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Photoacoustic fluctuation imaging, which exploits randomness in photoacoustic generation, provides enhanced images in terms of resolution and visibility, as compared to conventional photoacoustic images. While a few experimental…

Optics · Physics 2020-11-19 Sergey Vilov , Guillaume Godefroy , Bastien Arnal , Emmanuel Bossy

In deep tissue photoacoustic imaging the spatial resolution is inherently limited by the acoustic wavelength. We present an approach for surpassing the acoustic diffraction limit by exploiting temporal fluctuations in the sample absorption…

Optics · Physics 2017-05-31 Thomas Chaigne , Bastien Arnal , Sergey Vilov , Emmanuel Bossy , Ori Katz

In deep tissue photoacoustic imaging the spatial resolution is inherently limited by the acoustic wavelength. Recently, it was demonstrated that it is possible to surpass the acoustic diffraction limit by analyzing fluctuations in a set of…

In high-frequency photoacoustic imaging with uniform illumination, homogeneous photo-absorbing structures may be invisible because of their large size or limited-view issues. Here we show that, by exploiting dynamic speckle illumination, it…

Optics · Physics 2013-12-03 Jérôme Gateau , Thomas Chaigne , Ori Katz , Sylvain Gigan , Emmanuel Bossy

Ultrasound contrast imaging is a specialized imaging technique that applies microbubble contrast agents to traditional medical sonography, providing real-time visualization of blood flow and vessels. Gas-filled microbubbles are injected…

Analysis of PDEs · Mathematics 2024-12-17 Vanja Nikolić , Teresa Rauscher

Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore…

Optics · Physics 2026-01-06 David C. Garrett , Lihong V. Wang

Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that…

Medical Physics · Physics 2022-11-23 Prashant Pandey

Acoustic microstreaming has several industrial, therapeutic, and biomedical applications - Acoustic cleaning, micromixing, microfluid transport, hemolysis, sonoporation. The acoustic microstreaming due to the oscillation of ultrasound…

Fluid Dynamics · Physics 2022-01-19 Nima Mobadersany

In deep tissue photoacoustic imaging, the spatial resolution is inherently limited by acoustic diffraction. Moreover, as the ultrasound attenuation increases with frequency, resolution is often traded-off for penetration depth. Here we…

We analyze mathematically the acoustic imaging modality using bubbles as contrast agents. These bubbles are modeled by mass densities and bulk moduli enjoying contrasting scales. These contrasting scales allow them to resonate at certain…

Analysis of PDEs · Mathematics 2020-04-17 Alexander Dabrowski , Ahcene Ghandriche , Mourad Sini

Although the photoacoustic effect is most commonly generated by pulsed or amplitude modulated continuous optical sources, it is possible to generate acoustic waves by moving a constant amplitude, continuous light beam. If the light beam…

Applied Physics · Physics 2024-05-22 Xingchi Yan , Siyuan Song , Gerald J. Diebold

Contrast microbubbles (contrast agents) were initially developed to increase the contrast of the image in ultrasound imaging. These microbubbles consist of a gas core encapsulated by a layer of protein or lipid to stabilize them against…

Medical Physics · Physics 2018-02-26 Nima Mobadersany , Kausik Sarkar

Photoacoustic imaging is the leading technique for deep tissue optical imaging, allowing single-shot imaging at depths. However, its resolution may be limited by acoustic aberrations, caused by natural unknown heterogeneities in the tissue…

Optics · Physics 2026-05-01 Yevgeny Slobodkin , Ori Katz

Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…

Medical Physics · Physics 2018-04-11 Oren Solomon , Ruud J. G. van Sloun , Hessel Wijkstra , Massimo Mischi , Yonina C. Eldar

We deal with the photoacoustic imaging modality using dielectric nanoparticles as contrast agents. Exciting the heterogeneous tissue, localized in a bounded domain $\Omega$, with an electromagnetic wave, at a given incident frequency,…

Analysis of PDEs · Mathematics 2020-03-09 Ahcene Ghandriche , Mourad Sini

Subharmonic response from contrast microbubbles as a function of ambient overpressure is numerically investigated for subharmonic aided noninvasive estimation of local organ level blood pressure. Three different interfacial rheological…

Medical Physics · Physics 2015-07-20 Nima Mobadersany , Amit Katiyar , Kausik Sarkar

In recent years, photoacoustics has attracted intensive research for both anatomical and functional biomedical imaging. However, the physical interaction between photoacoustic generated endogenous waves and an exogenous ultrasound wave is a…

Optics · Physics 2016-01-22 Fei Gao , Xiaohua Feng , Yuanjin Zheng , Claus-Dieter Ohl

Photoacoustic imaging is a new non-destructive medical imaging technology based on photoacoustic effect. It can reflect the difference of light absorption energy by detecting photoacoustic signal. At present, the analysis methods of…

Optics · Physics 2021-02-03 Xianlin Song , Jianshuang Wei , Qi Jiang , Lingfang Song

Focused ultrasound stimulated microbubbles have been shown to be capable of inducing blood flow shutdown and necrosis in a range of tissue types in an approach termed antivascular ultrasound or mechanical ablation. In oncology, this…

Medical Physics · Physics 2022-10-17 Xiaoxiao Zhao , Carly Pellow , David E. Goertz

Recently we demonstrated an integrated photoacoustic (PA) and ultrasound (PAUS) system using a kHz-rate wavelength-tunable laser and a swept-beam delivery approach. It irradiates a medium using a narrow laser beam sweeping at high…

Signal Processing · Electrical Eng. & Systems 2020-01-28 MinWoo Kim , Geng-Shi Jeng , Matthew O'Donnell , Ivan Pelivanov
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