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This paper describes the algorithm and examines the performance of an IMRT beam-angle optimization (BAO) system. In this algorithm successive sets of beam angles are selected from a set of predefined directions using a fast simulated…

Medical Physics · Physics 2009-11-10 David Djajaputra , Qiuwen Wu , Yan Wu , Radhe Mohan

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, especially for pencil beam scanning proton therapy (PBSPT). Our…

Group Relative Policy Optimization (GRPO) has shown promise in aligning image and video generative models with human preferences. However, applying it to modern flow matching models is challenging because of its deterministic sampling…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Dailan He , Guanlin Feng , Xingtong Ge , Yazhe Niu , Yi Zhang , Bingqi Ma , Guanglu Song , Yu Liu , Hongsheng Li

Recent works in automated radiotherapy treatment planning have used machine learning based on historical treatment plans to infer the spatial dose distribution for a novel patient directly from the planning image. We present an atlas-based…

Medical Physics · Physics 2017-08-02 Chris McIntosh , Mattea Welch , Andrea McNiven , David A. Jaffray , Thomas G. Purdie

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Mandible Osteoradionecrosis (ORN) is one of the most severe adverse events (AEs) for head and neck (H&N) cancer radiotherapy. Previous retrospective investigations on real-world data relied on conventional statistical models that primarily…

Direct Preference Optimization (DPO) has been successfully used to align large language models (LLMs) according to human preferences, and more recently it has also been applied to improving the quality of text-to-image diffusion models.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Shivanshu Shekhar , Shreyas Singh , Tong Zhang

In medicine, needles are frequently used to deliver treatments to subsurface targets or to take tissue samples from the inside of an organ. Current clinical practice is to insert needles under image guidance or haptic feedback, although…

Systems and Control · Electrical Eng. & Systems 2020-04-29 Antje Rogalla , Sascha Lehmann , Maximilian Neidhardt , Johanna Sprenger , Marcel Bengs , Alexander Schlaefer , Sibylle Schupp

The steep dose gradients obtained with pencil beam scanning allow for precise tumor targeting at the cost of high sensitivity to uncertainties. Robust optimization is commonly applied to mitigate uncertainties in density and patient setup,…

Medical Physics · Physics 2024-11-26 Ivar Bengtsson , Anders Forsgren , Albin Fredriksson , Ye Zhang

In this work, we propose a Machine Learning model that generates an adjustable 3D dose distribution for external beam radiation therapy for head-and-neck cancer treatments. In contrast to existing Machine Learning methods that provide a…

Neural Radiance Field (NeRF) based rendering has attracted growing attention thanks to its state-of-the-art (SOTA) rendering quality and wide applications in Augmented and Virtual Reality (AR/VR). However, immersive real-time (> 30 FPS)…

Hardware Architecture · Computer Science 2025-03-31 Chaojian Li , Sixu Li , Yang Zhao , Wenbo Zhu , Yingyan Celine Lin

Dynamic Sparse Training (DST) methods train neural networks by maintaining sparsity while dynamically adapting the network topology. Despite the promise of reduced computation, DST methods converge significantly slower than dense training,…

Machine Learning · Computer Science 2026-05-28 Mohammed Adnan , Rohan Jain , Tom Jacobs , Ekansh Sharma , Rahul G. Krishnan , Rebekka Burkholz , Yani Ioannou

This paper focuses on a research problem of robotic controlled laser orientation to minimize errant overcutting of healthy tissue during the course of pathological tissue resection. Laser scalpels have been widely used in surgery to remove…

Robotics · Computer Science 2022-01-06 Guangshen Ma , Weston Ross , Patrick J. Codd

Recently, Agentic Reinforcement Learning (Agentic RL) has made significant progress in incentivizing the multi-turn, long-horizon tool-use capabilities of web agents. While mainstream agentic RL algorithms autonomously explore…

Objective: We propose a semiautomatic pipeline for radiation therapy treatment planning, combining ideas from machine learning-automated planning and multicriteria optimization (MCO). Approach: Using knowledge extracted from historically…

Medical Physics · Physics 2022-02-16 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Tuning active prostheses for people with amputation is time-consuming and relies on metrics that may not fully reflect user needs. We introduce a human-in-the-loop optimization (HILO) approach that leverages direct user preferences to…

Low-dose computed tomography (LDCT) is critical for minimizing radiation exposure, but it often leads to increased noise and reduced image quality. Traditional denoising methods, such as iterative optimization or supervised learning, often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Debopom Sutradhar , Ripon Kumar Debnath , Mohaimenul Azam Khan Raiaan , Yan Zhang , Reem E. Mohamed , Sami Azam

Distributionally robust optimization (DRO) is a widely-used approach to learn models that are robust against distribution shift. Compared with the standard optimization setting, the objective function in DRO is more difficult to optimize,…

Machine Learning · Computer Science 2021-10-27 Jikai Jin , Bohang Zhang , Haiyang Wang , Liwei Wang

Purpose: This study quantifies the variation in dose-volume histogram (DVH) and normal tissue complication probability (NTCP) metrics for head-and-neck (HN) cancer patients when alternative organ-at-risk (OAR) delineations are used for…

Accurate multi-needle localization in intraoperative CT images is crucial for optimizing seed placement in pelvic seed implant brachytherapy. However, this task is challenging due to poor image contrast and needle adhesion. This paper…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Zhuo Xiao , Fugen Zhou , Jingjing Wang , Chongyu He , Bo Liu , Haitao Sun , Zhe Ji , Yuliang Jiang , Junjie Wang , Qiuwen Wu