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Hard X-ray tomography with Paganin's widespread single-distance phase retrieval filter improves contrast-to-noise ratio (CNR) while reducing spatial resolution (SR). We demonstrate that a Gaussian filter provided larger CNR at high SR with…

Medical Physics · Physics 2020-01-22 Griffin Rodgers , Georg Schulz , Hans Deyhle , Willy Kuo , Christoph Rau , Timm Weitkamp , Bert Müller

New statistical methods were employed to improve the ability to distinguish benign from malignant breast tissue ex vivo in a recent study. The ultimately aim was to improve the intraoperative assessment of positive tumour margins in…

Quantitative Methods · Quantitative Biology 2018-05-04 A Santaolalla , M Sheikh , M Van Hemelrijck , A Portieri , ACC Coolen

In this paper, we propose the SPR (sparse phase retrieval) method, which is a new phase retrieval method for coherent x-ray diffraction imaging (CXDI). Conventional phase retrieval methods effectively solve the problem for high…

Data Analysis, Statistics and Probability · Physics 2016-03-29 Shiro Ikeda , Hidetoshi Kono

We present an algorithm for coherent diffractive imaging with phaseless measurements. It treats the forward model as a combination of coherent and incoherent waves. The algorithm reconstructs absorption and phase contrast that quantifies…

Computational Physics · Physics 2022-08-25 Miguel Moscoso , Alexei Novikov , George Papanicolaou , Chrysoula Tsogka

In recent years, a novel x-ray imaging modality has emerged that reveals unresolved sample microstructure via a "dark-field image", which provides complementary information to conventional "bright-field" images, such as attenuation and…

With the development of terahertz time-domain spectroscopy, methods have been proposed to precisely estimate the thickness, refractive index, and attenuation coefficient of a sample. In this article, we propose a new method to compute these…

One of the most prominent challenges in the field of diffractive imaging is the phase retrieval (PR) problem: In order to reconstruct an object from its diffraction pattern, the inverse Fourier transform must be computed. This is only…

Image and Video Processing · Electrical Eng. & Systems 2022-05-06 Simon Welker , Tal Peer , Henry N. Chapman , Timo Gerkmann

In this paper, we develop a novel phase retrieval approach to reconstruct x-ray differential phase shift induced by an object. A primary advantage of our approach is a higher-order accuracy over that with the conventional linear…

Medical Physics · Physics 2010-03-18 Wenxiang Cong , Ge Wang

Ptychography has risen as a reference X-ray imaging technique: it achieves resolutions of one billionth of a meter, macroscopic field of view, or the capability to retrieve chemical or magnetic contrast, among other features. A…

Optimization and Control · Mathematics 2019-06-10 Huibin Chang , Pable Enfedaque , Stefano Marchesini

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object…

Medical Physics · Physics 2017-09-08 Joemini Poudel , Thomas P. Matthews , Lei Li , Mark A. Anastasio , Lihong V. Wang

Phase-retrieval from coded diffraction patterns (CDP) is important to X-ray crystallography, diffraction tomography and astronomical imaging, yet remains a hard, non-convex inverse problem. We show that CDP recovery can be reformulated…

X-ray micro tomography is a non-destructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology and medical research.…

Coherent wave-propagation in the near-field Fresnel-regime is the underlying contrast-mechanism to (propagation-based) X-ray phase contrast imaging (XPCI), an emerging lensless technique that enables 2D- and 3D-imaging of biological soft…

Numerical Analysis · Mathematics 2018-11-06 Simon Maretzke

Purpose: Grating-based imaging (GBI) and edge-illumination (EI) are two promising types of XPCI as the conventional x-ray sources can be directly utilized. For GBI and EI systems, the phase-stepping acquisition with multiple exposures at a…

Medical Physics · Physics 2022-01-19 Chengpeng Wu , Yuxiang Xing , Li Zhang , Zhiqiang Chen , Xiaohua Zhu , Xi Zhang , Hewei Gao

Quantitative phase imaging has become a topic of considerable interest in the microscopy community. We have recently described one such technique based on the use of a partitioned detection aperture, which can be operated in a single shot…

Optics · Physics 2015-10-20 Roman Barankov , Jean-Charles Baritaux , Jerome Mertz

Image restoration aims to recover high-quality images from degraded observations. When the degradation process is known, the recovery problem can be formulated as an inverse problem, and in a Bayesian context, the goal is to sample a clean…

Image and Video Processing · Electrical Eng. & Systems 2025-10-13 Darshan Thaker , Abhishek Goyal , René Vidal

Accurate computational ptychographic phase reconstructions are enabled by fast direct-electron cameras with high dynamic ranges used for four-dimensional scanning transmission electron microscopy (4D-STEM). The availability of open software…

Materials Science · Physics 2025-05-01 Toma Susi

We introduce a probabilistic approach to ptychographic reconstruction in computational imaging. Ptychography is an imaging method where the complex amplitude of an object is estimated from a sequence of diffraction measurements. We…

Applications · Statistics 2025-04-09 Hajime Ueda , Shun Katakami , Masato Okada

We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…

Instrumentation and Detectors · Physics 2023-12-21 Michela Esposito , Nicole Schieber , Alessandro Olivo , Yannick Schwab , Marco Endrizzi

Speckle-based phase-contrast X-ray imaging (SB-PCXI) can reconstruct high-resolution images of weakly-attenuating materials that would otherwise be indistinguishable in conventional attenuation-based imaging. The experimental setup of…

Medical Physics · Physics 2023-07-31 Samantha J. Alloo , Kaye S. Morgan , David M. Paganin , Konstantin M. Pavlov
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