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Communication of signals among nodes in a complex network poses fundamental problems of efficiency and cost. Routing of messages along shortest paths requires global information about the topology, while spreading by diffusion, which…

Neurons and Cognition · Quantitative Biology 2019-06-19 Andrea Avena-Koenigsberger , Xiaoran Yan , Artemy Kolchinsky , Martijn van den Heuvel , Patric Hagmann , Olaf Sporns

Signal transduction within biological cells is governed by networks of interacting proteins. Communication between these proteins is mediated by signaling molecules which bind to receptors and induce stochastic transitions between different…

Molecular Networks · Quantitative Biology 2017-04-05 Gonzalo Hernandez-Hernandez , Jesse Myers , Enric Alvarez-Lacalle , Yohannes Shiferaw

Complex systems are characterized by multiple spatial and temporal scales. A natural framework to capture their multiscale nature is that of multilayer networks, where different layers represent distinct physical processes that often…

Statistical Mechanics · Physics 2024-04-29 Giorgio Nicoletti , Daniel Maria Busiello

Many real-world systems can be modeled as networks of interacting oscillatory units. Collective dynamics that are of functional relevance for the oscillator network, such as switching between metastable states, arise through the interplay…

Dynamical Systems · Mathematics 2019-08-05 Christian Bick

The brain works as a dynamic system to process information. Various challenges remain in understanding the connection between information and dynamics attributes in the brain. The present research pursues exploring how the characteristics…

Neurons and Cognition · Quantitative Biology 2022-07-14 Yang Tian , Guoqi Li , Pei Sun

Neural-network models of high-level brain functions such as memory recall and reasoning often rely on the presence of stochasticity. The majority of these models assumes that each neuron in the functional network is equipped with its own…

Neurons and Cognition · Quantitative Biology 2022-05-17 Jakob Jordan , Mihai A. Petrovici , Oliver Breitwieser , Johannes Schemmel , Karlheinz Meier , Markus Diesmann , Tom Tetzlaff

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

Suprathreshold stochastic resonance (SSR) is a form of noise enhanced signal transmission that occurs in a parallel array of independently noisy identical threshold nonlinearities, including model neurons. Unlike most forms of stochastic…

Statistical Mechanics · Physics 2007-07-02 Mark D. McDonnell , Nigel G. Stocks , Derek Abbott

First return maps of interspike intervals for biological neurons that generate repetitive bursts of impulses can display stereotyped structures (neuronal signatures). Such structures have been linked to the possibility of multicoding and…

Neurons and Cognition · Quantitative Biology 2015-06-22 Bóris Marin , Reynaldo Daniel Pinto , Robert C Elson , Eduardo Colli

Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings…

Neurons and Cognition · Quantitative Biology 2011-11-09 Kristina Lisa Klinkner , Cosma Rohilla Shalizi , Marcelo F. Camperi

We find that sensory noise delivered together with a weak periodic signal not only enhances nonlinear response of neuronal networks, but also improves the synchronization of the response to the signal. We reveal this phenomenon in neuronal…

Neurons and Cognition · Quantitative Biology 2015-08-25 M. A. Lopes , K. -E. Lee , A. V. Goltsev , J. F. F. Mendes

The ability of nonlinear dynamical systems to process incoming information is a key problem of many fundamental and applied sciences. Information processing by computation with attractors (steady states, limit cycles and strange attractors)…

Chaotic Dynamics · Physics 2015-06-26 Valentin S. Afraimovich , Mikhail I. Rabinovich , Pablo Varona

The interplay between nonlinear dynamic systems and noise has proved to be of great relevance in several application areas. In this presentation, we focus on the areas of information transmission and storage. We review some recent results…

Other Condensed Matter · Physics 2017-11-22 P. I. Fierens , G. A. Patterson , A. A. García , D. F. Grosz

We used various analytical and numerical techniques to elucidate signal propagation in a small enzymatic cascade which is subjected to external and internal noise. The nonlinear character of catalytic reactions, which underlie protein…

Molecular Networks · Quantitative Biology 2009-11-13 Yueheng Lan , Garegin A. Papoian

Heteroclinic structures organize global features of dynamical systems. We analyze whether heteroclinic structures can arise in network dynamics with higher-order interactions which describe the nonlinear interactions between three or more…

Dynamical Systems · Mathematics 2024-02-27 Christian Bick , Sören von der Gracht

In deep learning, neural networks serve as noisy channels between input data and its representation. This perspective naturally relates deep learning with the pursuit of constructing channels with optimal performance in information…

Machine Learning · Computer Science 2022-12-06 Kangyu Weng , Aohua Cheng , Ziyang Zhang , Pei Sun , Yang Tian

Brains learn to represent information from a large set of stimuli, typically by weak supervision. Unsupervised learning is therefore a natural approach for exploring the design of biological neural networks and their computations.…

Neurons and Cognition · Quantitative Biology 2025-10-17 Roy Urbach , Elad Schneidman

We develop numerical and analytical approaches to calculate mutual information between complete paths of two molecular components embedded into a larger reaction network. In particular, we focus on a continuous-time Markov chain formalism,…

Molecular Networks · Quantitative Biology 2022-08-09 Anne-Lena Moor , Christoph Zechner

Neural circuits exhibit remarkable computational flexibility, enabling adaptive responses to noisy and ever-changing environmental cues. A fundamental question in neuroscience concerns how a wide range of behaviors can emerge from a…

Statistical Mechanics · Physics 2025-09-18 Giacomo Barzon , Daniel M. Busiello , Giorgio Nicoletti

We theoretically describe how weak signals may be efficiently transmitted throughout more than one frequency range in noisy excitable media by kind of stochastic multiresonance. This serves us here to reinterpret recent experiments in…

Data Analysis, Statistics and Probability · Physics 2015-05-27 J. J. Torres , J. Marro , J. F. Mejias