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Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the…

Soft Condensed Matter · Physics 2009-11-10 Cornelis Storm , Jennifer J. Pastore , Fred C. MacKintosh , Tom C. Lubensky , Paul A. Janmey

Twisted assemblies of filaments in ropes, cables and bundles are essential structural elements in wide use in macroscopic materials as well as within the cells and tissues of living organisms. We develop the unique, non-linear elastic…

Soft Condensed Matter · Physics 2015-05-18 Gregory M. Grason

The elastic response is studied of a single flexible chain grafted on a rigid plane and an ensemble of non-interacting tethered chains. It is demonstrated that the entropic theory of rubber elasticity leads to conclusions that disagree with…

Statistical Mechanics · Physics 2007-05-23 A. D. Drozdov

Geometric and structural constraints greatly restrict the selection of folds adapted by protein backbones, and yet, folded proteins show an astounding diversity in functionality. For structure to have any bearing on function, it is thus…

Biological Physics · Physics 2010-04-20 Brinda K. V. , Saraswathi Vishveshwara , Smitha Vishveshwara

Networks effectively capture interactions among components of complex systems, and have thus become a mainstay in many scientific disciplines. Growing evidence, especially from biology, suggest that networks undergo changes over time, and…

Methodology · Statistics 2020-03-10 Ali Shojaie

This paper is motivated by the complex blister patterns sometimes seen in thin elastic films on thick, compliant substrates. These patterns are often induced by an elastic misfit which compresses the film. Blistering permits the film to…

Analysis of PDEs · Mathematics 2013-04-02 Jacob Bedrossian , Robert V. Kohn

The mechanical properties of biological materials are spatially heterogeneous. Typical tissues are made up of a spanning fibrous extracellular matrix in which various inclusions, such as living cells, are embedded. While the influence of…

Soft Condensed Matter · Physics 2025-09-04 Jordan L. Shivers , Jingchen Feng , Fred C. MacKintosh

A theoretical analysis of the effect of force and torque on spontaneously twisted, fluctuating elastic ribbons is presented. We find that when a filament with a straight center line and a spontaneously twisted noncircular cross section is…

Soft Condensed Matter · Physics 2007-05-23 S. Panyukov , Y. Rabin

The rigidity of elastic networks depends sensitively on their internal connectivity and the nature of the interactions between constituents. Particles interacting via central forces undergo a zero-temperature rigidity-percolation transition…

Soft Condensed Matter · Physics 2011-12-08 Chase P. Broedersz , Xiaoming Mao , T. C. Lubensky , F. C. MacKintosh

The macroscopic response of short fiber reinforced composites is dependent on an extensive range of microstructural parameters. Thus, micromechanical modeling of these materials is challenging and in some cases, computationally expensive.…

Machine Learning · Computer Science 2022-10-04 J. Friemann , B. Dashtbozorg , M. Fagerström , S. M. Mirkhalaf

Recurrent neural networks (RNNs) trained on low-dimensional tasks have been widely used to model functional biological networks. However, the solutions found by learning and the effect of initial connectivity are not well understood. Here,…

Neurons and Cognition · Quantitative Biology 2021-05-17 Friedrich Schuessler , Francesca Mastrogiuseppe , Alexis Dubreuil , Srdjan Ostojic , Omri Barak

We introduce a mathematical model for the mechanical behaviour of the eukaryotic cell cytoskeleton. This discrete model involves a regular array of pre-stressed protein filaments that exhibit resistance to enthalpic stretching, joined at…

Quantitative Methods · Quantitative Biology 2023-09-06 J. Köry , N. A. Hill , X. Y. Luo , P. S. Stewart

We investigate the interplay between pre-stress and mechanical properties in random elastic networks. To do this in a controlled fashion, we introduce an algorithm for creating random freestanding frames that support exactly one state of…

Disordered Systems and Neural Networks · Physics 2019-02-20 Anwesha Bose , Mathijs F. J. Vermeulen , Cornelis Storm , Wouter G. Ellenbroek

We develop two generalizations of contraction theory, namely, semi-contraction and weak-contraction theory. First, using the notion of semi-norm, we propose a geometric framework for semi-contraction theory. We introduce matrix…

Systems and Control · Electrical Eng. & Systems 2020-10-06 Saber Jafarpour , Pedro Cisneros-Velarde , Francesco Bullo

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

Neurons and Cognition · Quantitative Biology 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha

The characterization of the "most connected" nodes in static or slowly evolving complex networks has helped in understanding and predicting the behavior of social, biological, and technological networked systems, including their robustness…

Physics and Society · Physics 2010-10-21 Scott A. Hill , Dan Braha

Strain energy density is calculated for a network of flexible chains with weak excluded-volume interactions (whose energy is small compared with thermal energy). Constitutive equations are developed for an incompressible network of chains…

Statistical Mechanics · Physics 2007-05-23 A. D. Drozdov

The non-linear stress-strain relation for crosslinked polymer networks is studied using molecular dynamics simulations. Previously we demonstrated the importance of trapped entanglements in determining the elastic and relaxational…

Soft Condensed Matter · Physics 2009-10-31 Gary S. Grest , Mathias Puetz , Kurt Kremer , Ralf Everaers

Random networks are a powerful tool in the analytical modeling of complex networks as they allow us to write approximate mathematical models for diverse properties and behaviors of networks. One notable shortcoming of these models is that…

Physics and Society · Physics 2023-07-10 Laurent Hébert-Dufresne , Márton Pósfai , Antoine Allard

We study the elasto-plastic behaviour of materials made of individual (discrete) objects, such as a liquid foam made of bubbles. The evolution of positions and mutual arrangements of individual objects is taken into account through…

Soft Condensed Matter · Physics 2015-05-18 Christophe Raufaste , Simon Cox , Philippe Marmottant , François Graner