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Molecular property optimization (MPO) problems are inherently challenging since they are formulated over discrete, unstructured spaces and the labeling process involves expensive simulations or experiments, which fundamentally limits the…

Biomolecules · Quantitative Biology 2024-01-04 Farshud Sorourifar , Thomas Banker , Joel A. Paulson

Model reduction, which aims to learn a simpler model of the original mixed integer linear programming (MILP), can solve large-scale MILP problems much faster. Most existing model reduction methods are based on variable reduction, which…

Machine Learning · Computer Science 2026-02-04 Jiajun Li , Yixuan Li , Ran Hou , Yu Ding , Shisi Guan , Jiahui Duan , Xiongwei Han , Tao Zhong , Vincent Chau , Weiwei Wu , Wanyuan Wang

Embedding deep neural networks (NNs) into mixed-integer programs (MIPs) is attractive for decision making with learned constraints, yet state-of-the-art monolithic linearisations blow up in size and quickly become intractable. In this…

Optimization and Control · Mathematics 2025-11-13 Shuli Zeng , Sijia Zhang , Feng Wu , Shaojie Tang , Xiang-Yang Li

This paper introduces $\Delta$-MILP, a powerful variant of the mixed-integer linear programming (MILP) optimization framework to solve NASA's Deep Space Network (DSN) scheduling problem. This work is an extension of our original MILP…

Optimization and Control · Mathematics 2022-04-27 Thomas Claudet , Ryan Alimo , Edwin Goh , Mark Johnston , Ramtin Madani , Brian Wilson

Planning in hybrid systems with both discrete and continuous control variables is important for dealing with real-world applications such as extra-planetary exploration and multi-vehicle transportation systems. Meanwhile, generating…

Robotics · Computer Science 2021-02-23 Jingkai Chen , Brian Williams , Chuchu Fan

We propose a supervised learning framework for computing solutions of multi-parametric Mixed Integer Linear Programs (MILPs) that arise in Model Predictive Control. Our approach also quantifies sub-optimality for the computed solutions.…

Systems and Control · Electrical Eng. & Systems 2023-03-24 Luigi Russo , Siddharth H. Nair , Luigi Glielmo , Francesco Borrelli

In this paper, we consider mixed-integer nonsmooth constrained optimization problems whose objective/constraint functions are available only as the output of a black-box zeroth-order oracle (i.e., an oracle that does not provide derivative…

Optimization and Control · Mathematics 2021-07-02 Tommaso Giovannelli , Giampaolo Liuzzi , Stefano Lucidi , Francesco Rinaldi

Mixed-integer linear programming (MILP) stands as a notable NP-hard problem pivotal to numerous crucial industrial applications. The development of effective algorithms, the tuning of solvers, and the training of machine learning models for…

Machine Learning · Computer Science 2023-10-23 Haoyu Wang , Jialin Liu , Xiaohan Chen , Xinshang Wang , Pan Li , Wotao Yin

By exploiting the correlation between the structure and the solution of Mixed-Integer Linear Programming (MILP), Machine Learning (ML) has become a promising method for solving large-scale MILP problems. Existing ML-based MILP solvers…

Machine Learning · Computer Science 2025-01-03 Yixuan Li , Can Chen , Jiajun Li , Jiahui Duan , Xiongwei Han , Tao Zhong , Vincent Chau , Weiwei Wu , Wanyuan Wang

Mixed Integer Linear Programming (MILP) can be considered the backbone of the modern power system optimization process, with a large application spectrum, from Unit Commitment and Optimal Transmission Switching to verifying Neural Networks…

Quantum Physics · Physics 2024-04-17 Petros Ellinas , Samuel Chevalier , Spyros Chatzivasileiadis

In this letter, we consider the Multi-Robot Efficient Search Path Planning (MESPP) problem, where a team of robots is deployed in a graph-represented environment to capture a moving target within a given deadline. We prove this problem to…

Robotics · Computer Science 2021-01-14 Beatriz A. Asfora , Jacopo Banfi , Mark Campbell

Mixed Integer Linear Programming (MILP) is a well-known approach for the cryptanalysis of a symmetric cipher. A number of MILP-based security analyses have been reported for non-linear (SBoxes) and linear layers. Researchers proposed word-…

Cryptography and Security · Computer Science 2023-06-06 Debranjan Pal , Vishal Pankaj Chandratreya , Dipanwita Roy Chowdhury

Mixed Integer Linear Programming (MILP) is a pillar of mathematical optimization that offers a powerful modeling language for a wide range of applications. During the past decades, enormous algorithmic progress has been made in solving…

Optimization and Control · Mathematics 2024-02-09 Lara Scavuzzo , Karen Aardal , Andrea Lodi , Neil Yorke-Smith

Mixed-Integer Programming (MIP), particularly Mixed-Integer Linear Programming (MILP) and Mixed-Integer Quadratic Programming (MIQP), has found extensive applications in domains such as portfolio optimization and network flow control, which…

Optimization and Control · Mathematics 2026-02-03 Zayn Wang

We propose a novel high-dimensional linear regression estimator: the Discrete Dantzig Selector, which minimizes the number of nonzero regression coefficients subject to a budget on the maximal absolute correlation between the features and…

Methodology · Statistics 2017-01-20 Rahul Mazumder , Peter Radchenko

We propose a unified framework to address a family of classical mixed-integer optimization problems with logically constrained decision variables, including network design, facility location, unit commitment, sparse portfolio selection,…

Optimization and Control · Mathematics 2021-10-19 Dimitris Bertsimas , Ryan Cory-Wright , Jean Pauphilet

We present an integrated prediction-optimization (PredOpt) framework to efficiently solve sequential decision-making problems by predicting the values of binary decision variables in an optimal solution. We address the key issues of…

Machine Learning · Computer Science 2023-11-14 Dogacan Yilmaz , İ. Esra Büyüktahtakın

The goal of survey design is often to minimize the errors associated with inference: the total of bias and variance. Random surveys are common because they allow the use of theoretically unbiased estimators. In practice however, such…

Methodology · Statistics 2023-02-14 Connie Okasaki , Sándor F. Tóth , Andrew M. Berdahl

This paper introduces a novel algorithm for Mixed-Integer Nonlinear Programming (MINLP) problems with multilinear interpolations of look-up tables. These problems arise when objective or constraints contain black-box functions only known at…

In model predictive control (MPC) for hybrid systems, solving optimization problems efficiently and with guarantees on worst-case computational complexity is critical to satisfy the real-time constraints in these applications. These…

Systems and Control · Electrical Eng. & Systems 2025-04-11 Shamisa Shoja , Daniel Arnström , Daniel Axehill