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The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view,…

Molecular Networks · Quantitative Biology 2023-04-05 Nicole Luchetti , Alessandro Loppini , Margherita Anna Grazia Matarrese , Letizia Chiodo , Simonetta Filippi

The integral control of positive systems using nonnegative control input is an important problem arising, among others, in biochemistry, epidemiology and ecology. An immediate solution is to use an ON-OFF nonlinearity between the controller…

Optimization and Control · Mathematics 2019-12-24 Corentin Briat

Living organisms exhibit remarkable adaptations across all scales, from molecules to ecosystems. We believe that many of these adaptations correspond to optimal solutions driven by evolution, training, and underlying physical and chemical…

Quantitative Methods · Quantitative Biology 2025-10-17 Julio R. Banga , Sebastian Sager

Robotic control systems are increasingly relying on distributed feedback controllers to tackle complex sensing and decision problems such as those found in highly articulated human-centered robots. These demands come at the cost of a…

Systems and Control · Computer Science 2015-01-14 Ye Zhao , Nicholas Paine , Kwan Suk Kim , Luis Sentis

Feedback alignment and related weight-transport-free algorithms are often proposed as biologically plausible alternatives to backpropagation, yet they are typically formulated in discrete phases with implicitly synchronized forward and…

Machine Learning · Computer Science 2026-03-03 Marc Gong Bacvanski , Liu Ziyin , Tomaso Poggio

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and many diverging properties. IDPs-and intrinsically disordered regions (IDRs) interspersed between folded domains-are generally characterized as…

Biomolecules · Quantitative Biology 2021-06-03 Kresten Lindorff-Larsen , Birthe B. Kragelund

In order to increase productivity, capability, and data exploitation, numerous defense applications are experiencing an integration of state-of-the-art machine learning and AI into their architectures. Especially for defense applications,…

Human-Computer Interaction · Computer Science 2020-03-24 Chris J. Michael , Dina Acklin , Jaelle Scheuerman

Widespread deployment of societal-scale machine learning systems necessitates a thorough understanding of the resulting long-term effects these systems have on their environment, including loss of trustworthiness, bias amplification, and…

Machine Learning · Computer Science 2024-05-07 Andrey Veprikov , Alexander Afanasiev , Anton Khritankov

Achieving advanced machine intelligence remains a central challenge in AI research, often approached through scaling neural architectures and generative models. However, biological systems offer a broader repertoire of strategies for…

Neurons and Cognition · Quantitative Biology 2026-05-26 Giovanni Pezzulo , Michael Levin

A common feature of biological networks is the geometric property of self-similarity. Molecular regulatory networks through to circulatory systems, nervous systems, social systems and ecological trophic networks, show self-similar…

Molecular Networks · Quantitative Biology 2012-03-09 Simon DeDeo , David C. Krakauer

Information-theoretic fundamental limitation in feedback control system is an important topic for decades. In this paper, a new bode-like fundamental inequality in causal feedback control system is developed. This inequality relates…

Information Theory · Computer Science 2015-08-18 Weimin Wang , Chong Xu

The machine learning development lifecycle is characterized by iterative and exploratory processes that rely on feedback mechanisms to ensure data and model integrity. Despite the critical role of feedback in machine learning engineering,…

Software Engineering · Computer Science 2024-08-02 Arumoy Shome , Luis Cruz , Diomidis Spinellis , Arie van Deursen

The purpose of this paper is to provide a brief review of some recent developments in quantum feedback networks and control. A quantum feedback network (QFN) is an interconnected system consisting of open quantum systems linked by free…

Quantum Physics · Physics 2013-07-25 Guofeng Zhang , Matthew R. James

Transformers have demonstrated impressive capabilities across various tasks, yet their performance on compositional problems remains a subject of debate. In this study, we investigate the internal mechanisms underlying Transformers'…

Computation and Language · Computer Science 2025-01-16 Zhongwang Zhang , Pengxiao Lin , Zhiwei Wang , Yaoyu Zhang , Zhi-Qin John Xu

Biological phenomena differ significantly from physical phenomena. At the heart of this distinction is the fact that biological entities have computational abilities and thus they are inherently difficult to predict. This is the reason why…

Molecular Networks · Quantitative Biology 2009-09-29 Pau Fernandez , Ricard V. Sole

Many biological systems dynamically rearrange their components through a sequence of configurations in order to perform their functions. Such dynamic processes have been studied using network models that sequentially retrieve a set of…

Statistical Mechanics · Physics 2022-12-01 Lukas Herron , Pablo Sartori , BingKan Xue

Biologically-informed neural networks typically leverage pathway annotations to enhance performance in biomedical applications. We hypothesized that the benefits of pathway integration does not arise from its biological relevance, but…

Quantitative Methods · Quantitative Biology 2025-05-08 Isabella Caranzano , Corrado Pancotti , Cesare Rollo , Flavio Sartori , Pietro Liò , Piero Fariselli , Tiziana Sanavia

The immune system is a highly parallel and distributed intelligent system which has learning, memory, and associative capabilities. Artificial Immune System is an evolutionary paradigm inspired by the biological aspects of the immune system…

Cryptography and Security · Computer Science 2011-02-22 Tejbanta Singh Chingtham , G. Sahoo , M. K. Ghose

We explore the hypothesis that the relative abundance of feedback loops in many empirical complex networks is severely reduced owing to the presence of an inherent global directionality. Aimed at quantifying this idea, we propose a simple…

Molecular Networks · Quantitative Biology 2015-02-16 Virginia Domínguez-García , Simone Pigolotti , Miguel A. Muñoz

Self adaptation has been proposed to overcome the complexity of today's software systems which results from the uncertainty issue. Aspects of uncertainty include changing systems goals, changing resource availability and dynamic operating…

Software Engineering · Computer Science 2015-08-07 Yousef Abuseta , Khaled Swesi