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Motivation: The importance of clinical data in understanding the pathophysiology of complex disorders has prompted the launch of multiple initiatives designed to generate patient-level data from various modalities. While these studies can…

This work investigates the use of mixed-norm regularization for sensor selection in Event-Related Potential (ERP) based Brain-Computer Interfaces (BCI). The classification problem is cast as a discriminative optimization framework where…

Machine Learning · Computer Science 2014-03-17 Rémi Flamary , Nisrine Jrad , Ronald Phlypo , Marco Congedo , Alain Rakotomamonjy

Harmonization of T1-weighted MR images across different scanners is crucial for ensuring consistency in neuroimaging studies. This study introduces a novel approach to direct image harmonization, moving beyond feature standardization to…

Cognitive diagnosis models have been popularly used in fields such as education, psychology, and social sciences. While parametric likelihood estimation is a prevailing method for fitting cognitive diagnosis models, nonparametric…

Statistics Theory · Mathematics 2025-10-01 Chengyu Cui , Yanlong Liu , Gongjun Xu

Alzheimer's disease (AD) is the most common type of dementia accompanied with brain atrophy. Structural measurements of brain atrophy in specific brain structures such as hippocampus using magnetic resonance imaging (MRI) have been reported…

Medical Physics · Physics 2016-05-10 Kenya Murase , Naohiko Gondo , Tsutomu Soma

We investigate methods for parameter learning from incomplete data that is not missing at random. Likelihood-based methods then require the optimization of a profile likelihood that takes all possible missingness mechanisms into account.…

Methodology · Statistics 2012-07-02 Manfred Jaeger

Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine. However, these…

Mixed linear regression is a well-studied problem in parametric statistics and machine learning. Given a set of samples, tuples of covariates and labels, the task of mixed linear regression is to find a small list of linear relationships…

Machine Learning · Statistics 2024-06-04 Avishek Ghosh , Arya Mazumdar

Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream…

Machine Learning · Computer Science 2019-10-02 S. Soroush Haj Zargarbashi , Bagher Babaali

Gaussian mixture models (GMMs) are fundamental statistical tools for modeling heterogeneous data. Due to the nonconcavity of the likelihood function, the Expectation-Maximization (EM) algorithm is widely used for parameter estimation of…

Statistics Theory · Mathematics 2025-11-10 Xin Bing , Dehan Kong , Bingqing Li

In MRI, images of the same contrast (e.g., T$_1$) from the same subject can exhibit noticeable differences when acquired using different hardware, sequences, or scan parameters. These differences in images create a domain gap that needs to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Hwihun Jeong , Heejoon Byun , Dong Un Kang , Jongho Lee

In this technical note, we address an unresolved challenge in neuroimaging statistics: how to determine which of several datasets is the best for inferring neuronal responses. Comparisons of this kind are important for experimenters when…

The wealth of data being gathered about humans and their surroundings drives new machine learning applications in various fields. Consequently, more and more often, classifiers are trained using not only numerical data but also complex data…

Machine Learning · Computer Science 2022-04-13 Maciej Piernik , Dariusz Brzezinski , Pawel Zawadzki

The homography matrix is a key component in various vision-based robotic tasks. Traditionally, homography estimation algorithms are classified into feature- or intensity-based. The main advantages of the latter are their versatility,…

Computer Vision and Pattern Recognition · Computer Science 2022-03-09 Lucas Nogueira , Ely C. de Paiva , Geraldo Silvera

Real-world measurements often comprise a dominant signal contaminated by a noisy background. Robustly estimating the dominant signal in practice has been a fundamental statistical problem. Classically, mixture models have been used to…

Computation · Statistics 2026-05-20 Ananyabrata Barua , Ayanendranath Basu

In recent years there has been a burgeoning interest in the use of computational methods to distinguish between elicited speech samples produced by patients with dementia, and those from healthy controls. The difference between perplexity…

Computation and Language · Computer Science 2020-06-30 Trevor Cohen , Serguei Pakhomov

Achieving balanced alignment of large language models (LLMs) in terms of Helpfulness, Honesty, and Harmlessness (3H optimization) constitutes a cornerstone of responsible AI. Existing methods like data mixture strategies face limitations,…

Computation and Language · Computer Science 2026-02-03 Jinluan Yang , Dingnan Jin , Anke Tang , Li Shen , Didi Zhu , Zhengyu Chen , Ziyu Zhao , Daixin Wang , Qing Cui , Zhiqiang Zhang , Jun Zhou , Fei Wu , Kun Kuang

As machine learning applications grow increasingly ubiquitous and complex, they face an increasing set of requirements beyond accuracy. The prevalent approach to handle this challenge is to aggregate a weighted combination of requirement…

Machine Learning · Computer Science 2026-01-07 Aneesh Barthakur , Luiz F. O. Chamon

Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Krish Desai

A line of recent work has analyzed the behavior of the Expectation-Maximization (EM) algorithm in the well-specified setting, in which the population likelihood is locally strongly concave around its maximizing argument. Examples include…

Statistics Theory · Mathematics 2020-04-30 Raaz Dwivedi , Nhat Ho , Koulik Khamaru , Michael I. Jordan , Martin J. Wainwright , Bin Yu