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I describe a framework for adaptive scientific exploration based on iterating an Observation--Inference--Design cycle that allows adjustment of hypotheses and observing protocols in response to the results of observation on-the-fly, as data…

Astrophysics · Physics 2009-11-10 Thomas J. Loredo

Optimal control of complex environments with robotic systems faces two complementary and intertwined challenges: efficient organization of sensory state information and far-sighted action planning. Because the reinforcement learning…

Machine Learning · Computer Science 2026-01-30 Abdullah Akgül , Gulcin Baykal , Manuel Haußmann , Mustafa Mert Çelikok , Melih Kandemir

Neural responses in the cortex change over time both systematically, due to ongoing plasticity and learning, and seemingly randomly, due to various sources of noise and variability. Most previous work considered each of these processes,…

Neurons and Cognition · Quantitative Biology 2018-07-25 Laurence Aitchison , Guillaume Hennequin , Mate Lengyel

Understanding brain function, constructing computational models and engineering neural prosthetics require assessing two problems, namely encoding and decoding, but their relation remains controversial. For decades, the encoding problem has…

Neurons and Cognition · Quantitative Biology 2017-01-16 Hugo Gabriel Eyherabide

Dual-process theories play a central role in both psychology and neuroscience, figuring prominently in fields ranging from executive control to reward-based learning to judgment and decision making. In each of these domains, two mechanisms…

Neurons and Cognition · Quantitative Biology 2023-10-11 Ted Moskovitz , Kevin Miller , Maneesh Sahani , Matthew M. Botvinick

A neuron transforms its input into output spikes, and this transformation is the basic unit of computation in the nervous system. The spiking response of the neuron to a complex, time-varying input can be predicted from the detailed…

Neurons and Cognition · Quantitative Biology 2011-12-19 Michael Famulare , Adrienne Fairhall

Data is scaling exponentially in fields ranging from genomics to neuroscience to economics. A central question is: can modern machine learning methods be applied to construct predictive models of natural systems like cells and brains based…

Statistical Mechanics · Physics 2018-08-17 Audrey Huang , Benjamin Sheldan , David A. Sivak , Matt Thomson

Bayesian inversion is central to the quantification of uncertainty within problems arising from numerous applications in science and engineering. To formulate the approach, four ingredients are required: a forward model mapping the unknown…

Machine Learning · Statistics 2025-05-15 O. Deniz Akyildiz , Mark Girolami , Andrew M. Stuart , Arnaud Vadeboncoeur

Dynamics play a critical role in computation. The principled evolution of states over time enables both biological and artificial networks to represent and integrate information to make decisions. In the past few decades, significant…

Neurons and Cognition · Quantitative Biology 2023-11-28 Jason Z. Kim , Bart Larsen , Linden Parkes

A steadily increasing body of evidence suggests that the brain performs probabilistic inference to interpret and respond to sensory input and that trial-to-trial variability in neural activity plays an important role. The neural sampling…

Neurons and Cognition · Quantitative Biology 2017-07-07 Ilja Bytschok , Dominik Dold , Johannes Schemmel , Karlheinz Meier , Mihai A. Petrovici

The goal of this paper is to solve a class of stochastic optimal control problems numerically, in which the state process is governed by an It\^o type stochastic differential equation with control process entering both in the drift and the…

Optimization and Control · Mathematics 2020-06-05 Richard Archibald , Feng Bao , Jiongmin Yong , Tao Zhou

We consider a group synchronization problem with multiple frequencies which involves observing pairwise relative measurements of group elements on multiple frequency channels, corrupted by Gaussian noise. We study the computational phase…

Statistics Theory · Mathematics 2024-06-06 Anastasia Kireeva , Afonso S. Bandeira , Dmitriy Kunisky

This paper deals with differentiable dynamical models congruent with neural process theories that cast brain function as the hierarchical refinement of an internal generative model explaining observations. Our work extends existing…

Machine Learning · Computer Science 2021-12-10 André Ofner , Sebastian Stober

Estimation of parameters in differential equation models can be achieved by applying learning algorithms to quantitative time-series data. However, sometimes it is only possible to measure qualitative changes of a system in response to a…

Machine Learning · Computer Science 2021-10-28 Gregory Szep , Neil Dalchau , Attila Csikasz-Nagy

Diffusion models have shown unprecedented success in the task of text-to-image generation. While these models are capable of generating high-quality and realistic images, the complexity of sequential denoising has raised societal concerns…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Qinchan Li , Kenneth Chen , Changyue Su , Qi Sun

Quantum computing allows for the manipulation of highly correlated states whose properties quickly go beyond the capacity of any classical method to calculate. Thus one natural problem which could lend itself to quantum advantage is the…

Quantum Physics · Physics 2024-12-19 Kevin Lively , Tim Bode , Jochen Szangolies , Jian-Xin Zhu , Benedikt Fauseweh

Feedback optimization has emerged as a promising approach for regulating dynamical systems to optimal steady states that are implicitly defined by underlying optimization problems. Despite their effectiveness, existing methods face two key…

Optimization and Control · Mathematics 2025-09-18 Gianluca Bianchin , Bryan Van Scoy

Quantum optimal control plays a vital role in many quantum technologies, including quantum computation. One of the most important control parameters to optimise for is the evolution time (pulse duration). However, most existing works focus…

Quantum Physics · Physics 2025-04-02 Minjun Jeon , Zhenyu Cai

Information theory is a practical and theoretical framework developed for the study of communication over noisy channels. Its probabilistic basis and capacity to relate statistical structure to function make it ideally suited for studying…

Neurons and Cognition · Quantitative Biology 2015-01-09 Simon R. Schultz , Robin A. A. Ince , Stefano Panzeri

Perturbation theory is an important technique for reducing computational cost and providing physical insights in simulating quantum systems with classical computers. Here, we provide a quantum algorithm to obtain perturbative energies on…

Quantum Physics · Physics 2023-05-17 Kosuke Mitarai , Kiichiro Toyoizumi , Wataru Mizukami