dangxing Chen

A trained ML model is deployed on another `test' dataset where target feature values (labels) are unknown. Drift is distribution change between the training and deployment data, which is concerning if model performance changes. For a…

Applications · Statistics 2022-09-07 Samuel Ackerman , Eitan Farchi , Orna Raz , Marcel Zalmanovici , Parijat Dube

The increased success of Deep Learning (DL) has recently sparked large-scale deployment of DL models in many diverse industry segments. Yet, a crucial weakness of supervised model is the inherent difficulty in handling out-of-distribution…

Machine Learning · Computer Science 2021-07-15 Lixuan Yang , Dario Rossi

Convolutional neural networks applied for real-world classification tasks need to recognize inputs that are far or out-of-distribution (OoD) with respect to the known or training data. To achieve this, many methods estimate…

Machine Learning · Computer Science 2021-10-18 Kamil Szyc , Tomasz Walkowiak , Henryk Maciejewski

Numerous machine learning (ML) models have been developed, including those for software engineering (SE) tasks, under the assumption that training and testing data come from the same distribution. However, training and testing distributions…

Software Engineering · Computer Science 2025-03-04 Yanfu Yan , Viet Duong , Huajie Shao , Denys Poshyvanyk

In the real world, a learning system could receive an input that is unlike anything it has seen during training. Unfortunately, out-of-distribution samples can lead to unpredictable behaviour. We need to know whether any given input belongs…

Machine Learning · Computer Science 2019-08-21 Alireza Shafaei , Mark Schmidt , James J. Little

Out-of-distribution detection is crucial to the safe deployment of machine learning systems. Currently, unsupervised out-of-distribution detection is dominated by generative-based approaches that make use of estimates of the likelihood or…

Safe deployment of machine learning (ML) models in safety-critical domains such as medical imaging requires detecting inputs with characteristics not seen during training, known as out-of-distribution (OOD) detection, to prevent unreliable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Felix Wagner , Pramit Saha , Harry Anthony , J. Alison Noble , Konstantinos Kamnitsas

Cyber-physical systems (CPS) greatly benefit by using machine learning components that can handle the uncertainty and variability of the real-world. Typical components such as deep neural networks, however, introduce new types of hazards…

Machine Learning · Computer Science 2020-01-29 Feiyang Cai , Xenofon Koutsoukos