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Biological networks provide insight into the complex organization of biological processes in a cell at the system level. They are an effective tool for understanding the comprehensive map of functional interactions, finding the functional…

Molecular Networks · Quantitative Biology 2017-09-14 Somaye Hashemifar

Accurate localization of proteins from fluorescence microscopy images is challenging due to the inter-class similarities and intra-class disparities introducing grave concerns in addressing multi-class classification problems. Conventional…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Muhammad Tahir , Saeed Anwar , Ajmal Mian , Abdul Wahab Muzaffar

Accurate and robust correspondence matching is of utmost importance for various 3D computer vision tasks. However, traditional explicit programming-based methods often struggle to handle challenging scenarios, and deep learning-based…

Computer Vision and Pattern Recognition · Computer Science 2023-09-01 Chenbo Zhou , Shuai Su , Qijun Chen , Rui Fan

The interactions between cells and the extracellular matrix are vital for the self-organisation of tissues. In this paper we present proof-of-concept to use machine learning tools to predict the role of this mechanobiology in the…

Tissues and Organs · Quantitative Biology 2023-04-03 Allison E. Andrews , Hugh Dickinson , James P. Hague

Computational prediction of membrane protein (MP) structures is very challenging partially due to lack of sufficient solved structures for homology modeling. Recently direct evolutionary coupling analysis (DCA) sheds some light on protein…

Biomolecules · Quantitative Biology 2017-05-11 Zhen Li , Sheng Wang , Yizhou Yu , Jinbo Xu

Extracellular matrix (ECM) remodeling is central to a wide variety of healthy and diseased tissue processes. Unfortunately, predicting ECM remodeling under various chemical and mechanical conditions has proven to be excessively challenging,…

Molecular Networks · Quantitative Biology 2026-05-26 Hasi Hays , William J. Richardson

Photonic neural networks offer a promising alternative to traditional electronic systems for machine learning accelerators due to their low latency and energy efficiency. However, the challenge of implementing the backpropagation algorithm…

Computational elucidation of membrane protein (MP) structures is challenging partially due to lack of sufficient solved structures for homology modeling. Here we describe a high-throughput deep transfer learning method that first predicts…

Biomolecules · Quantitative Biology 2017-08-29 Sheng Wang , Zhen Li , Yizhou Yu , Jinbo Xu

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Biomolecules · Quantitative Biology 2024-02-09 Song Yin , Xuenan Mi , Diwakar Shukla

Deep learning is popular as an end-to-end framework extracting the prominent features and performing the classification also. In this paper, we extensively investigate deep networks as an alternate to feature encoding technique of low level…

Machine Learning · Computer Science 2018-11-15 Bhalaji Nagarajan , V Ramana Murthy Oruganti

Deep neural networks are widely used for classification. These deep models often suffer from a lack of interpretability -- they are particularly difficult to understand because of their non-linear nature. As a result, neural networks are…

Artificial Intelligence · Computer Science 2017-11-22 Oscar Li , Hao Liu , Chaofan Chen , Cynthia Rudin

We develop a probabilistic framework for deep learning based on the Deep Rendering Mixture Model (DRMM), a new generative probabilistic model that explicitly capture variations in data due to latent task nuisance variables. We demonstrate…

Machine Learning · Statistics 2016-12-07 Ankit B. Patel , Tan Nguyen , Richard G. Baraniuk

The prediction of express delivery sequence, i.e., modeling and estimating the volumes of daily incoming and outgoing parcels for delivery, is critical for online business, logistics, and positive customer experience, and specifically for…

Machine Learning · Computer Science 2021-08-19 Siyuan Ren , Bin Guo , Longbing Cao , Ke Li , Jiaqi Liu , Zhiwen Yu

Predicting protein properties such as solvent accessibility and secondary structure from its primary amino acid sequence is an important task in bioinformatics. Recently, a few deep learning models have surpassed the traditional window…

Machine Learning · Computer Science 2016-05-11 Zeming Lin , Jack Lanchantin , Yanjun Qi

Recently exciting progress has been made on protein contact prediction, but the predicted contacts for proteins without many sequence homologs is still of low quality and not very useful for de novo structure prediction. This paper presents…

Biomolecules · Quantitative Biology 2017-01-10 Sheng Wang , Siqi Sun , Zhen Li , Renyu Zhang , Jinbo Xu

We introduce DeepCell, a novel circuit representation learning framework that effectively integrates multiview information from both And-Inverter Graphs (AIGs) and Post-Mapping (PM) netlists. At its core, DeepCell employs a self-supervised…

Machine Learning · Computer Science 2025-07-09 Zhengyuan Shi , Chengyu Ma , Ziyang Zheng , Lingfeng Zhou , Hongyang Pan , Wentao Jiang , Fan Yang , Xiaoyan Yang , Zhufei Chu , Qiang Xu

Motivation Protein fold recognition is an important problem in structural bioinformatics. Almost all traditional fold recognition methods use sequence (homology) comparison to indirectly predict the fold of a tar get protein based on the…

Machine Learning · Computer Science 2017-06-06 Jie Hou , Badri Adhikari , Jianlin Cheng

Many modern applications involve predicting structured, non-Euclidean outputs such as probability distributions, networks, and symmetric positive-definite matrices. These outputs are naturally modeled as elements of general metric spaces,…

Machine Learning · Statistics 2025-09-30 Yidong Zhou , Su I Iao , Hans-Georg Müller

Extracting scientific results from high-energy collider data involves the comparison of data collected from the experiments with synthetic data produced from computationally-intensive simulations. Comparisons of experimental data and…

High Energy Physics - Experiment · Physics 2022-11-23 Matthew Feickert , Mihir Katare , Mark Neubauer , Avik Roy

A critical factor in adopting machine learning for time-sensitive financial tasks is computational speed, including model training and inference. This paper demonstrates that a broad class of such problems, especially those previously…

Computational Finance · Quantitative Finance 2025-05-27 Liexin Cheng , Xue Cheng , Shuaiqiang Liu
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