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Related papers: Concentration Robustness in LP Kinetic Systems

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There have been recent theoretic results that provide sufficient conditions for the existence of a species displaying absolute concentration robustness (ACR) in a power law kinetic (PLK) system. One such result involves the detection of ACR…

Chemical Physics · Physics 2020-11-06 Lauro L. Fontanil , Eduardo R. Mendoza , Noel T. Fortun

This work introduces a novel approach to study properties of positive equilibria of a chemical reaction network $\mathscr{N}$ endowed with Hill-type kinetics $K$, called a Hill-type kinetic (HTK) system $\left(\mathscr{N},K\right)$,…

Dynamical Systems · Mathematics 2020-09-08 Bryan S. Hernandez , Eduardo R. Mendoza

Studies about the set of positive equilibria ($E_+$) of kinetic systems have been focused on mass action, and not that much on power law kinetic (PLK) systems, even for PL-RDK systems (PLK systems where two reactions with identical reactant…

Dynamical Systems · Mathematics 2022-04-06 Bryan S. Hernandez , Eduardo R. Mendoza

Robustness against the presence of environmental disruptions can be observed in many systems of chemical reaction network. However, identifying the underlying components of a system that give rise to robustness is often elusive. The…

Dynamical Systems · Mathematics 2020-03-31 Noel T. Fortun , Angelyn R. Lao , Luis F. Razon , Eduardo R. Mendoza

A complex balanced kinetic system is absolutely complex balanced (ACB) if every positive equilibrium is complex balanced. Two results on absolute complex balancing were foundational for modern chemical reaction network theory (CRNT): in…

Dynamical Systems · Mathematics 2021-12-28 Editha C. Jose , Eduardo R. Mendoza , Dylan Antonio SJ. Talabis

Poly-PL kinetic systems (PYK) are kinetic systems consisting of nonnegative linear combinations of power law functions. In this contribution, we analyze these kinetic systems using two main approaches: (1) we define a canonical power law…

Dynamical Systems · Mathematics 2021-12-24 Editha C. Jose , Eduardo R. Mendoza , Dylan Antonio SJ. Talabis

A kinetic system has an absolute concentration robustness (ACR) for a molecular species if its concentration remains the same in every positive steady state of the system. Just recently, a condition that sufficiently guarantees the…

Dynamical Systems · Mathematics 2023-04-10 Eduardo R. Mendoza , Dylan Antonio SJ. Talabis , Editha C. Jose , Lauro L. Fontanil

A reaction system exhibits "absolute concentration robustness" (ACR) in some species if the positive steady-state value of that species does not depend on initial conditions. Mathematically, this means that the positive part of the variety…

Dynamical Systems · Mathematics 2022-06-08 Nicolette Meshkat , Anne Shiu , Angélica Torres

Poly-PL kinetic systems are kinetic systems consisting of nonnegative linear combinations of power law functions. In this contribution, we analyze these kinetic systems using two main approaches: (1) we define a canonical power law…

Dynamical Systems · Mathematics 2021-07-13 Noel T. Fortun , Dylan Antonio SJ. Talabis , Editha C. Jose , Eduardo R. Mendoza

Absolute concentration robustness (ACR) is a condition wherein a species in a chemical kinetic system possesses the same value for any positive steady state the network may admit regardless of initial conditions. Thus far, results on ACR…

Dynamical Systems · Mathematics 2020-04-02 Noel T. Fortun , Eduardo R. Mendoza

One important question that interests those who work in chemical reaction network theory (CRNT) is this: Does the system obtained from a reaction network admit a positive equilibrium and if it does, can there be more than one within a…

Biochemical systems that express certain chemical species of interest at the same level at any positive equilibrium are called "absolute concentration robust" (ACR). These species behave in a stable, predictable way, in the sense that their…

Subcellular Processes · Quantitative Biology 2019-10-15 Daniele Cappelletti , Ankit Gupta , Mustafa Khammash

This paper presents a computational solution to determine if a chemical reaction network endowed with power-law kinetics (PLK system) has the capacity for multistationarity, i.e., whether there exist positive rate constants such that the…

Dynamical Systems · Mathematics 2020-02-19 Bryan S. Hernandez , Eduardo R. Mendoza , Aurelio A. de los Reyes

Many reaction networks arising in applications are multistationary, that is, they have the capacity for more than one steady state; while some networks exhibit absolute concentration robustness (ACR), which means that some species…

Dynamical Systems · Mathematics 2024-11-20 Nidhi Kaihnsa , Tung Nguyen , Anne Shiu

Absolute Concentration Robustness (ACR) was introduced by Shinar and Feinberg as robustness of equilibrium species concentration in a mass action dynamical system. Their aim was to devise a mathematical condition that will ensure robustness…

Dynamical Systems · Mathematics 2022-11-16 Badal Joshi , Gheorghe Craciun

Biological and advanced cyberphysical control systems often have limited, sparse, uncertain, and distributed communication and computing in addition to sensing and actuation. Fortunately, the corresponding plants and performance…

Systems and Control · Electrical Eng. & Systems 2019-07-08 Yuh-Shyang Wang , Nikolai Matni , John C. Doyle

Networks with absolute concentration robustness (ACR) have the property that a translation of a coordinate hyperplane either contains all steady states (static ACR) or attracts all trajectories (dynamic ACR). The implication for the…

Dynamical Systems · Mathematics 2022-06-22 Badal Joshi , Gheorghe Craciun

Motivation: Stochastic reaction networks are a widespread model to describe biological systems where the presence of noise is relevant, such as in cell regulatory processes. Unfortu-nately, in all but simplest models the resulting discrete…

Quantitative Methods · Quantitative Biology 2021-01-12 Luca Cardelli , Isabel Cristina Perez-Verona , Mirco Tribastone , Max Tschaikowski , Andrea Vandin , Tabea Waizmann

We present an approach to identify a quasi Linear Parameter Varying (qLPV) model of a plant, with the qLPV model guaranteed to admit a robust control invariant (RCI) set. It builds upon the concurrent synthesis framework presented in [1],…

Optimization and Control · Mathematics 2025-05-13 Sampath Kumar Mulagaleti , Alberto Bemporad

Recent research in both the experimental and mathematical communities has focused on biochemical interaction systems that satisfy an "absolute concentration robustness" (ACR) property. The ACR property was first discovered experimentally…

Probability · Mathematics 2018-05-22 David F. Anderson , Daniele Cappelletti , Thomas G. Kurtz
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