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When aligning large language models (LLMs), their performance on various tasks (such as being helpful, harmless, and honest) depends heavily on the composition of their training data. However, selecting a data mixture that achieves strong…

Machine Learning · Computer Science 2025-06-03 Nicholas E. Corrado , Julian Katz-Samuels , Adithya Devraj , Hyokun Yun , Chao Zhang , Yi Xu , Yi Pan , Bing Yin , Trishul Chilimbi

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Independent and identically distributed (i.i.d.) data is essential to many data analysis and modeling techniques. In the medical domain, collecting data from multiple sites or institutions is a common strategy that guarantees sufficient…

Machine Learning · Computer Science 2024-08-08 Bao Hoang , Yijiang Pang , Siqi Liang , Liang Zhan , Paul Thompson , Jiayu Zhou

Harmonization methods such as ComBat and its variants are widely used to mitigate diffusion MRI (dMRI) site-specific biases. However, ComBat assumes that subject distributions exhibit a Gaussian profile. In practice, patients with…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Yoan David , Pierre-Marc Jodoin , Alzheimer's Disease Neuroimaging Initiative , The TRACK-TBI Investigators

Deep learning algorithms utilizing magnetic resonance (MR) images have demonstrated cutting-edge proficiency in autonomously segmenting multiple sclerosis (MS) lesions. Despite their achievements, these algorithms may struggle to extend…

Image and Video Processing · Electrical Eng. & Systems 2023-11-01 Jinwei Zhang , Lianrui Zuo , Blake E. Dewey , Samuel W. Remedios , Savannah P. Hays , Dzung L. Pham , Jerry L. Prince , Aaron Carass

We jointly model longitudinal values of a psychometric test and diagnosis of dementia. The model is based on a continuous-time latent process representing cognitive ability. The link between the latent process and the observations is…

Statistics Theory · Mathematics 2007-06-13 Julien Ganiayre , Daniel Commenges , Luc Letenneur

Reliability in Neural Networks (NNs) is crucial in safety-critical applications like healthcare, and uncertainty estimation is a widely researched method to highlight the confidence of NNs in deployment. In this work, we propose an…

Machine Learning · Computer Science 2020-11-20 Utkarsh Sarawgi , Wazeer Zulfikar , Rishab Khincha , Pattie Maes

The Expectation-Maximization (EM) algorithm is one of the most popular methods used to solve the problem of parametric distribution-based clustering in unsupervised learning. In this paper, we propose to analyze a generalized EM (GEM)…

Optimization and Control · Mathematics 2021-05-19 Sarthak Chatterjee , Orlando Romero , Sérgio Pequito

The EM-algorithm is a general procedure to get maximum likelihood estimates if part of the observations on the variables of a network are missing. In this paper a stochastic version of the algorithm is adapted to probabilistic neural…

Artificial Intelligence · Computer Science 2013-03-26 Gerhard Paass

We investigate the problem of jointly testing a pair of composite hypotheses and, depending on the test result, estimating a random parameter under distributional uncertainties. Specifically, it is assumed that the distribution of the data…

Signal Processing · Electrical Eng. & Systems 2026-04-27 Dominik Reinhard , Michael Fauß , Abdelhak M. Zoubir

Symmetry-aware methods for machine learning, such as data augmentation and equivariant architectures, encourage correct model behavior on all transformations (e.g. rotations or permutations) of the original dataset. These methods can…

Machine Learning · Computer Science 2026-03-31 Hannah Lawrence , Elyssa Hofgard , Vasco Portilheiro , Yuxuan Chen , Tess Smidt , Robin Walters

Brain encoding and decoding aims to understand the relationship between external stimuli and brain activities, and is a fundamental problem in neuroscience. In this article, we study latent embedding alignment for brain encoding and…

Methodology · Statistics 2026-03-24 Shuoxun Xu , Zhanhao Yan , Lexin Li

Data augmentation is an important technique in training deep neural networks as it enhances their ability to generalize and remain robust. While data augmentation is commonly used to expand the sample size and act as a consistency…

Machine Learning · Computer Science 2025-02-18 Xiliang Yang , Shenyang Deng , Shicong Liu , Yuanchi Suo , Wing. W. Y NG , Jianjun Zhang

We propose an adaptive learning procedure to learn patch-based image priors for image denoising. The new algorithm, called the Expectation-Maximization (EM) adaptation, takes a generic prior learned from a generic external database and…

Computer Vision and Pattern Recognition · Computer Science 2016-08-24 Enming Luo , Stanley H. Chan , Truong Q. Nguyen

Data-parallel (DP) training with synchronous all-reduce is a dominant paradigm for full-parameter fine-tuning of large language models (LLMs). While parameter synchronization guarantees numerical equivalence of model weights after each…

Machine Learning · Computer Science 2026-02-25 Hong Li , Zhen Zhou , Honggang Zhang , Yuping Luo , Xinyue Wang , Han Gong , Zhiyuan Liu

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Nearest neighbor (NN) matching as a tool to align data sampled from different groups is both conceptually natural and practically well-used. In a landmark paper, Abadie and Imbens (2006) provided the first large-sample analysis of NN…

Statistics Theory · Mathematics 2021-12-28 Zhexiao Lin , Peng Ding , Fang Han

In modern large-scale machine learning applications, the training data are often partitioned and stored on multiple machines. It is customary to employ the "data parallelism" approach, where the aggregated training loss is minimized without…

Machine Learning · Computer Science 2017-08-28 Shun Zheng , Jialei Wang , Fen Xia , Wei Xu , Tong Zhang

Mixture models postulate the overall population as a mixture of finite subpopulations with unobserved membership. Fitting mixture models usually requires large sample sizes and combining data from multiple sites can be beneficial. However,…

Methodology · Statistics 2025-12-19 Xiaokang Liu , Rui Duan , Raymond J. Carroll , Yang Ning , Yong Chen

A novel approach for unsupervised domain adaptation for neural networks is proposed. It relies on metric-based regularization of the learning process. The metric-based regularization aims at domain-invariant latent feature representations…

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