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Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Roarke Horstmeyer , Richard Y. Chen , Barbara Kappes , Benjamin Judkewitz

Standard microscopes offer a variety of settings to help improve the visibility of different specimens to the end microscope user. Increasingly, however, digital microscopes are used to capture images for automated interpretation by…

Image and Video Processing · Electrical Eng. & Systems 2020-10-14 Kanghyun Kim , Pavan Chandra Konda , Colin L. Cooke , Ron Appel , Roarke Horstmeyer

Predicting if red blood cells (RBC) are infected with the malaria parasite is an important problem in Pathology. Recently, supervised machine learning approaches have been used for this problem, and they have had reasonable success. In…

Computer Vision and Pattern Recognition · Computer Science 2020-10-05 Anik Khan , Kishor Datta Gupta , Deepak Venugopal , Nirman Kumar

Optical microscopy is an indispensable tool in life sciences research, but conventional techniques require compromises between imaging parameters like speed, resolution, field-of-view, and phototoxicity. To overcome these limitations,…

Quantitative Methods · Quantitative Biology 2024-04-01 Leonor Morgado , Estibaliz Gómez-de-Mariscal , Hannah S. Heil , Ricardo Henriques

Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 R. Morelli , L. Clissa , M. Dalla , M. Luppi , L. Rinaldi , A. Zoccoli

Accurately counting cells in microscopic images is important for medical diagnoses and biological studies, but manual cell counting is very tedious, time-consuming, and prone to subjective errors, and automatic counting can be less accurate…

Computer Vision and Pattern Recognition · Computer Science 2019-03-25 Shenghua He , Kyaw Thu Minn , Lilianna Solnica-Krezel , Mark Anastasio , Hua Li

We demonstrate that a deep neural network can significantly improve optical microscopy, enhancing its spatial resolution over a large field-of-view and depth-of-field. After its training, the only input to this network is an image acquired…

Machine Learning · Computer Science 2017-11-21 Yair Rivenson , Zoltan Gorocs , Harun Gunaydin , Yibo Zhang , Hongda Wang , Aydogan Ozcan

Automated in-vitro cell detection and counting have been a key theme for artificial and intelligent biological analysis such as biopsy, drug analysis and decease diagnosis. Along with the rapid development of microfluidics and lab-on-chip…

Computer Vision and Pattern Recognition · Computer Science 2020-01-08 Tiancheng Xia , Richard Jiang , YongQing Fu , Nanlin Jin

Computer-aided analysis of biological microscopy data has seen a massive improvement with the utilization of general-purpose deep learning techniques. Yet, in microscopy studies of multi-organism systems, the problem of collision and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-09 Albert Alonso , Julius B. Kirkegaard

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

The objective of the study is to evaluate the efficiency of a multi layer neural network models built by combining Recurrent Neural Network(RNN) and Convolutional Neural Network(CNN) for solving the problem of classifying different types of…

Computer Vision and Pattern Recognition · Computer Science 2021-01-12 Indraneel Ghosh , Siddhant Kundu

Deep learning based models have had great success in object detection, but the state of the art models have not yet been widely applied to biological image data. We apply for the first time an object detection model previously used on…

Microfluidic devices offer numerous advantages in medical applications, including the capture of single cells in microwell-based platforms for genomic analysis. As the cost of sequencing decreases, the demand for high-throughput single-cell…

Computational Engineering, Finance, and Science · Computer Science 2024-09-13 Xueying Zhao , Yan Chen , Yuefu Jiang , Amie Radenbaugh , Jamie Moskwa , Devon Jensen

Convolutional neural networks (CNN) have become a powerful tool for detecting patterns in image data. Recent papers report promising results in the domain of disease detection using brain MRI data. Despite the high accuracy obtained from…

Image and Video Processing · Electrical Eng. & Systems 2020-08-19 Arjun Haridas Pallath , Martin Dyrba

Malaria, a life-threatening disease, infects millions of people every year throughout the world demanding faster diagnosis for proper treatment before any damages occur. In this paper, an end-to-end deep learning-based approach is proposed…

Computer Vision and Pattern Recognition · Computer Science 2020-12-11 Tanvir Mahmud , Shaikh Anowarul Fattah

The analysis and counting of blood cells in a microscope image can provide useful information concerning to the health of a person. In particular, morphological analysis of red blood cells deformations can effectively detect important…

Computers and Society · Computer Science 2013-12-05 Pramit Ghosh , Debotosh Bhattacharjee , Mita Nasipuri , Dipak Kumar Basu

Malaria, a mosquito-borne disease caused by a parasite, kills over 1 million people globally each year. People, if left untreated, may develop severe complications, leading to death. Effective and accurate diagnosis is important for the…

Image and Video Processing · Electrical Eng. & Systems 2020-09-02 Alexander Tao , Boran Han

When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes denser and their images begin to coincide, existing solutions…

Optics · Physics 2013-09-02 Anthony Barsic , Ginni Grover , Rafael Piestun

Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput. Artificial intelligence, deep…

The integration of Artificial Intelligence (AI) in medical diagnostics is often hindered by model opacity, where high-accuracy systems function as "black boxes" without transparent reasoning. This limitation is critical in clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Pascal Passigan , Vayd Ramkumar
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