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Objective: Identifying the activity of motor neurons (MNs) non-invasively is possible by decomposing signals from muscles, e.g., surface electromyography (EMG) or ultrasound. The theoretical background of MN identification is convolutive…

Quantitative Methods · Quantitative Biology 2025-08-19 Thomas Klotz , Robin Rohlén

Accurate fMRI analysis requires sensitivity to temporal structure across multiple scales, as BOLD signals encode cognitive processes that emerge from fast transient dynamics to slower, large-scale fluctuations. Existing deep learning (DL)…

Signal Processing · Electrical Eng. & Systems 2026-01-06 Furkan Genç , Boran İsmet Macun , Sait Sarper Özaslan , Emine U. Saritas , Tolga Çukur

Following limb amputation and targeted muscle reinnervation (TMR), nerves that originally innervated agonist and antagonist muscles are rerouted into one or more residual target muscles. This rerouting profoundly alters the natural…

Neurons and Cognition · Quantitative Biology 2026-02-19 Laura Ferrante , Anna Boesendorfer , Benedikt Baumgartner , Manuel Catalano , Antonio Bicchi , Oskar Aszmann , Dario Farina

Deep Brain Stimulation (DBS) is a therapy widely used for treating the symptoms of neurological disorders. Electrical pulses are chronically delivered in DBS to a disease-specific brain target via a surgically implanted electrode. The…

Systems and Control · Electrical Eng. & Systems 2024-10-24 Anna Franziska Frigge , Elena Jiltsova , Fredrik Olsson , Dag Nyholm , Alexander Medvedev

Teleoperated robot-assisted minimally-invasive surgery (RAMIS) offers many advantages over open surgery. However, there are still no guidelines for training skills in RAMIS. Motor learning theories have the potential to improve the design…

Robotics · Computer Science 2021-05-11 Yarden Sharon , Daniel Naftalovich , Lidor Bahar , Yael Refaely , Ilana Nisky

Non-invasive brain-computer interfaces help the subjects to control external devices by brain intentions. The multi-class classification of upper limb movements can provide external devices with more control commands. The onsets of the…

Human-Computer Interaction · Computer Science 2022-12-20 Hao Jia , Feng Duan , Yu Zhang , Zhe Sun , Jordi Sole-Casals

Background: Cognitive impairment in multiple sclerosis (MS) is driven by both focal inflammation and compartmentalized neurodegeneration, yet the relative effect of lesion-independent thalamic atrophy on information processing speed (IPS)…

Neurons and Cognition · Quantitative Biology 2026-02-19 Arshya Pooladi-Darvish , Heather Rosehart , Marina R. Everest , Ali R. Khan , Sarah A. Morrow

Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical…

There has been a long history in electrical muscle stimulation (EMS), which has been used for medical and interaction purposes. Human-computer interaction (HCI) researchers are now working on various applications, including virtual reality…

Human-Computer Interaction · Computer Science 2019-02-11 Michinari Kono , Jun Rekimoto

We propose a novel dual-loop system that synergistically combines responsive neurostimulation (RNS) implants with artificial intelligence-driven wearable devices for treating post-traumatic stress disorder (PTSD) and enabling naturalistic…

Neurons and Cognition · Quantitative Biology 2025-03-25 Edward Hong Wang , Cynthia Xin Wen

Temporal Interference Stimulation (TIS) is a non-invasive neuromodulation technique in which two high-frequency sinusoidal currents with slightly different frequencies generate a low-frequency envelope that can activate deep neural…

Dynamical Systems · Mathematics 2026-05-19 Esteban Paduro , Antoine Chaillet , Mario Sigalotti

Tendon-sheath mechanisms (TSMs) are widely used in minimally invasive surgical (MIS) applications, but their inherent hysteresis-caused by friction, backlash, and tendon elongation-leads to significant tracking errors. Conventional modeling…

Robotics · Computer Science 2025-03-05 Myeongbo Park , Chunggil An , Junhyun Park , Jonghyun Kang , Minho Hwang

Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…

Neurons and Cognition · Quantitative Biology 2011-05-09 Paul Expert , Renaud Lambiotte , Dante R. Chialvo , Kim Christensen , Henrik Jeldtoft Jensen , David J. Sharp , Federico Turkheimer

In this work, the effects of dopamine neurotransmitter within the Cortico-Striatal-Thalamo-Cortical (CSTC) loop have been investigated. Simulations confirmed dopamine facilitates movement via thalamic disinhibition. Analysis of its impact…

Neurons and Cognition · Quantitative Biology 2025-11-26 Hadi Barati , Ali Nayerifar , Mehdi Fardmanesh

Deep Brain Stimulation (DBS) is a highly effective treatment for Parkinson's Disease (PD). Recent research uses reinforcement learning (RL) for DBS, with RL agents modulating the stimulation frequency and amplitude. But, these models rely…

Machine Learning · Computer Science 2025-10-07 Nicholas Carter , Arkaprava Gupta , Prateek Ganguli , Benedikt Dietrich , Vibhor Krishna , Samarjit Chakraborty

In recent years, network analyses have been used to evaluate brain reorganization following stroke. However, many studies have often focused on single topological scales, leading to an incomplete model of how focal brain lesions affect…

Neurons and Cognition · Quantitative Biology 2014-09-10 Fabrizio De Vico Fallani , Floriana Pichiorri , Giovanni Morone , Marco Molinari , Fabio Babiloni , Febo Cincotti , Donatella Mattia

Functional Magnetic Resonance Imaging (fMRI) maps cerebral activation in response to stimuli but this activation is often difficult to detect, especially in low-signal contexts and single-subject studies. Accurate activation detection can…

Applications · Statistics 2023-10-26 Wei-Chen Chen , Ranjan Maitra

We present a new statistical method to analyze multichannel steady-state local field potentials (LFP) recorded within different sensory cortices of different rodent species. Our spatiotemporal multi-dimensional cluster statistics (MCS)…

Quantitative Methods · Quantitative Biology 2016-11-24 Patrick Krauss , Claus Metzner , Achim Schilling , Konstantin Tziridis , Maximilian Traxdorf , Holger Schulze

Demographic shifts have led to an increase in mild cognitive impairment (MCI), and this study investigates the effects of cognitive training (CT) and reminiscence therapy (RT) conducted by humans or socially assistive robots (SARs) on…

Muscle activation initiates contractions that drive human movement, and understanding it provides valuable insights for injury prevention and rehabilitation. Yet, sensing muscle activation is barely explored in the rapidly growing mobile…

Human-Computer Interaction · Computer Science 2026-02-12 Hao Zhou , Mahanth Gowda
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