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A central challenge for intelligent agents in an uncertain world is striking the right balance between utility maximization and resource use, not only for external movement but also for internal computation. Existing theories of control…

Artificial Intelligence · Computer Science 2026-05-19 Itzel Olivos-Castillo , Paul Schrater , Xaq Pitkow

Patterns of microcircuitry suggest that the brain has an array of repeated canonical computational units. Yet neural representations are distributed, so the relevant computations may only be related indirectly to single-neuron…

Neurons and Cognition · Quantitative Biology 2023-10-17 Rajkumar Vasudeva Raju , Zhe Li , Scott Linderman , Xaq Pitkow

Inference is a versatile tool that underlies scientific discovery, machine learning, and everyday decision-making: it describes how an agent updates a probability distribution as partial information is acquired from multiple measurements,…

Statistical Mechanics · Physics 2026-01-27 Nathan Shettell , Alexia Auffèves

Does the brain construct an efficient representation of the sensory world? We review progress on this question, focusing on a series of experiments in the last decade which use fly vision as a model system in which theory and experiment can…

Neurons and Cognition · Quantitative Biology 2007-12-31 William Bialek , Rob R. de Ruyter van Steveninck , Naftali Tishby

Computational level explanations based on optimal feedback control with signal-dependent noise have been able to account for a vast array of phenomena in human sensorimotor behavior. However, commonly a cost function needs to be assumed for…

Machine Learning · Computer Science 2021-10-22 Matthias Schultheis , Dominik Straub , Constantin A. Rothkopf

The performance, reliability, cost, size and energy usage of computing systems can be improved by one or more orders of magnitude by the systematic use of modern control and optimization methods. Computing systems rely on the use of…

Systems and Control · Computer Science 2017-10-13 Eric C. Kerrigan

Predictive coding is an influential model of cortical neural activity. It proposes that perceptual beliefs are furnished by sequentially minimising "prediction errors" - the differences between predicted and observed data. Implicit in this…

Neurons and Cognition · Quantitative Biology 2022-04-07 Alexander Tschantz , Beren Millidge , Anil K Seth , Christopher L Buckley

The mammalian brain is a metabolically expensive device, and evolutionary pressures have presumably driven it to make productive use of its resources. For sensory areas, this concept has been expressed more formally as an optimality…

Neurons and Cognition · Quantitative Biology 2016-03-02 Deep Ganguli , Eero P. Simoncelli

The network inference problem arises in biological research when one needs to quantitatively choose the best protein-interaction model for explaining a phenotype. The diverse nature of the data and nonlinear dynamics pose significant…

Molecular Networks · Quantitative Biology 2025-12-22 Guy Karlebach

Brain-inspired machine learning is gaining increasing consideration, particularly in computer vision. Several studies investigated the inclusion of top-down feedback connections in convolutional networks; however, it remains unclear how and…

Computer Vision and Pattern Recognition · Computer Science 2021-06-09 Andrea Alamia , Milad Mozafari , Bhavin Choksi , Rufin VanRullen

Almost all neural computations involve making predictions. Whether an organism is trying to catch prey, avoid predators, or simply move through a complex environment, the data it collects through its senses can guide its actions only to the…

Neurons and Cognition · Quantitative Biology 2015-07-02 Jared Salisbury , Stephanie E. Palmer

Efficient coding theory posits that sensory circuits transform natural signals into neural representations that maximize information transmission subject to resource constraints. Local interneurons are thought to play an important role in…

Neurons and Cognition · Quantitative Biology 2025-01-22 David Lipshutz , Eero P. Simoncelli

Reasoning models improve their problem-solving ability through inference-time scaling, allocating more compute via longer token budgets. Identifying which reasoning traces are likely to succeed remains a key opportunity: reliably predicting…

Artificial Intelligence · Computer Science 2025-10-14 Martina G. Vilas , Safoora Yousefi , Besmira Nushi , Eric Horvitz , Vidhisha Balachandran

Efficient signal representation is essential for the functioning of living and artificial systems operating under resource constraints. A widely recognized framework for deriving such representations is the information bottleneck method,…

Molecular Networks · Quantitative Biology 2025-07-08 Vahe Galstyan , Age Tjalma , Pieter Rein ten Wolde

Active inference is a normative framework for explaining behaviour under the free energy principle -- a theory of self-organisation originating in neuroscience. It specifies neuronal dynamics for state-estimation in terms of a descent on…

Neurons and Cognition · Quantitative Biology 2021-10-26 Lancelot Da Costa , Thomas Parr , Biswa Sengupta , Karl Friston

Darwinian evolution tends to produce energy-efficient outcomes. On the other hand, energy limits computation, be it neural and probabilistic or digital and logical. Taking a particular energy-efficient viewpoint, we define neural…

Neurons and Cognition · Quantitative Biology 2021-04-05 William B Levy , Victoria G. Calvert

The response time of physical computational elements is finite, and neurons are no exception. In hierarchical models of cortical networks each layer thus introduces a response lag. This inherent property of physical dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-10-28 Paul Haider , Benjamin Ellenberger , Laura Kriener , Jakob Jordan , Walter Senn , Mihai A. Petrovici

We investigate the performance of sparsely-connected networks of integrate-and-fire neurons for ultra-short term information processing. We exploit the fact that the population activity of networks with balanced excitation and inhibition…

Neurons and Cognition · Quantitative Biology 2007-05-23 Julien Mayor , Wulfram Gerstner

Biological neural networks face a formidable task: performing reliable computations in the face of intrinsic stochasticity in individual neurons, imprecisely specified synaptic connectivity, and nonnegligible delays in synaptic…

Neurons and Cognition · Quantitative Biology 2020-06-26 Jonathan Kadmon , Jonathan Timcheck , Surya Ganguli

Optimization results are one method for understanding neural computation from Nature's perspective and for defining the physical limits on neuron-like engineering. Earlier work looks at individual properties or performance criteria and…

Neurons and Cognition · Quantitative Biology 2017-12-21 William B Levy , Toby Berger , Mustafa Sungkar
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