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Accurate diagnostic tests are essential for effective screening and treatment. However, individual biomarkers often fail to provide sufficient diagnostic accuracy, as they typically capture only one aspect of the complex disease process.…

Methodology · Statistics 2025-07-08 Ainesh Sewak , Sandra Siegfried , Torsten Hothorn

In real-world clinical practice, electrocardiograms (ECGs) are often captured and shared as photographs. However, publicly available ECG data, and thus most related research, relies on digital signals. This has led to a disconnect in which…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Xiaoyu Wang , Ramesh Nadarajah , Zhiqiang Zhang , David Wong

In the era of large models, content generation is gradually shifting to Personalized Generation (PGen), tailoring content to individual preferences and needs. This paper presents the first comprehensive survey on PGen, investigating…

Information Retrieval · Computer Science 2025-06-03 Yiyan Xu , Jinghao Zhang , Alireza Salemi , Xinting Hu , Wenjie Wang , Fuli Feng , Hamed Zamani , Xiangnan He , Tat-Seng Chua

Microscopic examination of slides prepared from tissue samples is the primary tool for detecting and classifying cancerous lesions, a process that is time-consuming and requires the expertise of experienced pathologists. Recent advances in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Saba Fatema , Brighton Nuwagira , Sayoni Chakraborty , Reyhan Gedik , Baris Coskunuzer

The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. However, most prognostic models are either based on histology or…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 Richard J. Chen , Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Jana Lipkova , Muhammad Shaban , Maha Shady , Mane Williams , Bumjin Joo , Zahra Noor , Faisal Mahmood

Alterations in nuclear morphology are useful adjuncts and even diagnostic tools used by pathologists in the diagnosis and grading of many tumors, particularly malignant tumors. Large datasets such as TCGA and the Human Protein Atlas, in…

Quantitative Methods · Quantitative Biology 2023-02-06 Mohammad Shifat E Rabbi , Natasha Ironside , John A Ozolek , Rajendra Singh , Liron Pantanowitz , Gustavo K Rohde

Probabilistic atlases provide essential spatial contextual information for image interpretation, Bayesian modeling, and algorithmic processing. Such atlases are typically constructed by grouping subjects with similar demographic…

Machine Learning · Computer Science 2018-06-07 Yuankai Huo , Katherine Swett , Susan M. Resnick , Laurie E. Cutting , Bennett A. Landman

It is increasingly common clinically for cancer specimens to be examined using techniques that identify somatic mutations. In principle these mutational profiles can be used to diagnose the tissue of origin, a critical task for the 3-5% of…

Methodology · Statistics 2020-07-14 Saptarshi Chakraborty , Colin B. Begg , Ronglai Shen

More than 144 000 Australians were diagnosed with cancer in 2019. The majority will first present to their GP symptomatically, even for cancer for which screening programs exist. Diagnosing cancer in primary care is challenging due to the…

Machine Learning · Computer Science 2020-12-21 Goce Ristanoski , Jon Emery , Javiera Martinez-Gutierrez , Damien Mccarthy , Uwe Aickelin

Multi-modal data comprising imaging (MRI, fMRI, PET, etc.) and non-imaging (clinical test, demographics, etc.) data can be collected together and used for disease prediction. Such diverse data gives complementary information about the…

Machine Learning · Computer Science 2018-12-27 Anees Kazi , S. Arvind krishna , Shayan Shekarforoush , Karsten Kortuem , Shadi Albarqouni , Nassir Navab

Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

Methodology · Statistics 2018-05-07 Bochao Jia

Lung cancer is a condition where there is abnormal growth of malignant cells that spread in an uncontrollable fashion in the lungs. Some common treatment strategies are surgery, chemotherapy, and radiation which aren't the best options due…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Ann Rachel , Pranav M Pawar , Mithun Mukharjee , Raja M , Tojo Mathew

Personalized models are essential in digital health because individuals exhibit substantial physiological and behavioral heterogeneity. Yet personalization is limited by scarce and noisy user-specific data. Most existing methods rely on…

Artificial Intelligence · Computer Science 2026-05-15 Zhongqi Yang , Mahkameh Rasouli , Neda Mohseni , Yong Huang , Iman Azimi , Amir M. Rahmani

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Clinical research often focuses on complex traits in which many variables play a role in mechanisms driving, or curing, diseases. Clinical prediction is hard when data is high-dimensional, but additional information, like domain knowledge…

Methodology · Statistics 2020-05-21 Mirrelijn M. van Nee , Lodewyk F. A. Wessels , Mark A. van de Wiel

Since technology is advancing so quickly in the modern era of information, data is becoming an essential resource in many fields. Correct data collection, organization, and analysis make it a potent tool for successful decision-making,…

Machine Learning · Computer Science 2024-05-28 Dilsat Berin Aytar , Semra Gunduc

Tumor heterogeneity is a challenge to designing effective and targeted therapies. Glioma-type identification depends on specific molecular and histological features, which are defined by the official WHO classification CNS. These guidelines…

Applications · Statistics 2023-05-23 Roberta Coletti , Mónica L. Mendonça , Susana Vinga , Marta B. Lopes

Despite the progress of radiology report generation (RRG), existing works face two challenges: 1) The performances in clinical efficacy are unsatisfactory, especially for lesion attributes description; 2) the generated text lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Haibo Jin , Haoxuan Che , Sunan He , Hao Chen

Survival prediction is a complex ordinal regression task that aims to predict the survival coefficient ranking among a cohort of patients, typically achieved by analyzing patients' whole slide images. Existing deep learning approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-05-01 Minghao Han , Xukun Zhang , Dingkang Yang , Tao Liu , Haopeng Kuang , Jinghui Feng , Lihua Zhang

Synthetic tabular data is increasingly used in privacy-sensitive domains such as health care, but existing generative models often fail to preserve inter-attribute relationships. In particular, functional dependencies (FDs) and logical…

Machine Learning · Computer Science 2025-07-28 Chaithra Umesh , Kristian Schultz , Manjunath Mahendra , Saptarshi Bej , Olaf Wolkenhauer
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