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We consider a general non-linear model where the signal is a finite mixture of an unknown, possibly increasing, number of features issued from a continuous dictionary parameterized by a real non-linear parameter. The signal is observed with…

Machine Learning · Statistics 2025-04-10 Cristina Butucea , Jean-François Delmas , Anne Dutfoy , Clément Hardy

Fluorescence microscopy is widely used for the study of biological specimens. Deconvolution can significantly improve the resolution and contrast of images produced using fluorescence microscopy; in particular, Bayesian-based methods have…

Methodology · Statistics 2015-02-04 Alexander Wong , Xiao Yu Wang , Maud Gorbet

In deep tissue photoacoustic imaging the spatial resolution is inherently limited by the acoustic wavelength. Recently, it was demonstrated that it is possible to surpass the acoustic diffraction limit by analyzing fluctuations in a set of…

The use of fluorescent molecules to create long sequences of low-density, diffraction-limited images enables highly-precise molecule localization. However, this methodology requires lengthy imaging times, which limits the ability to view…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Yair Ben Sahel , Yonina C. Eldar

Fluorescence microscopy is essential in biological and medical research, providing critical insights into cellular structures. However, limited by optical diffraction and background noise, a substantial amount of hidden information is still…

Biological Physics · Physics 2026-04-14 Xiaofeng Zhang , Yongsheng Huang , Jielong Yang , Zhili Wang , Si Chen , Linbo Liu , Xin Ge

Off-the-grid regularisation has been extensively employed over the last decade in the context of ill-posed inverse problems formulated in the continuous setting of the space of Radon measures $\mathcal{M}(\mathcal{X})$. These approaches…

Numerical Analysis · Mathematics 2025-04-15 Marta Lazzaretti , Claudio Estatico , Alejandro Melero , Luca Calatroni

The demands of proliferating big data and massive deep learning models, against a backdrop of a mounting climate emergency and the abating of Moore's law, push technologists to develop high-speed, high-throughput, low energy and…

Optics · Physics 2023-03-17 Benjamin Wetherfield , Timothy D. Wilkinson

This paper considers the problem of recovering an ensemble of Diracs on a sphere from its low resolution measurements. The Diracs can be located at any location on the sphere, not necessarily on a grid. We show that under a separation…

Information Theory · Computer Science 2015-06-23 Tamir Bendory , Shai Dekel , Arie Feuer

This work develops a nonlinear multigrid method for diffusion problems discretized by cell-centered finite volume methods on general unstructured grids. The multigrid hierarchy is constructed algebraically using aggregation of degrees of…

Numerical Analysis · Mathematics 2020-10-29 Chak Shing Lee , François Hamon , Nicola Castelletto , Panayot S. Vassilevski , Joshua White

For several centuries, far-field optical microscopy has remained a key instrument in many scientific disciplines including physical, chemical and biomedical research. Nonetheless, far-field imaging has many limitations: the spatial…

Optics · Physics 2020-01-27 Lyubov V. Amitonova , Johannes F. de Boer

Optical computing has reemerged as a promising alternative computing paradigm for providing energy-efficient information processing in the age of artificial intelligence. Among various photonic neural network platforms, diffractive optical…

Optics · Physics 2025-02-18 Bahadır Utku Kesgin , Firdevs Yüce , Uğur Teğin

A solution to the inversion problem of scattering would offer aberration-free diffraction-limited 3D images without the resolution and depth-of-field limitations of lens-based tomographic systems. Powerful algorithms are increasingly being…

While high-resolution microscopic techniques are crucial for studying cellular structures in cell biology, obtaining such images from thick 3D engineered tissues remains challenging. In this review, we explore advancements in fluorescence…

Tissues and Organs · Quantitative Biology 2025-02-07 Yasaman Kargar Gaz Kooh , Nathaniel Huebsch

Fourier light-field microscopy (FLFM) uses a micro-lens array (MLA) to segment the Fourier Plane of the microscopic objective lens to generate multiple two-dimensional perspective views, thereby reconstructing the three-dimensional(3D)…

Optics · Physics 2022-08-29 Haixin Huang , Haoyuan Qiu , Hanzhe Wu , Yihong Ji , Heng Li , Bin Yu , Danni Chen , Junle Qu

Even though image signals are typically defined on a regular two-dimensional grid, there also exist many scenarios where this is not the case and the amplitude of the image signal only is available for a non-regular subset of pixel…

Image and Video Processing · Electrical Eng. & Systems 2022-04-28 Jürgen Seiler , Markus Jonscher , Michael Schöberl , André Kaup

Recently, deep learning approaches have become the main research frontier for biological image reconstruction and enhancement problems thanks to their high performance, along with their ultra-fast inference times. However, due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Mehmet Akçakaya , Burhaneddin Yaman , Hyungjin Chung , Jong Chul Ye

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

Optics · Physics 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

A variety of recent imaging techniques are able to beat the diffraction limit in fluorescence microcopy by activating and localizing subsets of the fluorescent molecules in the specimen, and repeating this process until all of the molecules…

Optics · Physics 2010-08-27 Alexander R. Small

Recently, it was discovered that microsphere can generate super-resolution focusing beyond diffraction limit. This has led to the development of an exciting super-resolution imaging technique -microsphere nanoscopy- that features a record…

Optics · Physics 2021-08-26 Zengbo Wang

Image reconstruction under multiple light scattering is crucial in a number of applications such as diffraction tomography. The reconstruction problem is often formulated as a nonconvex optimization, where a nonlinear measurement model is…

Computer Vision and Pattern Recognition · Computer Science 2018-07-04 Yu Sun , Zhihao Xia , Ulugbek S. Kamilov