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Reducing the computational time required by high-fidelity, full order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. While FOMs,…

Numerical Analysis · Mathematics 2022-02-09 Ludovica Cicci , Stefania Fresca , Andrea Manzoni , Alfio Quarteroni

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the formulation and numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential,…

Computational Physics · Physics 2021-01-27 Stefania Fresca , Andrea Manzoni , Luca Dedè , Alfio Quarteroni

In this work a machine learning-based Reduced Order Model (ROM) is developed to investigate in a rapid and reliable way the hemodynamic patterns in a patient-specific configuration of Coronary Artery Bypass Graft (CABG). The computational…

Numerical Analysis · Mathematics 2022-03-31 Pierfrancesco Siena , Michele Girfoglio , Gianluigi Rozza

Cardio-mechanical models can be used to support clinical decision-making. Unfortunately, the substantial computational effort involved in many cardiac models hinders their application in the clinic, despite the fact that they may provide…

Computational Engineering, Finance, and Science · Computer Science 2026-05-19 Robin Willems , Peter Förster , Sebastian Schöps , Olaf van der Sluis , Clemens V. Verhoosel

The complexity of the cardiovascular system needs to be accurately reproduced in order to promptly acknowledge health conditions; to this aim, advanced multifidelity and multiphysics numerical models are crucial. On one side, Full Order…

Reduced-order models (ROMs) allow for the simulation of blood flow in patient-specific vasculatures without the high computational cost and wait time associated with traditional computational fluid dynamics (CFD) models. Unfortunately, due…

Computational Engineering, Finance, and Science · Computer Science 2024-02-27 Natalia L. Rubio , Luca Pegolotti , Martin R. Pfaller , Eric F. Darve , Alison L. Marsden

In this work the development of a machine learning-based Reduced Order Model (ROM) for the investigation of hemodynamics in a patient-specific configuration of Coronary Artery Bypass Graft (CABG) is proposed. The computational domain is…

Medical Physics · Physics 2023-08-08 Pierfrancesco Siena , Michele Girfoglio , Francesco Ballarin , Gianluigi Rozza

Reduced Order Models (ROMs) form essential tools across engineering domains by virtue of their function as surrogates for computationally intensive digital twinning simulators. Although purely data-driven methods are available for ROM…

Computational Engineering, Finance, and Science · Computer Science 2025-04-14 Konstantinos Vlachas , Thomas Simpson , Anthony Garland , D. Dane Quinn , Charbel Farhat , Eleni Chatzi

This paper deals with the development of a Reduced-Order Model (ROM) to investigate haemodynamics in cardiovascular applications. It employs the use of Proper Orthogonal Decomposition (POD) for the computation of the basis functions and the…

Numerical Analysis · Mathematics 2025-01-24 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

The Model Order Reduction (MOR) technique can provide compact numerical models for fast simulation. Different from the intrusive MOR methods, the non-intrusive MOR does not require access to the Full Order Models (FOMs), especially system…

Machine Learning · Computer Science 2022-04-20 Qinyu Zhuang , Dirk Hartmann , Hans Joachim Bungartz , Juan Manuel Lorenzi

This paper focuses on reduced-order models (ROMs) built for the efficient treatment of PDEs having solutions that bifurcate as the values of multiple input parameters change. First, we consider a method called local ROM that uses k-means…

Numerical Analysis · Mathematics 2022-01-03 Martin W. Hess , Annalisa Quaini , Gianluigi Rozza

Reduced order modeling (ROM) is a field of techniques that approximates complex physics-based models of real-world processes by inexpensive surrogates that capture important dynamical characteristics with a smaller number of degrees of…

Machine Learning · Computer Science 2021-08-30 Rachel Cooper , Andrey A. Popov , Adrian Sandu

Cardiovascular diseases are a leading cause of death in the world, driving the development of patient-specific and benchmark models for blood flow analysis. This chapter provides a theoretical overview of the main categories of Reduced…

Numerical Analysis · Mathematics 2025-10-21 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

The basis generation in reduced order modeling usually requires multiple high-fidelity large-scale simulations that could take a huge computational cost. In order to accelerate these numerical simulations, we introduce a FOM/ROM hybrid…

Numerical Analysis · Mathematics 2021-03-17 Lihong Feng , Guosheng Fu , Zhu Wang

Reduced order modeling (ROM) techniques are numerical methods that approximate the solution of parametric partial differential equation (PDE) by properly combining the high-fidelity solutions of the problem obtained for several…

Numerical Analysis · Mathematics 2023-08-08 M. Girfoglio , L. Scandurra , F. Ballarin , G. Infantino , F. Nicolò , A. Montalto , G. Rozza , R. Scrofani , M. Comisso , F. Musumeci

One predominant challenge in additive manufacturing (AM) is to achieve specific material properties by manipulating manufacturing process parameters during the runtime. Such manipulation tends to increase the computational load imposed on…

Machine Learning · Computer Science 2023-10-24 Mahmoud Yaseen , Dewen Yushu , Peter German , Xu Wu

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

Time-dependent partial differential equations are ubiquitous in physics-based modeling, but they remain computationally intensive in many-query scenarios, such as real-time forecasting, optimal control, and uncertainty quantification.…

Machine Learning · Computer Science 2026-01-26 Sven Dummer , Dongwei Ye , Christoph Brune

Reduced Order Modelling (ROM) has been widely used to create lower order, computationally inexpensive representations of higher-order dynamical systems. Using these representations, ROMs can efficiently model flow fields while using…

Fluid Dynamics · Physics 2021-10-13 Pranshu Pant , Ruchit Doshi , Pranav Bahl , Amir Barati Farimani

Simulating fluid flows in different virtual scenarios is of key importance in engineering applications. However, high-fidelity, full-order models relying, e.g., on the finite element method, are unaffordable whenever fluid flows must be…

Fluid Dynamics · Physics 2021-11-24 Stefania Fresca , Andrea Manzoni
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