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Tissue Engineering (TE) is an interdisciplinary field dealing with the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ.…

Tissues and Organs · Quantitative Biology 2015-01-22 S. Sircar , J. N. Majumdar

Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…

Tissues and Organs · Quantitative Biology 2015-04-06 Richard J. McMurtrey

Tissue engineering technology and tissue cell-based stem cell research have made great strides in treating tissue and organ damage, correcting tissue and organ dysfunction, and reducing surgical complications. In the past, traditional…

Tissues and Organs · Quantitative Biology 2021-11-19 Elcin Huseyn

A new strategy with bone tissue engineering by mesenchymal stem cell transplantation on titanium implant has been dawn attention. The surface scaffold properties of titanium surface play an important role in bone regenerative potential of…

Cell Behavior · Quantitative Biology 2010-05-03 Yukimichi Tamaki , Yu Kataoka , Takashi Miyazaki

In the middle of the last century, it has been known that neural stem cells (NSCs) play a key role in regenerative medicine to cure the neurodegenerative disease. This review article covers about the introduction to neural stem cell biology…

Neurons and Cognition · Quantitative Biology 2018-04-06 Divyanjali Shanmuganathan , Nivethika Sivakumaran

Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in…

Applications · Statistics 2025-08-29 Haim Bar , Huyen Nguyen , Joanne Conover

Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs…

Tissues and Organs · Quantitative Biology 2017-07-10 Aylin Acun , Dervis Can Vural , Pinar Zorlutuna

In tissue engineering, we seek to address comprehensive tissue repair and regeneration needs. Aligned nanofibers have emerged as powerful and versatile tools, attributable to their structural and biochemical congruence with the natural…

Medical Physics · Physics 2024-08-16 Gayatri Patel , Louis-S. Bouchard

Medical imaging is an invaluable resource in medicine as it enables to peer inside the human body and provides scientists and physicians with a wealth of information indispensable for understanding, modelling, diagnosis, and treatment of…

Image and Video Processing · Electrical Eng. & Systems 2022-08-25 Hanene Ben Yedder , Ben Cardoen , Ghassan Hamarneh

Tissue fibrosis is the phenomenon that a tissue has progressive deposition of collagen fibers with age. Tissue fibrosis is associated with aging of most of our organs, and it is the main pathology in arteriosclerosis, chronic…

Tissues and Organs · Quantitative Biology 2017-09-07 Jicun Wang-Michelitsch , Thomas M. Michelitsch

Gradual transformation of the epidermal stem cells to corneocytes involves a chain of chronologically well-arranged events that mostly stimulated locally by their neighbors. Cell diversity that observed during the differentiation through…

Tissues and Organs · Quantitative Biology 2008-04-22 A. Mezentsev

People use various products containing chemical substances that can diffuse through the human skin barrier and reach deeper layers. Therefore, it is essential to understand the transport mechanisms of these chemicals. We developed…

Numerical Analysis · Mathematics 2025-08-12 Milana Tesfamarian , Arne Nägel , Michael Heisig , Gabriel Wittum

After injury, if regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after…

Tissues and Organs · Quantitative Biology 2019-03-05 Diane Peurichard , Marielle Ousset , Jenny Paupert , Benjamin Aymard , Anne Lorsignol , Louis Casteilla , Pierre Degond

We study a cross-diffusion model for tissue regeneration which involves the dynamics of human mesenchymal stem cells interacting with chondrocytes in a medium containing a differentiation factor. The latter acts as a chemoattractant for the…

Analysis of PDEs · Mathematics 2025-11-04 Nishith Mohan , Christina Surulescu

The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth,…

Biological Physics · Physics 2024-04-10 Johannes C. Krämer , Edouard Hannezo , Gerhard Gompper , Jens Elgeti

Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tissue), causes discomfort and inflammation, and is related to…

Tissues and Organs · Quantitative Biology 2022-09-13 Claire Miller , Edmund Crampin , James Osborne

There is an unmet need for artificial intelligence techniques that can speed up the design of growth strategies for cultured tissues. Cultured tissue is increasingly important for a range of applications such as cultivated meat,…

Biological Physics · Physics 2025-08-04 Allison E. Andrews , Hugh Dickinson , James P. Hague

Through mechanical forces, biological cells remodel the surrounding collagen network, generating striking deformation patterns. Tethers-tracts of high densification and fiber alignment-form between cells, thinner bands emanate from cell…

Biomaterial systems have allowed for the in vitro production of complex, emergent tissue behaviors that were not possible with conventional 2D culture systems allowing for analysis of the normal development as well as disease processes. We…

Tissues and Organs · Quantitative Biology 2019-10-16 Matthew S Hall , Joseph T Decker , Lonnie D Shea

Biomaterials are becoming an essential tool in the study and application of stem cell research. Various types of biomaterials enable three-dimensional (3D) culture of stem cells, and, more recently, also enable high-resolution patterning…

Tissues and Organs · Quantitative Biology 2016-10-11 Richard J. McMurtrey
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