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A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods have been developed to use statistical correlations in…

Quantitative Methods · Quantitative Biology 2010-11-24 Adam A. Margolin , Kai Wang , Andrea Califano , Ilya Nemenman

Randomized algorithms, such as randomized sketching or stochastic optimization, are a promising approach to ease the computational burden in analyzing large datasets. However, randomized algorithms also produce non-deterministic outputs,…

Methodology · Statistics 2025-05-13 Zhixiang Zhang , Sokbae Lee , Edgar Dobriban

Graphical causal models led to the development of complete non-parametric identification theory in arbitrary structured systems, and general approaches to efficient inference. Nevertheless, graphical approaches to causal inference have not…

Methodology · Statistics 2021-11-02 AmirEmad Ghassami , Ilya Shpitser

The inference of gene regulatory networks from high throughput gene expression data is one of the major challenges in systems biology. This paper aims at analysing and comparing two different algorithmic approaches. The first approach uses…

Quantitative Methods · Quantitative Biology 2008-12-05 A. Braunstein , A. Pagnani , M. Weigt , R. Zecchina

Directed acyclic graphs (DAGs) are commonly used to represent causal relationships among random variables in graphical models. Applications of these models arise in the study of physical, as well as biological systems, where directed edges…

Machine Learning · Statistics 2009-12-01 Ali Shojaie , George Michailidis

Structural causal models postulate noisy functional relations among a set of interacting variables. The causal structure underlying each such model is naturally represented by a directed graph whose edges indicate for each variable which…

Statistics Theory · Mathematics 2022-03-15 David Strieder , Tobias Freidling , Stefan Haffner , Mathias Drton

Linear regression on network-linked observations has been an essential tool in modeling the relationship between response and covariates with additional network structures. Previous methods either lack inference tools or rely on restrictive…

Methodology · Statistics 2022-08-22 Can M. Le , Tianxi Li

Interference exists when a unit's outcome depends on another unit's treatment assignment. For example, intensive policing on one street could have a spillover effect on neighboring streets. Classical randomization tests typically break down…

Methodology · Statistics 2021-05-26 David Puelz , Guillaume Basse , Avi Feller , Panos Toulis

Undirected graphical models are applied in genomics, protein structure prediction, and neuroscience to identify sparse interactions that underlie discrete data. Although Bayesian methods for inference would be favorable in these contexts,…

Machine Learning · Statistics 2017-06-15 John Ingraham , Debora Marks

In this work, we formalize the problem of causal inference over graph-based relational time-series data where each node in the graph has one or more time-series associated to it. We propose causal inference models for this problem that…

Machine Learning · Computer Science 2020-01-27 Ryan Rossi , Somdeb Sarkhel , Nesreen Ahmed

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing…

Methodology · Statistics 2021-11-30 Tassilo Schwarz

We address the problem of inferring an undirected graph from nodal observations, which are modeled as non-stationary graph signals generated by local diffusion dynamics that depend on the structure of the unknown network. Using the…

Signal Processing · Electrical Eng. & Systems 2019-02-01 Rasoul Shafipour , Santiago Segarra , Antonio G. Marques , Gonzalo Mateos

Reconstructing transcriptional regulatory networks is an important task in functional genomics. Data obtained from experiments that perturb genes by knockouts or RNA interference contain useful information for addressing this reconstruction…

Machine Learning · Statistics 2015-06-18 Ali Shojaie , Alexandra Jauhiainen , Michael Kallitsis , George Michailidis

We study the problem of non-Bayesian social learning with uncertain models, in which a network of agents seek to cooperatively identify the state of the world based on a sequence of observed signals. In contrast with the existing…

Optimization and Control · Mathematics 2019-09-11 César A. Uribe , James Z. Hare , Lance Kaplan , Ali Jadbabaie

Uncertain, or probabilistic, graphs have been increasingly used to represent noisy linked data in many emerging applications, and have recently attracted the attention of the database research community. A fundamental problem on uncertain…

Social and Information Networks · Computer Science 2019-04-11 Xiangyu Ke , Arijit Khan , Leroy Lim Hong Quan

We consider the problem of learning causal directed acyclic graphs from an observational joint distribution. One can use these graphs to predict the outcome of interventional experiments, from which data are often not available. We show…

Machine Learning · Statistics 2016-08-18 Jonas Peters , Joris Mooij , Dominik Janzing , Bernhard Schölkopf

We consider the problem of inferring the directed, causal graph from observational data, assuming no hidden confounders. We take an information theoretic approach, and make three main contributions. First, we show how through algorithmic…

Machine Learning · Statistics 2018-09-07 Alexander Marx , Jilles Vreeken

Network structures underlie the dynamics of many complex phenomena, from gene regulation and foodwebs to power grids and social media. Yet, as they often cannot be observed directly, their connectivities must be inferred from observations…

Machine Learning · Computer Science 2023-11-02 Thomas Gaskin , Grigorios A. Pavliotis , Mark Girolami

Detecting the interactions of genetic compounds like genes, SNPs, proteins, metabolites, etc. can potentially unravel the mechanisms behind complex traits and common genetic disorders. Several methods have been taken into consideration for…

Computational Engineering, Finance, and Science · Computer Science 2015-05-26 Francesco Gadaleta

Segmented regression is a standard statistical procedure used to estimate the effect of a policy intervention on time series outcomes. This statistical method assumes the normality of the outcome variable, a large sample size, no…

Applications · Statistics 2020-02-18 Mohammad M. Islam , Ph. D. , Erik L. Heiny , Ph. D
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