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Coarse-grained modeling and efficient computer simulations are critical to the study of complex molecular processes with many degrees of freedom and multiple spatiotemporal scales. Variational implicit-solvent model (VISM) for biomolecular…

Chemical Physics · Physics 2022-10-26 Shuang Liu , Zirui Zhang , Li-Tien Cheng , Bo Li

A level-set method is developed for numerically capturing the equilibrium solute-solvent interface that is defined by the recently proposed variational implicit solvent model (Dzubiella, Swanson, and McCammon, Phys. Rev. Lett. {\bf 104},…

Chemical Physics · Physics 2009-11-13 L. -T. Cheng , J. Dzubiella , J. A. McCammon , B. Li

In the past decade, variational implicit solvation models (VISM) have achieved great success in solvation energy predictions. However, all existing VISMs in literature lack the uniqueness of an energy minimizing solute-solvent interface and…

Analysis of PDEs · Mathematics 2022-03-23 Zhan Chen , Yuanzhen Shao

Score matching (SM) provides a compelling approach to learn energy-based models (EBMs) by avoiding the calculation of partition function. However, it remains largely open to learn energy-based latent variable models (EBLVMs), except some…

Machine Learning · Computer Science 2020-10-19 Fan Bao , Chongxuan Li , Kun Xu , Hang Su , Jun Zhu , Bo Zhang

The multi-level method for discrete state systems, first introduced by Anderson and Higham [Multiscale Model. Simul. 10:146--179, 2012], is a highly efficient simulation technique that can be used to elucidate statistical characteristics of…

Quantitative Methods · Quantitative Biology 2016-09-06 Christopher Lester , Ruth E. Baker , Michael B. Giles , Christian A. Yates

The structure and function of biological molecules are strongly influenced by the water and dissolved ions that surround them. This aqueous solution (solvent) exerts significant electrostatic forces in response to the biomolecule's…

Numerical Analysis · Mathematics 2015-12-29 Matthew G. Knepley , Jaydeep P. Bardhan

Solid-liquid interfaces are at the heart of many modern-day technologies and provide a challenge to many materials simulation methods. A realistic first-principles computational study of such systems entails the inclusion of solvent…

Bilevel programs (BPs) find a wide range of applications in fields such as energy, transportation, and machine learning. As compared to BPs with continuous (linear/convex) optimization problems in both levels, the BPs with discrete decision…

Optimization and Control · Mathematics 2024-07-25 Bo Zhou , Ruiwei Jiang , Siqian Shen

The dynamics of solid-liquid interfaces controlled by solute precipitation and/or dissolution due to the chemical reaction at the interface were computed in two dimensions using a phase field models. Sharp-interface asymptotic analysis…

Computational Physics · Physics 2018-08-30 Zhijie Xu , Hai Huang , Xiaoyi Li , Paul Meakin

The level set method is a widely used tool for solving reachability and invariance problems. However, some shortcomings, such as the difficulties of handling dissipation function and constructing terminal conditions for solving the…

Systems and Control · Electrical Eng. & Systems 2021-12-01 Wei Liao , Taotao Liang , Xiaohui Wei , Jizhou Lai

Variational level set method has become a powerful tool in image segmentation due to its ability to handle complex topological changes and maintain continuity and smoothness in the process of evolution. However its evolution process can be…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Fanghui Song , Jiebao Sun , Shengzhu Shi , Zhichang Guo , Dazhi Zhang

The boundary element method (BEM) provides an efficient numerical framework for solving multiple scattering problems in unbounded homogeneous domains, since it reduces the discretization to the domain boundaries, thereby condensing the…

Machine Learning · Computer Science 2025-12-03 Rémi Marsal , Stéphanie Chaillat

Implicit solvent models, such as Poisson-Boltzmann models, play important roles in computational studies of biomolecules. A vital step in almost all implicit solvent models is to determine the solvent-solute interface, and the solvent…

Biological Physics · Physics 2021-05-20 Haixin Wei , Zekai Zhao , Ray Luo

We propose a numerical method for solving block-structured mesh partitioning problems based on the variational level-set method of (Zhao et al., J Comput Phys 127, 1996) which has been widely used in many partitioning problems such as image…

Computational Physics · Physics 2018-01-12 Shucheng Pan , Xiangyu Hu , Nikolaus. A. Adams

A robust numerical methodology to predict equilibrium interfaces over arbitrary solid surfaces is developed. The kernel of the proposed method is the distance regularized level set equations (DRLSE) with techniques to incorporate the…

Computational Physics · Physics 2019-12-24 Karim Alamé , Sreevatsa Anantharamu , Krishnan Mahesh

Bi-level optimization model is able to capture a wide range of complex learning tasks with practical interest. Due to the witnessed efficiency in solving bi-level programs, gradient-based methods have gained popularity in the machine…

Optimization and Control · Mathematics 2021-06-16 Risheng Liu , Xuan Liu , Xiaoming Yuan , Shangzhi Zeng , Jin Zhang

Energy-based latent variable models (EBLVMs) are more expressive than conventional energy-based models. However, its potential on visual tasks are limited by its training process based on maximum likelihood estimate that requires sampling…

Computer Vision and Pattern Recognition · Computer Science 2022-03-29 Ge Kan , Jinhu Lü , Tian Wang , Baochang Zhang , Aichun Zhu , Lei Huang , Guodong Guo , Hichem Snoussi

We investigate the level set method (LSM) in a specific quantum context; namely the dipole transition moment for a system with a nontrivial Morse potential. We draw equal moment sets in the two-dimensional space of two important parameters…

Quantum Physics · Physics 2007-05-23 Fariel Shafee

Interactive segmentation aims to precisely isolate target objects using sparse user guidance. However, traditional methods often suffer from heavy interaction burdens and parameter sensitivity, while deep learning approaches struggle with…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Jiachen Song , Dazhi Zhang , Fanghui Song , Zhichang Guo , Shengzhu Shi

A novel finite element framework is proposed for the numerical simulation of two phase flows with surface tension. The Level-Set (LS) method with piece-wise quadratic (P2) interpolation for the liquid-gas interface is used in order to reach…

Computational Engineering, Finance, and Science · Computer Science 2020-10-27 Modesar Shakoor , Chung Hae Park
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